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Dietary carotenoids and risk of colon cancer: case-control study.

Abstract

Some epidemiological studies suggest that consumption of fruits and vegetables with a high carotenoid content may protect against colon cancer (CC). The evidence, however, is not completely consistent. Given the inconsistencies in findings in previous studies and continued interest in identifying modifiable risk factors for CC, a case-control study of French-Canadian in Montreal, Canada, was undertaken to examine the possible association between dietary carotenoids and CC risk and to investigate whether this association varies in relation to lifestyle factors such as smoking or diet, and particularly the high consumption of long-chain polyunsaturated fatty acids (LCPUFA). A total of 402 colorectal cases (200 males and 202 females) and 688 population-based controls matched for age, gender and place of residence were interviewed. Dietary intake was assessed through a validated food frequency questionnaire that collected information on over 200 food items and recipes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in unconditional logistic regression models. After adjustment for important variables such as total energy intake, no association was found between dietary intake of carotenoids and CC risk. For women with high intakes of LCPUFA, an inverse association was found between lutein + zeaxanthin and CC risk. ORs were 0.41; 95%CI (0.19-0.91), p=0.03 for eicosapentaenoic acid, and OR=0.36, 95%CI (0.19-0.78), p=0.01 for docosahexaenoic acid, when the upper quartiles of intake were compared to the lower. Among never-smokers, a significantly reduced risk of CC was associated with intake of beta-carotene [OR=0.44, 95%CI (0.21-0.92) and p=0.02], whereas an inverse association was found between lycopene intake and CC risk [OR=0.63, 95%CI (0.40-0.98) and p=0.05] among smokers. The results of our study suggest that a diet rich in both lutein + zeaxanthin and LCPUFAs may help prevent CC in French-Canadian females.

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  • Authors+Show Affiliations

    ,

    Epidemiology Research Unit, Research Centre, CHUM-Hôtel-Dieu, Pavillon Masson, 3850 St. Urbain, Montreal, Quebec, Canada H2W 1T7.

    Source

    International journal of cancer 110:1 2004 May 20 pg 110-6

    MeSH

    Adult
    Aged
    Carotenoids
    Case-Control Studies
    Colonic Neoplasms
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids, Unsaturated
    Female
    Humans
    Lutein
    Male
    Middle Aged
    Xanthophylls
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15054875

    Citation

    Nkondjock, André, and Parviz Ghadirian. "Dietary Carotenoids and Risk of Colon Cancer: Case-control Study." International Journal of Cancer, vol. 110, no. 1, 2004, pp. 110-6.
    Nkondjock A, Ghadirian P. Dietary carotenoids and risk of colon cancer: case-control study. Int J Cancer. 2004;110(1):110-6.
    Nkondjock, A., & Ghadirian, P. (2004). Dietary carotenoids and risk of colon cancer: case-control study. International Journal of Cancer, 110(1), pp. 110-6.
    Nkondjock A, Ghadirian P. Dietary Carotenoids and Risk of Colon Cancer: Case-control Study. Int J Cancer. 2004 May 20;110(1):110-6. PubMed PMID: 15054875.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary carotenoids and risk of colon cancer: case-control study. AU - Nkondjock,André, AU - Ghadirian,Parviz, PY - 2004/4/1/pubmed PY - 2004/5/7/medline PY - 2004/4/1/entrez SP - 110 EP - 6 JF - International journal of cancer JO - Int. J. Cancer VL - 110 IS - 1 N2 - Some epidemiological studies suggest that consumption of fruits and vegetables with a high carotenoid content may protect against colon cancer (CC). The evidence, however, is not completely consistent. Given the inconsistencies in findings in previous studies and continued interest in identifying modifiable risk factors for CC, a case-control study of French-Canadian in Montreal, Canada, was undertaken to examine the possible association between dietary carotenoids and CC risk and to investigate whether this association varies in relation to lifestyle factors such as smoking or diet, and particularly the high consumption of long-chain polyunsaturated fatty acids (LCPUFA). A total of 402 colorectal cases (200 males and 202 females) and 688 population-based controls matched for age, gender and place of residence were interviewed. Dietary intake was assessed through a validated food frequency questionnaire that collected information on over 200 food items and recipes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in unconditional logistic regression models. After adjustment for important variables such as total energy intake, no association was found between dietary intake of carotenoids and CC risk. For women with high intakes of LCPUFA, an inverse association was found between lutein + zeaxanthin and CC risk. ORs were 0.41; 95%CI (0.19-0.91), p=0.03 for eicosapentaenoic acid, and OR=0.36, 95%CI (0.19-0.78), p=0.01 for docosahexaenoic acid, when the upper quartiles of intake were compared to the lower. Among never-smokers, a significantly reduced risk of CC was associated with intake of beta-carotene [OR=0.44, 95%CI (0.21-0.92) and p=0.02], whereas an inverse association was found between lycopene intake and CC risk [OR=0.63, 95%CI (0.40-0.98) and p=0.05] among smokers. The results of our study suggest that a diet rich in both lutein + zeaxanthin and LCPUFAs may help prevent CC in French-Canadian females. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15054875/full_citation L2 - https://doi.org/10.1002/ijc.20066 DB - PRIME DP - Unbound Medicine ER -