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Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis.
Ann Allergy Asthma Immunol 2004; 92(6):654-8AA

Abstract

BACKGROUND

Vitamin E supplementation is widely used in clinical practice for the prevention and treatment of different medical conditions. Evidence from basic science studies suggests that vitamin E may reduce immune allergic responses. However, only a few clinical studies of the effect of vitamin E on allergic conditions have been performed in patients with atopic dermatitis and asthma, and none have been performed in patients with allergic rhinitis.

OBJECTIVE

To determine the effect of high-dose vitamin E supplementation in combination with the usual ("real-life") treatment on the symptoms of seasonal allergic rhinitis during the pollen season.

METHODS

In a double-blind, placebo-controlled, randomized study, 112 patients with documented hay fever received either vitamin E (800 mg/d) or placebo in addition to their regular antiallergic treatment during the pollen season. Patients recorded their daily nasal and eye symptoms and their daily need for other medications to control allergic symptoms.

RESULTS

Although no effect was observed on ocular symptoms, nasal symptom scores were lower in patients who received vitamin E supplementation during the hay fever season. However, there was no reduction in the percentage of days with serious symptoms or in the percentage of days that medications were used to control allergic symptoms during the pollen season.

CONCLUSIONS

Vitamin E supplementation may be a valuable addition to the treatment of patients with seasonal allergic rhinitis. However, further clinical and basic science studies are needed to determine its real value.

Authors+Show Affiliations

Institute of Allergy, Clinical Immunology, and AIDS, Rambam Medical Center, Haifa, Israel. ed_shahar@rambam.health.gov.ilNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15237767

Citation

Shahar, Eduardo, et al. "Effect of Vitamin E Supplementation On the Regular Treatment of Seasonal Allergic Rhinitis." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 92, no. 6, 2004, pp. 654-8.
Shahar E, Hassoun G, Pollack S. Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2004;92(6):654-8.
Shahar, E., Hassoun, G., & Pollack, S. (2004). Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 92(6), pp. 654-8.
Shahar E, Hassoun G, Pollack S. Effect of Vitamin E Supplementation On the Regular Treatment of Seasonal Allergic Rhinitis. Ann Allergy Asthma Immunol. 2004;92(6):654-8. PubMed PMID: 15237767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. AU - Shahar,Eduardo, AU - Hassoun,Gamal, AU - Pollack,Shimon, PY - 2004/7/9/pubmed PY - 2004/8/4/medline PY - 2004/7/9/entrez SP - 654 EP - 8 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 92 IS - 6 N2 - BACKGROUND: Vitamin E supplementation is widely used in clinical practice for the prevention and treatment of different medical conditions. Evidence from basic science studies suggests that vitamin E may reduce immune allergic responses. However, only a few clinical studies of the effect of vitamin E on allergic conditions have been performed in patients with atopic dermatitis and asthma, and none have been performed in patients with allergic rhinitis. OBJECTIVE: To determine the effect of high-dose vitamin E supplementation in combination with the usual ("real-life") treatment on the symptoms of seasonal allergic rhinitis during the pollen season. METHODS: In a double-blind, placebo-controlled, randomized study, 112 patients with documented hay fever received either vitamin E (800 mg/d) or placebo in addition to their regular antiallergic treatment during the pollen season. Patients recorded their daily nasal and eye symptoms and their daily need for other medications to control allergic symptoms. RESULTS: Although no effect was observed on ocular symptoms, nasal symptom scores were lower in patients who received vitamin E supplementation during the hay fever season. However, there was no reduction in the percentage of days with serious symptoms or in the percentage of days that medications were used to control allergic symptoms during the pollen season. CONCLUSIONS: Vitamin E supplementation may be a valuable addition to the treatment of patients with seasonal allergic rhinitis. However, further clinical and basic science studies are needed to determine its real value. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/15237767/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)61432-9 DB - PRIME DP - Unbound Medicine ER -