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Lycopene: modes of action to promote prostate health.

Abstract

Epidemiological evidence strongly suggests that lycopene consumption contributes to prostate cancer risk reduction. Preclinical studies show that lycopene acts via different mechanisms, which have the potential to cooperate in reducing the proliferation of normal and cancerous prostate epithelial cells, in reducing DNA damage, and in improving oxidative stress defense. The mechanisms include inhibition of prostatic IGF-I signaling, IL-6 expression, and androgen signaling. Moreover, lycopene improves gap-junctional communication and induces phase II drug metabolizing enzymes as well as oxidative defense genes. These findings provide plausible explanations for the epidemiological findings how lycopene can contribute to reduced prostate cancer risk. The novel finding that lycopene reduces local androgen signaling in the prostate suggests also efficacy in prevention of benign prostate hyperplasia. Intervention trials in humans are required to finally prove clinical efficacy of the lycopene molecule in prostate health.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    DSM Nutritional Products, Human Nutrition and Health, Carotenoid Section, Basel, Switzerland. karin.wertz@dsm.com

    ,

    Source

    Archives of biochemistry and biophysics 430:1 2004 Oct 01 pg 127-34

    MeSH

    Animals
    Anticarcinogenic Agents
    Apoptosis
    Carotenoids
    Cell Cycle
    Disease Models, Animal
    Humans
    Insulin-Like Growth Factor I
    Lycopene
    Male
    Prostate
    Prostatic Neoplasms
    Signal Transduction

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15325920

    Citation

    Wertz, Karin, et al. "Lycopene: Modes of Action to Promote Prostate Health." Archives of Biochemistry and Biophysics, vol. 430, no. 1, 2004, pp. 127-34.
    Wertz K, Siler U, Goralczyk R. Lycopene: modes of action to promote prostate health. Arch Biochem Biophys. 2004;430(1):127-34.
    Wertz, K., Siler, U., & Goralczyk, R. (2004). Lycopene: modes of action to promote prostate health. Archives of Biochemistry and Biophysics, 430(1), pp. 127-34.
    Wertz K, Siler U, Goralczyk R. Lycopene: Modes of Action to Promote Prostate Health. Arch Biochem Biophys. 2004 Oct 1;430(1):127-34. PubMed PMID: 15325920.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lycopene: modes of action to promote prostate health. AU - Wertz,Karin, AU - Siler,Ulrich, AU - Goralczyk,Regina, PY - 2004/01/13/received PY - 2004/04/15/revised PY - 2004/8/25/pubmed PY - 2004/9/24/medline PY - 2004/8/25/entrez SP - 127 EP - 34 JF - Archives of biochemistry and biophysics JO - Arch. Biochem. Biophys. VL - 430 IS - 1 N2 - Epidemiological evidence strongly suggests that lycopene consumption contributes to prostate cancer risk reduction. Preclinical studies show that lycopene acts via different mechanisms, which have the potential to cooperate in reducing the proliferation of normal and cancerous prostate epithelial cells, in reducing DNA damage, and in improving oxidative stress defense. The mechanisms include inhibition of prostatic IGF-I signaling, IL-6 expression, and androgen signaling. Moreover, lycopene improves gap-junctional communication and induces phase II drug metabolizing enzymes as well as oxidative defense genes. These findings provide plausible explanations for the epidemiological findings how lycopene can contribute to reduced prostate cancer risk. The novel finding that lycopene reduces local androgen signaling in the prostate suggests also efficacy in prevention of benign prostate hyperplasia. Intervention trials in humans are required to finally prove clinical efficacy of the lycopene molecule in prostate health. SN - 0003-9861 UR - https://www.unboundmedicine.com/medline/citation/15325920/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003986104002620 DB - PRIME DP - Unbound Medicine ER -