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An active and socially integrated lifestyle in late life might protect against dementia.

Abstract

The recent availability of longitudinal data on the possible association of different lifestyles with dementia and Alzheimer's disease (AD) allow some preliminary conclusions on this topic. This review systematically analyses the published longitudinal studies exploring the effect of social network, physical leisure, and non-physical activity on cognition and dementia and then summarises the current evidence taking into account the limitations of the studies and the biological plausibility. For all three lifestyle components (social, mental, and physical), a beneficial effect on cognition and a protective effect against dementia are suggested. The three components seem to have common pathways, rather than specific mechanisms, which might converge within three major aetiological hypotheses for dementia and AD: the cognitive reserve hypothesis, the vascular hypothesis, and the stress hypothesis. Taking into account the accumulated evidence and the biological plausibility of these hypotheses, we conclude that an active and socially integrated lifestyle in late life protects against dementia and AD. Further research is necessary to better define the mechanisms of these associations and better delineate preventive and therapeutic strategies.

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  • Publisher Full Text
  • Authors

    , ,

    Source

    Lancet neurology 3:6 2004 Jun pg 343-53

    MeSH

    Aged
    Alzheimer Disease
    Clinical Trials as Topic
    Dementia
    Humans
    Leisure Activities
    Life Style
    Physical Fitness
    Risk Reduction Behavior
    Social Support
    Stress, Psychological

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    15157849

    Citation

    TY - JOUR T1 - An active and socially integrated lifestyle in late life might protect against dementia. AU - Fratiglioni,Laura, AU - Paillard-Borg,Stephanie, AU - Winblad,Bengt, PY - 2004/5/26/pubmed PY - 2004/7/9/medline PY - 2004/5/26/entrez SP - 343 EP - 53 JF - Lancet neurology JO - Lancet Neurol VL - 3 IS - 6 N2 - The recent availability of longitudinal data on the possible association of different lifestyles with dementia and Alzheimer's disease (AD) allow some preliminary conclusions on this topic. This review systematically analyses the published longitudinal studies exploring the effect of social network, physical leisure, and non-physical activity on cognition and dementia and then summarises the current evidence taking into account the limitations of the studies and the biological plausibility. For all three lifestyle components (social, mental, and physical), a beneficial effect on cognition and a protective effect against dementia are suggested. The three components seem to have common pathways, rather than specific mechanisms, which might converge within three major aetiological hypotheses for dementia and AD: the cognitive reserve hypothesis, the vascular hypothesis, and the stress hypothesis. Taking into account the accumulated evidence and the biological plausibility of these hypotheses, we conclude that an active and socially integrated lifestyle in late life protects against dementia and AD. Further research is necessary to better define the mechanisms of these associations and better delineate preventive and therapeutic strategies. SN - 1474-4422 UR - https://www.unboundmedicine.com/medline/citation/15157849/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S1474442204007677 ER -