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Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease.
Muscle Nerve 2005; 31(2):260-5MN

Abstract

We report a patient with late-onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti-gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion-body myopathy in the muscle.

Authors+Show Affiliations

Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, P.O. Box 23462, Nicosia, Cyprus.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15389648

Citation

Kleopa, Kleopas A., et al. "Reversible Inflammatory and Vacuolar Myopathy With Vitamin E Deficiency in Celiac Disease." Muscle & Nerve, vol. 31, no. 2, 2005, pp. 260-5.
Kleopa KA, Kyriacou K, Zamba-Papanicolaou E, et al. Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. Muscle Nerve. 2005;31(2):260-5.
Kleopa, K. A., Kyriacou, K., Zamba-Papanicolaou, E., & Kyriakides, T. (2005). Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. Muscle & Nerve, 31(2), pp. 260-5.
Kleopa KA, et al. Reversible Inflammatory and Vacuolar Myopathy With Vitamin E Deficiency in Celiac Disease. Muscle Nerve. 2005;31(2):260-5. PubMed PMID: 15389648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. AU - Kleopa,Kleopas A, AU - Kyriacou,Kyriacos, AU - Zamba-Papanicolaou,Eleni, AU - Kyriakides,Theodoros, PY - 2004/9/25/pubmed PY - 2005/3/11/medline PY - 2004/9/25/entrez SP - 260 EP - 5 JF - Muscle & nerve JO - Muscle Nerve VL - 31 IS - 2 N2 - We report a patient with late-onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti-gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion-body myopathy in the muscle. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/15389648/full_citation L2 - https://doi.org/10.1002/mus.20144 DB - PRIME DP - Unbound Medicine ER -