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Hereditary breast and ovarian cancer: what the primary care physician should know.

Abstract

In recent years, testing for cancer susceptibility genes has entered the clinical setting. The practicing physician needs to be familiar with this evolving area of medicine to be able to counsel and/or refer high-risk patients such as those with a strong personal or family history of cancer. The following is a review of the clinically pertinent information regarding hereditary breast and ovarian cancers resulting from mutations in BRCA genes. A special emphasis is placed on the different options available for BRCA mutation carriers, because many interventions have already proven to be highly efficacious. The increased risk of cancer seen in hereditary nonpolyposis colorectal cancer (HNPCC) is not part of this review but is mentioned briefly.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics & Gynecology, Lutheran Medical Center, Brooklyn, New York, USA. fcollado@lmcmc.com

    Source

    Obstetrical & gynecological survey 59:7 2004 Jul pg 537-42

    MeSH

    Adult
    Aged
    Breast Neoplasms
    Colorectal Neoplasms, Hereditary Nonpolyposis
    Contraceptives, Oral
    Female
    Genes, BRCA1
    Genetic Counseling
    Gynecologic Surgical Procedures
    Heterozygote
    Humans
    Mass Screening
    Mastectomy
    Middle Aged
    Ovarian Neoplasms
    Primary Health Care
    Risk Assessment
    Tamoxifen

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15199272

    Citation

    Khoury-Collado, Fady, and Allan T. Bombard. "Hereditary Breast and Ovarian Cancer: what the Primary Care Physician Should Know." Obstetrical & Gynecological Survey, vol. 59, no. 7, 2004, pp. 537-42.
    Khoury-Collado F, Bombard AT. Hereditary breast and ovarian cancer: what the primary care physician should know. Obstet Gynecol Surv. 2004;59(7):537-42.
    Khoury-Collado, F., & Bombard, A. T. (2004). Hereditary breast and ovarian cancer: what the primary care physician should know. Obstetrical & Gynecological Survey, 59(7), pp. 537-42.
    Khoury-Collado F, Bombard AT. Hereditary Breast and Ovarian Cancer: what the Primary Care Physician Should Know. Obstet Gynecol Surv. 2004;59(7):537-42. PubMed PMID: 15199272.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hereditary breast and ovarian cancer: what the primary care physician should know. AU - Khoury-Collado,Fady, AU - Bombard,Allan T, PY - 2004/6/17/pubmed PY - 2004/9/24/medline PY - 2004/6/17/entrez SP - 537 EP - 42 JF - Obstetrical & gynecological survey JO - Obstet Gynecol Surv VL - 59 IS - 7 N2 - In recent years, testing for cancer susceptibility genes has entered the clinical setting. The practicing physician needs to be familiar with this evolving area of medicine to be able to counsel and/or refer high-risk patients such as those with a strong personal or family history of cancer. The following is a review of the clinically pertinent information regarding hereditary breast and ovarian cancers resulting from mutations in BRCA genes. A special emphasis is placed on the different options available for BRCA mutation carriers, because many interventions have already proven to be highly efficacious. The increased risk of cancer seen in hereditary nonpolyposis colorectal cancer (HNPCC) is not part of this review but is mentioned briefly. SN - 0029-7828 UR - https://www.unboundmedicine.com/medline/citation/15199272/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15199272.ui DB - PRIME DP - Unbound Medicine ER -