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Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy.

Abstract

The risk of infantile atopic dermatitis (AD) posed by maternal atopy and paternal atopy, respectively, were compared in the infants from a birth cohort in whom one of the parents had been designated atopic by skin prick testing. Nineteen with atopic mothers were compared with 20 with atopic fathers. AD, other atopic manifestations and potentially influential factors such as breast-feeding were documented prospectively during the first year in all infants. At 3, 6 and 12 month assessments skin prick sensitivity and total serum IgE concentration were determined. Nine of 19 infants with atopic mothers and two of 20 with atopic fathers had AD (P = 0.023) giving a relative risk of 4.7 (95% confidence interval 2.5 to 9.0). Seven of 19 with atopic mothers and none with atopic fathers had AD with onset before 6 months (P = 0.007). When all types of disease evidence (AD, recurrent wheeze and food reactions) were analysed together no significant difference was apparent between the groups. The two groups were found to be well matched with regard to breast-feeding, time of starting cow's milk, solids and egg, sex, month of birth, parental AD and smoking, race, household pets and neonatal IgE concentration. IgE concentrations at each age and the prevalence of skin prick positivity were similar between the groups. Maternal atopy poses a higher risk for infantile AD and paternal atopy. Whether this may be due to genetic or congenital factors or both is uncertain, but clearly the finding is of relevance in the prediction of allergy in childhood.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Child Health, King's College School of Medicine and Dentistry, Denmark Hill, London.

    ,

    Source

    MeSH

    Adult
    Dermatitis, Atopic
    Fathers
    Female
    Humans
    Hypersensitivity
    Infant
    Male
    Mothers
    Pregnancy
    Pregnancy Complications
    Risk
    Sex Factors
    Skin Tests

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    1525695

    Citation

    Ruiz, R G., et al. "Higher Risk of Infantile Atopic Dermatitis From Maternal Atopy Than From Paternal Atopy." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 22, no. 8, 1992, pp. 762-6.
    Ruiz RG, Kemeny DM, Price JF. Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy. Clin Exp Allergy. 1992;22(8):762-6.
    Ruiz, R. G., Kemeny, D. M., & Price, J. F. (1992). Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 22(8), pp. 762-6.
    Ruiz RG, Kemeny DM, Price JF. Higher Risk of Infantile Atopic Dermatitis From Maternal Atopy Than From Paternal Atopy. Clin Exp Allergy. 1992;22(8):762-6. PubMed PMID: 1525695.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy. AU - Ruiz,R G, AU - Kemeny,D M, AU - Price,J F, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 762 EP - 6 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 22 IS - 8 N2 - The risk of infantile atopic dermatitis (AD) posed by maternal atopy and paternal atopy, respectively, were compared in the infants from a birth cohort in whom one of the parents had been designated atopic by skin prick testing. Nineteen with atopic mothers were compared with 20 with atopic fathers. AD, other atopic manifestations and potentially influential factors such as breast-feeding were documented prospectively during the first year in all infants. At 3, 6 and 12 month assessments skin prick sensitivity and total serum IgE concentration were determined. Nine of 19 infants with atopic mothers and two of 20 with atopic fathers had AD (P = 0.023) giving a relative risk of 4.7 (95% confidence interval 2.5 to 9.0). Seven of 19 with atopic mothers and none with atopic fathers had AD with onset before 6 months (P = 0.007). When all types of disease evidence (AD, recurrent wheeze and food reactions) were analysed together no significant difference was apparent between the groups. The two groups were found to be well matched with regard to breast-feeding, time of starting cow's milk, solids and egg, sex, month of birth, parental AD and smoking, race, household pets and neonatal IgE concentration. IgE concentrations at each age and the prevalence of skin prick positivity were similar between the groups. Maternal atopy poses a higher risk for infantile AD and paternal atopy. Whether this may be due to genetic or congenital factors or both is uncertain, but clearly the finding is of relevance in the prediction of allergy in childhood. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/1525695/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=1992&volume=22&issue=8&spage=762 DB - PRIME DP - Unbound Medicine ER -