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The effect of magnesium on length of stay for pediatric sickle cell pain crisis.

Abstract

OBJECTIVES

To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis.

METHODS

This was a single arm study, with historical controls. Hemoglobin SS or Hemoglobin Sbeta degrees children admitted for pain crisis were eligible. Two sequential treatment protocols of IV magnesium sulfate were added to standard inpatient therapy of IV fluids, opioids, and nonsteroidal anti-inflammatory drugs. The initial 12 children received 40 mg/kg (maximum of 1.5 g) of IV magnesium in the emergency department (ED), and eight and 16 hours later. Seven subsequent children received 40 mg/kg (maximum of 2.5 g) of IV magnesium in the ED, and every eight hours for up to four inpatient days. The main outcome measure was LOS, measured in days. Differences in LOS were analyzed between the admission with magnesium, and the two previous admissions meeting the same criteria, using a Wilcoxon signed-rank test for nonparametric paired data.

RESULTS

Nineteen children were enrolled. The results of the two protocols were combined for the analysis. A shorter LOS was found on study admissions (median LOS, 3.0 days compared with 5.0 and 4.0 days for the previous two admissions; p = 0.006).

CONCLUSIONS

IV magnesium appears to decrease the LOS for children with sickle cell pain crisis.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. dbrousse@mail.mcw.edu

    , ,

    Source

    MeSH

    Adolescent
    Anemia, Sickle Cell
    Child
    Child, Preschool
    Drug Administration Schedule
    Emergency Service, Hospital
    Female
    Humans
    Infusions, Intravenous
    Length of Stay
    Magnesium
    Male
    Pain

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15347549

    Citation

    TY - JOUR T1 - The effect of magnesium on length of stay for pediatric sickle cell pain crisis. AU - Brousseau,David C, AU - Scott,J Paul, AU - Hillery,Cheryl A, AU - Panepinto,Julie A, PY - 2004/9/7/pubmed PY - 2004/12/16/medline PY - 2004/9/7/entrez SP - 968 EP - 72 JF - Academic emergency medicine : official journal of the Society for Academic Emergency Medicine JO - Acad Emerg Med VL - 11 IS - 9 N2 - OBJECTIVES: To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis. METHODS: This was a single arm study, with historical controls. Hemoglobin SS or Hemoglobin Sbeta degrees children admitted for pain crisis were eligible. Two sequential treatment protocols of IV magnesium sulfate were added to standard inpatient therapy of IV fluids, opioids, and nonsteroidal anti-inflammatory drugs. The initial 12 children received 40 mg/kg (maximum of 1.5 g) of IV magnesium in the emergency department (ED), and eight and 16 hours later. Seven subsequent children received 40 mg/kg (maximum of 2.5 g) of IV magnesium in the ED, and every eight hours for up to four inpatient days. The main outcome measure was LOS, measured in days. Differences in LOS were analyzed between the admission with magnesium, and the two previous admissions meeting the same criteria, using a Wilcoxon signed-rank test for nonparametric paired data. RESULTS: Nineteen children were enrolled. The results of the two protocols were combined for the analysis. A shorter LOS was found on study admissions (median LOS, 3.0 days compared with 5.0 and 4.0 days for the previous two admissions; p = 0.006). CONCLUSIONS: IV magnesium appears to decrease the LOS for children with sickle cell pain crisis. SN - 1069-6563 UR - https://www.unboundmedicine.com/medline/citation/15347549/full_citation L2 - http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1069-6563&date=2004&volume=11&issue=9&spage=968 ER -