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Effects of a high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer.

Abstract

PURPOSE

Diet intervention trials are testing whether postdiagnosis dietary modification can influence breast cancer recurrence and survival. One possible mechanism is an effect on reproductive steroid hormones.

PARTICIPANTS AND METHODS

Serum reproductive steroid hormones were measured at enrollment and 1 year in 291 women with a history of breast cancer who were enrolled onto a randomized, controlled diet intervention trial. Dietary goals for the intervention group were increased fiber, vegetable, and fruit intakes and reduced fat intake. Estradiol, bioavailable estradiol, estrone, estrone sulfate, androstenedione, testosterone, dehydroepiandrosterone sulfate, follicle-stimulating hormone, and sex hormone-binding globulin were measured.

RESULTS

The intervention (but not the comparison) group reported a significantly lower intake of energy from fat (21% v 28%), and higher intake of fiber (29 g/d v 22 g/d), at 1-year follow-up (P <.001). Significant weight loss did not occur in either group. A significant difference in the change in bioavailable estradiol concentration from baseline to 1 year in the intervention (-13 pmol/L) versus the comparison (+3 pmol/L) group was observed (P <.05). Change in fiber (but not fat) intake was significantly and independently related to change in serum bioavailable estradiol (P <.01) and total estradiol (P <.05) concentrations.

CONCLUSION

Results from this study indicate that a high-fiber, low-fat diet intervention is associated with reduced serum bioavailable estradiol concentration in women diagnosed with breast cancer, the majority of whom did not exhibit weight loss. Increased fiber intake was independently related to the reduction in serum estradiol concentration.

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  • Authors+Show Affiliations

    ,

    Department of Family and Preventive Medicine, University of California San Diego, CA 92093-0901, USA. clrock@ucsd.edu

    , , , , , , , , ,

    Source

    MeSH

    Breast Neoplasms
    Dietary Fats
    Dietary Fiber
    Estradiol
    Female
    Humans
    Middle Aged
    Motor Activity
    Neoplasm Recurrence, Local
    Vegetables
    Weight Loss

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15197199

    Citation

    Rock, Cheryl L., et al. "Effects of a High-fiber, Low-fat Diet Intervention On Serum Concentrations of Reproductive Steroid Hormones in Women With a History of Breast Cancer." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 22, no. 12, 2004, pp. 2379-87.
    Rock CL, Flatt SW, Thomson CA, et al. Effects of a high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer. J Clin Oncol. 2004;22(12):2379-87.
    Rock, C. L., Flatt, S. W., Thomson, C. A., Stefanick, M. L., Newman, V. A., Jones, L. A., ... Chang, R. J. (2004). Effects of a high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 22(12), pp. 2379-87.
    Rock CL, et al. Effects of a High-fiber, Low-fat Diet Intervention On Serum Concentrations of Reproductive Steroid Hormones in Women With a History of Breast Cancer. J Clin Oncol. 2004 Jun 15;22(12):2379-87. PubMed PMID: 15197199.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of a high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer. AU - Rock,Cheryl L, AU - Flatt,Shirley W, AU - Thomson,Cynthia A, AU - Stefanick,Marcia L, AU - Newman,Vicky A, AU - Jones,Lovell A, AU - Natarajan,Loki, AU - Ritenbaugh,Cheryl, AU - Hollenbach,Kathryn A, AU - Pierce,John P, AU - Chang,R Jeffrey, PY - 2004/6/16/pubmed PY - 2004/6/30/medline PY - 2004/6/16/entrez SP - 2379 EP - 87 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 22 IS - 12 N2 - PURPOSE: Diet intervention trials are testing whether postdiagnosis dietary modification can influence breast cancer recurrence and survival. One possible mechanism is an effect on reproductive steroid hormones. PARTICIPANTS AND METHODS: Serum reproductive steroid hormones were measured at enrollment and 1 year in 291 women with a history of breast cancer who were enrolled onto a randomized, controlled diet intervention trial. Dietary goals for the intervention group were increased fiber, vegetable, and fruit intakes and reduced fat intake. Estradiol, bioavailable estradiol, estrone, estrone sulfate, androstenedione, testosterone, dehydroepiandrosterone sulfate, follicle-stimulating hormone, and sex hormone-binding globulin were measured. RESULTS: The intervention (but not the comparison) group reported a significantly lower intake of energy from fat (21% v 28%), and higher intake of fiber (29 g/d v 22 g/d), at 1-year follow-up (P <.001). Significant weight loss did not occur in either group. A significant difference in the change in bioavailable estradiol concentration from baseline to 1 year in the intervention (-13 pmol/L) versus the comparison (+3 pmol/L) group was observed (P <.05). Change in fiber (but not fat) intake was significantly and independently related to change in serum bioavailable estradiol (P <.01) and total estradiol (P <.05) concentrations. CONCLUSION: Results from this study indicate that a high-fiber, low-fat diet intervention is associated with reduced serum bioavailable estradiol concentration in women diagnosed with breast cancer, the majority of whom did not exhibit weight loss. Increased fiber intake was independently related to the reduction in serum estradiol concentration. SN - 0732-183X UR - https://www.unboundmedicine.com/medline/citation/15197199/full_citation L2 - http://ascopubs.org/doi/full/10.1200/JCO.2004.09.025?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -