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The beneficial and detrimental effects of linoleic acid on autoimmune disorders.

Abstract

Type 1, or cellular, immune response is characterized by overproduction of IL-1, IL-2, IFN-gamma and TNF-alpha and is the underlying immune mechanism of some autoimmune disorders such as psoriasis, alopecia areata, rheumatoid arthritis, Crohn's disease, multiple sclerosis, insulin-dependent diabetes mellitus and experimental autoimmune uveitis. Type 2 immune response is seen in allergic and antibody-mediated autoimmune diseases and is characterized by IL-4, IL-6 and IL-10 overproduction. Linoleic acid is a precursor of prostaglandin E2 (PGE2) and its intake results in tissue production of PGE2, especially in the absence of other polyunsaturated fatty acids (PUFAS) which inhibit this conversion. PGE2 decreases the production of IL-1, IL-2, IFN-gamma and TNF-alpha and proliferation of TH1 cells and increases the production of IL-4, leading to suppression of the type 1 immune response. Taken together, linoleic acid, the major PUFA of maize oil, could have therapeutic efficacy against cellular autoimmune disorders. On the other hand, excessive intake of linoleic acid may aggravate type 2 autoimmune disorders.

Authors+Show Affiliations

Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran. namazi_mr@yahoo.com

Source

Autoimmunity 37:1 2004 Feb pg 73-5

MeSH

Autoimmune Diseases
Dinoprostone
Humans
Immune System
Linoleic Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15115315

Citation

Namazi, M R.. "The Beneficial and Detrimental Effects of Linoleic Acid On Autoimmune Disorders." Autoimmunity, vol. 37, no. 1, 2004, pp. 73-5.
Namazi MR. The beneficial and detrimental effects of linoleic acid on autoimmune disorders. Autoimmunity. 2004;37(1):73-5.
Namazi, M. R. (2004). The beneficial and detrimental effects of linoleic acid on autoimmune disorders. Autoimmunity, 37(1), pp. 73-5.
Namazi MR. The Beneficial and Detrimental Effects of Linoleic Acid On Autoimmune Disorders. Autoimmunity. 2004;37(1):73-5. PubMed PMID: 15115315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The beneficial and detrimental effects of linoleic acid on autoimmune disorders. A1 - Namazi,M R, PY - 2004/4/30/pubmed PY - 2004/9/15/medline PY - 2004/4/30/entrez SP - 73 EP - 5 JF - Autoimmunity JO - Autoimmunity VL - 37 IS - 1 N2 - Type 1, or cellular, immune response is characterized by overproduction of IL-1, IL-2, IFN-gamma and TNF-alpha and is the underlying immune mechanism of some autoimmune disorders such as psoriasis, alopecia areata, rheumatoid arthritis, Crohn's disease, multiple sclerosis, insulin-dependent diabetes mellitus and experimental autoimmune uveitis. Type 2 immune response is seen in allergic and antibody-mediated autoimmune diseases and is characterized by IL-4, IL-6 and IL-10 overproduction. Linoleic acid is a precursor of prostaglandin E2 (PGE2) and its intake results in tissue production of PGE2, especially in the absence of other polyunsaturated fatty acids (PUFAS) which inhibit this conversion. PGE2 decreases the production of IL-1, IL-2, IFN-gamma and TNF-alpha and proliferation of TH1 cells and increases the production of IL-4, leading to suppression of the type 1 immune response. Taken together, linoleic acid, the major PUFA of maize oil, could have therapeutic efficacy against cellular autoimmune disorders. On the other hand, excessive intake of linoleic acid may aggravate type 2 autoimmune disorders. SN - 0891-6934 UR - https://www.unboundmedicine.com/medline/citation/15115315/full_citation L2 - https://medlineplus.gov/autoimmunediseases.html DB - PRIME DP - Unbound Medicine ER -