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The effect of magnesium on length of stay for pediatric sickle cell pain crisis.
Acad Emerg Med 2004; 11(9):968-72AE

Abstract

OBJECTIVES

To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis.

METHODS

This was a single arm study, with historical controls. Hemoglobin SS or Hemoglobin Sbeta degrees children admitted for pain crisis were eligible. Two sequential treatment protocols of IV magnesium sulfate were added to standard inpatient therapy of IV fluids, opioids, and nonsteroidal anti-inflammatory drugs. The initial 12 children received 40 mg/kg (maximum of 1.5 g) of IV magnesium in the emergency department (ED), and eight and 16 hours later. Seven subsequent children received 40 mg/kg (maximum of 2.5 g) of IV magnesium in the ED, and every eight hours for up to four inpatient days. The main outcome measure was LOS, measured in days. Differences in LOS were analyzed between the admission with magnesium, and the two previous admissions meeting the same criteria, using a Wilcoxon signed-rank test for nonparametric paired data.

RESULTS

Nineteen children were enrolled. The results of the two protocols were combined for the analysis. A shorter LOS was found on study admissions (median LOS, 3.0 days compared with 5.0 and 4.0 days for the previous two admissions; p = 0.006).

CONCLUSIONS

IV magnesium appears to decrease the LOS for children with sickle cell pain crisis.

Authors+Show Affiliations

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. dbrousse@mail.mcw.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15347549

Citation

Brousseau, David C., et al. "The Effect of Magnesium On Length of Stay for Pediatric Sickle Cell Pain Crisis." Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, vol. 11, no. 9, 2004, pp. 968-72.
Brousseau DC, Scott JP, Hillery CA, et al. The effect of magnesium on length of stay for pediatric sickle cell pain crisis. Acad Emerg Med. 2004;11(9):968-72.
Brousseau, D. C., Scott, J. P., Hillery, C. A., & Panepinto, J. A. (2004). The effect of magnesium on length of stay for pediatric sickle cell pain crisis. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, 11(9), pp. 968-72.
Brousseau DC, et al. The Effect of Magnesium On Length of Stay for Pediatric Sickle Cell Pain Crisis. Acad Emerg Med. 2004;11(9):968-72. PubMed PMID: 15347549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of magnesium on length of stay for pediatric sickle cell pain crisis. AU - Brousseau,David C, AU - Scott,J Paul, AU - Hillery,Cheryl A, AU - Panepinto,Julie A, PY - 2004/9/7/pubmed PY - 2004/12/16/medline PY - 2004/9/7/entrez SP - 968 EP - 72 JF - Academic emergency medicine : official journal of the Society for Academic Emergency Medicine JO - Acad Emerg Med VL - 11 IS - 9 N2 - OBJECTIVES: To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis. METHODS: This was a single arm study, with historical controls. Hemoglobin SS or Hemoglobin Sbeta degrees children admitted for pain crisis were eligible. Two sequential treatment protocols of IV magnesium sulfate were added to standard inpatient therapy of IV fluids, opioids, and nonsteroidal anti-inflammatory drugs. The initial 12 children received 40 mg/kg (maximum of 1.5 g) of IV magnesium in the emergency department (ED), and eight and 16 hours later. Seven subsequent children received 40 mg/kg (maximum of 2.5 g) of IV magnesium in the ED, and every eight hours for up to four inpatient days. The main outcome measure was LOS, measured in days. Differences in LOS were analyzed between the admission with magnesium, and the two previous admissions meeting the same criteria, using a Wilcoxon signed-rank test for nonparametric paired data. RESULTS: Nineteen children were enrolled. The results of the two protocols were combined for the analysis. A shorter LOS was found on study admissions (median LOS, 3.0 days compared with 5.0 and 4.0 days for the previous two admissions; p = 0.006). CONCLUSIONS: IV magnesium appears to decrease the LOS for children with sickle cell pain crisis. SN - 1069-6563 UR - https://www.unboundmedicine.com/medline/citation/15347549/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1069-6563&date=2004&volume=11&issue=9&spage=968 DB - PRIME DP - Unbound Medicine ER -