Type your tag names separated by a space and hit enter

Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study.

Abstract

OBJECTIVE

To assess the association between fasting insulin levels and breast cancer.

DESIGN

Cross sectional study.

PARTICIPANTS

3868 women aged 60-79 years.

MAIN OUTCOME MEASURE

Prevalent breast cancer (151 cases).

RESULTS

Insulin levels were positively associated with breast cancer. The age adjusted odds ratio (95% confidence interval) for a one unit increase in log(e) insulin levels among women without diabetes was 1.34 (1.02, 1.77). This association was not substantively altered by adjustment for potential confounding factors (age of menopause, hysterectomy/oophorectomy, hormone replacement use, oral contraceptive use, parity, adult social class and smoking) or potential mediating factors (body mass index, waist to hip ratio, leg length, age at menarche and childhood social class). Women with both long legs and higher insulin levels were at particularly increased risk, with breast cancer prevalence being 5.7% among women in the highest thirds of both insulin levels and leg-length compared to 1.8% among those in the lowest thirds of both. Positive associations between insulin levels and breast cancer were found for both pre- and post-menopausal breast cancers. Fasting glucose levels, HOMA score, diabetes and a history of gestational glycosuria or diabetes were also positively associated with breast cancer

CONCLUSIONS

Hyperinsulinaemia is positively associated with breast cancer in this cohort of older women. This effect may be mediated via a number of hormonal pathways acting at different stages of the life course.

Links

  • Aggregator Full Text
  • Authors+Show Affiliations

    ,

    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK. d.a.lawlor@bristol.ac.uk

    ,

    Source

    Cancer causes & control : CCC 15:3 2004 Apr pg 267-75

    MeSH

    Aged
    Breast Neoplasms
    Cross-Sectional Studies
    Female
    Humans
    Hyperinsulinism
    Male
    Menopause
    Middle Aged
    Odds Ratio
    Prevalence
    Risk Assessment
    United Kingdom

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15090721

    Citation

    Lawlor, Debbie A., et al. "Hyperinsulinaemia and Increased Risk of Breast Cancer: Findings From the British Women's Heart and Health Study." Cancer Causes & Control : CCC, vol. 15, no. 3, 2004, pp. 267-75.
    Lawlor DA, Smith GD, Ebrahim S. Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study. Cancer Causes Control. 2004;15(3):267-75.
    Lawlor, D. A., Smith, G. D., & Ebrahim, S. (2004). Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study. Cancer Causes & Control : CCC, 15(3), pp. 267-75.
    Lawlor DA, Smith GD, Ebrahim S. Hyperinsulinaemia and Increased Risk of Breast Cancer: Findings From the British Women's Heart and Health Study. Cancer Causes Control. 2004;15(3):267-75. PubMed PMID: 15090721.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study. AU - Lawlor,Debbie A, AU - Smith,George Davey, AU - Ebrahim,Shah, PY - 2004/4/20/pubmed PY - 2004/8/4/medline PY - 2004/4/20/entrez SP - 267 EP - 75 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 15 IS - 3 N2 - OBJECTIVE: To assess the association between fasting insulin levels and breast cancer. DESIGN: Cross sectional study. PARTICIPANTS: 3868 women aged 60-79 years. MAIN OUTCOME MEASURE: Prevalent breast cancer (151 cases). RESULTS: Insulin levels were positively associated with breast cancer. The age adjusted odds ratio (95% confidence interval) for a one unit increase in log(e) insulin levels among women without diabetes was 1.34 (1.02, 1.77). This association was not substantively altered by adjustment for potential confounding factors (age of menopause, hysterectomy/oophorectomy, hormone replacement use, oral contraceptive use, parity, adult social class and smoking) or potential mediating factors (body mass index, waist to hip ratio, leg length, age at menarche and childhood social class). Women with both long legs and higher insulin levels were at particularly increased risk, with breast cancer prevalence being 5.7% among women in the highest thirds of both insulin levels and leg-length compared to 1.8% among those in the lowest thirds of both. Positive associations between insulin levels and breast cancer were found for both pre- and post-menopausal breast cancers. Fasting glucose levels, HOMA score, diabetes and a history of gestational glycosuria or diabetes were also positively associated with breast cancer CONCLUSIONS: Hyperinsulinaemia is positively associated with breast cancer in this cohort of older women. This effect may be mediated via a number of hormonal pathways acting at different stages of the life course. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/15090721/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15090721.ui DB - PRIME DP - Unbound Medicine ER -