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Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States).

Abstract

OBJECTIVE

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and the second most common cause of mortality in children aged 1-14 years. Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for ALL.

METHODS

The Northern California Childhood Leukemia Study is a population-based case-control study of risk factors for childhood leukemia, including maternal diet. Cases (n = 138) and controls (n = 138) were matched on sex, date of birth, mother's race, Hispanicity, and county of residence at birth. Maternal dietary intake in the 12 months prior to pregnancy was obtained by a 76-item food frequency questionnaire.

RESULTS

Consumption of the vegetables (OR = 0.53; 95% CI, 0.33-0.85; p = 0.008), protein sources (OR = 0.40; 95% CI, 0.18-0.90, p = 0.03), and fruits (OR = 0.71; 95% CI, 0.49-1.04; p = 0.08) food groups were inversely associated with ALL. Among nutrients, consumption of provitamin A carotenoids (OR = 0.65, 95% CI, 0.42-1.01; p = 0.05), and the antioxidant glutathione (OR = 0.42; 95% CI, 0.16-1.10; p = 0.08) were inversely associated with ALL.

CONCLUSION

Maternal dietary factors, specifically the consumption of vegetables, fruits, protein sources and related nutrients, may play a role in the etiology of ALL. Dietary carotenoids and glutathione appear to be important contributors to this effect.

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  • Authors+Show Affiliations

    ,

    School of Public Health, 419 Warren Hall, University of California, Berkeley, CA 94720-7360, USA. cjensen@berkeley.edu

    , , , ,

    Source

    Cancer causes & control : CCC 15:6 2004 Aug pg 559-70

    MeSH

    Adolescent
    Adult
    Case-Control Studies
    Child
    Child, Preschool
    Diet
    Dietary Proteins
    Female
    Fruit
    Humans
    Male
    Maternal Exposure
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Pregnancy
    Prenatal Exposure Delayed Effects
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15280635

    Citation

    Jensen, Christopher D., et al. "Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)." Cancer Causes & Control : CCC, vol. 15, no. 6, 2004, pp. 559-70.
    Jensen CD, Block G, Buffler P, et al. Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes Control. 2004;15(6):559-70.
    Jensen, C. D., Block, G., Buffler, P., Ma, X., Selvin, S., & Month, S. (2004). Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes & Control : CCC, 15(6), pp. 559-70.
    Jensen CD, et al. Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States). Cancer Causes Control. 2004;15(6):559-70. PubMed PMID: 15280635.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). AU - Jensen,Christopher D, AU - Block,Gladys, AU - Buffler,Patricia, AU - Ma,Xiaomei, AU - Selvin,Steve, AU - Month,Stacy, PY - 2004/7/29/pubmed PY - 2004/11/17/medline PY - 2004/7/29/entrez SP - 559 EP - 70 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 15 IS - 6 N2 - OBJECTIVE: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and the second most common cause of mortality in children aged 1-14 years. Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for ALL. METHODS: The Northern California Childhood Leukemia Study is a population-based case-control study of risk factors for childhood leukemia, including maternal diet. Cases (n = 138) and controls (n = 138) were matched on sex, date of birth, mother's race, Hispanicity, and county of residence at birth. Maternal dietary intake in the 12 months prior to pregnancy was obtained by a 76-item food frequency questionnaire. RESULTS: Consumption of the vegetables (OR = 0.53; 95% CI, 0.33-0.85; p = 0.008), protein sources (OR = 0.40; 95% CI, 0.18-0.90, p = 0.03), and fruits (OR = 0.71; 95% CI, 0.49-1.04; p = 0.08) food groups were inversely associated with ALL. Among nutrients, consumption of provitamin A carotenoids (OR = 0.65, 95% CI, 0.42-1.01; p = 0.05), and the antioxidant glutathione (OR = 0.42; 95% CI, 0.16-1.10; p = 0.08) were inversely associated with ALL. CONCLUSION: Maternal dietary factors, specifically the consumption of vegetables, fruits, protein sources and related nutrients, may play a role in the etiology of ALL. Dietary carotenoids and glutathione appear to be important contributors to this effect. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/15280635/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15280635.ui DB - PRIME DP - Unbound Medicine ER -