Tags

Type your tag names separated by a space and hit enter

Role of antioxidants in treatment of male infertility: an overview of the literature.

Abstract

Seminal oxidative stress in the male reproductive tract is known to result in peroxidative damage of the sperm plasma membrane and loss of its DNA integrity. Normally, a balance exists between concentrations of reactive oxygen species and antioxidant scavenging systems. One of the rational strategies to counteract the oxidative stress is to increase the scavenging capacity of seminal plasma. Numerous studies have evaluated the efficacy of antioxidants in male infertility. In this review, the results of different studies conducted have been analysed, and the evidence available to date is provided. It was found that although many clinical trials have demonstrated the beneficial effects of antioxidants in selected cases of male infertility, some studies failed to demonstrate the same benefit. The majority of the studies suffer from a lack of placebo-controlled, double-blind design, making it difficult to reach a definite conclusion. In addition, investigators have used different antioxidants in different combinations and dosages for varying durations. Pregnancy, the most relevant outcome parameter of fertility, was reported in only a few studies. Most studies failed to examine the effect of antioxidants on a specific group of infertile patients with high oxidative stress. Multicentre, double-blind studies with statistically accepted sample size are still needed to provide conclusive evidence on the benefit of antioxidants as a treatment modality for patients with male infertility.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centre for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Dept. of Obstetrics and Gynecology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A19.1, Cleveland, OH, USA. agarwaa@ccf.org

    , ,

    Source

    Reproductive biomedicine online 8:6 2004 Jun pg 616-27

    MeSH

    Antioxidants
    Humans
    Infertility, Male
    Male

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15169573

    Citation

    Agarwal, Ashok, et al. "Role of Antioxidants in Treatment of Male Infertility: an Overview of the Literature." Reproductive Biomedicine Online, vol. 8, no. 6, 2004, pp. 616-27.
    Agarwal A, Nallella KP, Allamaneni SS, et al. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomed Online. 2004;8(6):616-27.
    Agarwal, A., Nallella, K. P., Allamaneni, S. S., & Said, T. M. (2004). Role of antioxidants in treatment of male infertility: an overview of the literature. Reproductive Biomedicine Online, 8(6), pp. 616-27.
    Agarwal A, et al. Role of Antioxidants in Treatment of Male Infertility: an Overview of the Literature. Reprod Biomed Online. 2004;8(6):616-27. PubMed PMID: 15169573.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of antioxidants in treatment of male infertility: an overview of the literature. AU - Agarwal,Ashok, AU - Nallella,Kiran P, AU - Allamaneni,Shyam S R, AU - Said,Tamer M, PY - 2004/6/1/pubmed PY - 2004/7/9/medline PY - 2004/6/1/entrez SP - 616 EP - 27 JF - Reproductive biomedicine online JO - Reprod. Biomed. Online VL - 8 IS - 6 N2 - Seminal oxidative stress in the male reproductive tract is known to result in peroxidative damage of the sperm plasma membrane and loss of its DNA integrity. Normally, a balance exists between concentrations of reactive oxygen species and antioxidant scavenging systems. One of the rational strategies to counteract the oxidative stress is to increase the scavenging capacity of seminal plasma. Numerous studies have evaluated the efficacy of antioxidants in male infertility. In this review, the results of different studies conducted have been analysed, and the evidence available to date is provided. It was found that although many clinical trials have demonstrated the beneficial effects of antioxidants in selected cases of male infertility, some studies failed to demonstrate the same benefit. The majority of the studies suffer from a lack of placebo-controlled, double-blind design, making it difficult to reach a definite conclusion. In addition, investigators have used different antioxidants in different combinations and dosages for varying durations. Pregnancy, the most relevant outcome parameter of fertility, was reported in only a few studies. Most studies failed to examine the effect of antioxidants on a specific group of infertile patients with high oxidative stress. Multicentre, double-blind studies with statistically accepted sample size are still needed to provide conclusive evidence on the benefit of antioxidants as a treatment modality for patients with male infertility. SN - 1472-6483 UR - https://www.unboundmedicine.com/medline/citation/15169573/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(10)61641-0 DB - PRIME DP - Unbound Medicine ER -