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Primary open-angle glaucoma.
Lancet 2004; 363(9422):1711-20Lct

Abstract

Primary open-angle glaucoma is a progressive optic neuropathy and, perhaps, the most common form of glaucoma. Because the disease is treatable, and because the visual impairment caused by glaucoma is irreversible, early detection is essential. Early diagnosis depends on examination of the optic disc, retinal nerve fibre layer, and visual field. New imaging and psychophysical tests can improve both detection and monitoring of the progression of the disease. Recently completed long-term clinical trials provide convincing evidence that lowering intraocular pressure prevents progression at both the early and late stages of the disease. The degree of protection is related to the degree to which intraocular pressure is lowered. Improvements in therapy consist of more effective and better-tolerated drugs to lower intraocular pressure, and more effective surgical procedures. New treatments to directly treat and protect the retinal ganglion cells that are damaged in glaucoma are also in development.

Authors+Show Affiliations

Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946, USA. weinreb@eyecenter.ucsd.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15158634

Citation

Weinreb, Robert N., and Peng Tee Khaw. "Primary Open-angle Glaucoma." Lancet (London, England), vol. 363, no. 9422, 2004, pp. 1711-20.
Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004;363(9422):1711-20.
Weinreb, R. N., & Khaw, P. T. (2004). Primary open-angle glaucoma. Lancet (London, England), 363(9422), pp. 1711-20.
Weinreb RN, Khaw PT. Primary Open-angle Glaucoma. Lancet. 2004 May 22;363(9422):1711-20. PubMed PMID: 15158634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary open-angle glaucoma. AU - Weinreb,Robert N, AU - Khaw,Peng Tee, PY - 2004/5/26/pubmed PY - 2004/6/21/medline PY - 2004/5/26/entrez SP - 1711 EP - 20 JF - Lancet (London, England) JO - Lancet VL - 363 IS - 9422 N2 - Primary open-angle glaucoma is a progressive optic neuropathy and, perhaps, the most common form of glaucoma. Because the disease is treatable, and because the visual impairment caused by glaucoma is irreversible, early detection is essential. Early diagnosis depends on examination of the optic disc, retinal nerve fibre layer, and visual field. New imaging and psychophysical tests can improve both detection and monitoring of the progression of the disease. Recently completed long-term clinical trials provide convincing evidence that lowering intraocular pressure prevents progression at both the early and late stages of the disease. The degree of protection is related to the degree to which intraocular pressure is lowered. Improvements in therapy consist of more effective and better-tolerated drugs to lower intraocular pressure, and more effective surgical procedures. New treatments to directly treat and protect the retinal ganglion cells that are damaged in glaucoma are also in development. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/15158634/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(04)16257-0 DB - PRIME DP - Unbound Medicine ER -