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Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study.

Abstract

OBJECTIVE

Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized that metabolic syndrome itself could confer an increased risk for incident prostate cancer.

METHODS

The participants were a population-based sample of 1,880 men from eastern Finland without history of cancer or diabetes mellitus at baseline.

RESULTS

The metabolic syndrome (WHO criteria) was present in 357 (19%) of subjects. During an average follow-up of 13 years, a total of 183 cancers occurred, of which 56 were due to prostate cancer. The metabolic syndrome at baseline was related to a 1.9-fold (95% confidence interval, 1.1-3.5) risk of prostate cancer after adjustment for age, alcohol consumption, physical fitness, and energy, fat, fiber, calcium, vitamin E, and alpha-linolenic acid intake. The association between metabolic syndrome and risk of prostate cancer was stronger among overweight and obese men with a body mass index > or = 27 kg/m2 (adjusted relative risk, 3.0; 95% confidence interval, 1.2-7.3) than in lighter men (relative risk, 1.8; 95% confidence interval, 0.7-4.7).

CONCLUSIONS

Middle-aged men with the metabolic syndrome were more likely to develop prostate cancer in this prospective population-based study. This finding suggests that efforts to curb the epidemic of overweight and sedentary lifestyle and the accompanying metabolic syndrome may decrease the risk for prostate cancer.

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  • Authors+Show Affiliations

    ,

    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211, Finland. jariantero.laukkanen@uku.fi

    , , , ,

    Source

    MeSH

    Finland
    Humans
    Incidence
    Life Style
    Male
    Metabolic Syndrome
    Middle Aged
    Obesity
    Prospective Studies
    Prostatic Neoplasms
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15466982

    Citation

    Laukkanen, Jari A., et al. "Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: a Population-based Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 10, 2004, pp. 1646-50.
    Laukkanen JA, Laaksonen DE, Niskanen L, et al. Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study. Cancer Epidemiol Biomarkers Prev. 2004;13(10):1646-50.
    Laukkanen, J. A., Laaksonen, D. E., Niskanen, L., Pukkala, E., Hakkarainen, A., & Salonen, J. T. (2004). Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(10), pp. 1646-50.
    Laukkanen JA, et al. Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: a Population-based Study. Cancer Epidemiol Biomarkers Prev. 2004;13(10):1646-50. PubMed PMID: 15466982.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study. AU - Laukkanen,Jari A, AU - Laaksonen,David E, AU - Niskanen,Leo, AU - Pukkala,Eero, AU - Hakkarainen,Anna, AU - Salonen,Jukka T, PY - 2004/10/7/pubmed PY - 2005/1/8/medline PY - 2004/10/7/entrez SP - 1646 EP - 50 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 10 N2 - OBJECTIVE: Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized that metabolic syndrome itself could confer an increased risk for incident prostate cancer. METHODS: The participants were a population-based sample of 1,880 men from eastern Finland without history of cancer or diabetes mellitus at baseline. RESULTS: The metabolic syndrome (WHO criteria) was present in 357 (19%) of subjects. During an average follow-up of 13 years, a total of 183 cancers occurred, of which 56 were due to prostate cancer. The metabolic syndrome at baseline was related to a 1.9-fold (95% confidence interval, 1.1-3.5) risk of prostate cancer after adjustment for age, alcohol consumption, physical fitness, and energy, fat, fiber, calcium, vitamin E, and alpha-linolenic acid intake. The association between metabolic syndrome and risk of prostate cancer was stronger among overweight and obese men with a body mass index > or = 27 kg/m2 (adjusted relative risk, 3.0; 95% confidence interval, 1.2-7.3) than in lighter men (relative risk, 1.8; 95% confidence interval, 0.7-4.7). CONCLUSIONS: Middle-aged men with the metabolic syndrome were more likely to develop prostate cancer in this prospective population-based study. This finding suggests that efforts to curb the epidemic of overweight and sedentary lifestyle and the accompanying metabolic syndrome may decrease the risk for prostate cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15466982/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15466982 DB - PRIME DP - Unbound Medicine ER -