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Support of the metabolic response to burn injury.
Lancet 2004; 363(9424):1895-902Lct

Abstract

Severe burn causes metabolic disturbances that can last for a year after injury; persistent and profound catabolism hampers rehabilitative efforts and delays the meaningful return of individuals to society. The simplest, effective anabolic strategies for severe burn injuries are: early excision and grafting of the wound; prompt treatment of sepsis; maintenance of environmental temperature at 30-32 degrees C; continuous feeding of a high carbohydrate, high protein diet, preferably by the enteral route; and early institution of vigorous and aerobic resistive exercise programmes. To further keep erosion of lean body mass to a minimum, administration of anabolic agents, recombinant human growth hormone, insulin, oxandrolone, or anticatabolic drugs such as propranolol are alternative approaches. Exogenous continuous low-dose insulin infusion, beta blockade with propranolol, and use of the synthetic testosterone analogue oxandrolone are the most cost effective and least toxic pharmacological treatments to date.

Authors+Show Affiliations

Shriners Hospital for Children, 815 Market Street, Galveston, TX 77550, USA. dherndon@utmb.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15183630

Citation

Herndon, David N., and Ronald G. Tompkins. "Support of the Metabolic Response to Burn Injury." Lancet (London, England), vol. 363, no. 9424, 2004, pp. 1895-902.
Herndon DN, Tompkins RG. Support of the metabolic response to burn injury. Lancet. 2004;363(9424):1895-902.
Herndon, D. N., & Tompkins, R. G. (2004). Support of the metabolic response to burn injury. Lancet (London, England), 363(9424), pp. 1895-902.
Herndon DN, Tompkins RG. Support of the Metabolic Response to Burn Injury. Lancet. 2004 Jun 5;363(9424):1895-902. PubMed PMID: 15183630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Support of the metabolic response to burn injury. AU - Herndon,David N, AU - Tompkins,Ronald G, PY - 2004/6/9/pubmed PY - 2004/6/24/medline PY - 2004/6/9/entrez SP - 1895 EP - 902 JF - Lancet (London, England) JO - Lancet VL - 363 IS - 9424 N2 - Severe burn causes metabolic disturbances that can last for a year after injury; persistent and profound catabolism hampers rehabilitative efforts and delays the meaningful return of individuals to society. The simplest, effective anabolic strategies for severe burn injuries are: early excision and grafting of the wound; prompt treatment of sepsis; maintenance of environmental temperature at 30-32 degrees C; continuous feeding of a high carbohydrate, high protein diet, preferably by the enteral route; and early institution of vigorous and aerobic resistive exercise programmes. To further keep erosion of lean body mass to a minimum, administration of anabolic agents, recombinant human growth hormone, insulin, oxandrolone, or anticatabolic drugs such as propranolol are alternative approaches. Exogenous continuous low-dose insulin infusion, beta blockade with propranolol, and use of the synthetic testosterone analogue oxandrolone are the most cost effective and least toxic pharmacological treatments to date. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/15183630/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(04)16360-5 DB - PRIME DP - Unbound Medicine ER -