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Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease.

Abstract

We report a patient with late-onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti-gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion-body myopathy in the muscle.

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    Authors+Show Affiliations

    Kleopa KA
    ,

    Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, P.O. Box 23462, Nicosia, Cyprus.

    Kyriacou K
    ,
    Zamba-Papanicolaou E
    ,
    Kyriakides T

    Source

    Muscle & nerve 31:2 2005 Feb pg 260-5

    MeSH

    Aged
    Celiac Disease
    Glutens
    Humans
    Male
    Myositis
    Myositis, Inclusion Body
    Vitamin E
    Vitamin E Deficiency

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    15389648

    Citation

    Kleopa, Kleopas A., et al. "Reversible Inflammatory and Vacuolar Myopathy With Vitamin E Deficiency in Celiac Disease." Muscle & Nerve, vol. 31, no. 2, 2005, pp. 260-5.
    Kleopa KA, Kyriacou K, Zamba-Papanicolaou E, et al. Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. Muscle Nerve. 2005;31(2):260-5.
    Kleopa, K. A., Kyriacou, K., Zamba-Papanicolaou, E., & Kyriakides, T. (2005). Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. Muscle & Nerve, 31(2), pp. 260-5.
    Kleopa KA, et al. Reversible Inflammatory and Vacuolar Myopathy With Vitamin E Deficiency in Celiac Disease. Muscle Nerve. 2005;31(2):260-5. PubMed PMID: 15389648.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. AU - Kleopa,Kleopas A, AU - Kyriacou,Kyriacos, AU - Zamba-Papanicolaou,Eleni, AU - Kyriakides,Theodoros, PY - 2004/9/25/pubmed PY - 2005/3/11/medline PY - 2004/9/25/entrez SP - 260 EP - 5 JF - Muscle & nerve JO - Muscle Nerve VL - 31 IS - 2 N2 - We report a patient with late-onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti-gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion-body myopathy in the muscle. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/15389648/full_citation L2 - https://doi.org/10.1002/mus.20144 DB - PRIME DP - Unbound Medicine ER -