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Serum ionized magnesium levels and ionized calcium-to-magnesium ratios in adult patients with sickle cell anemia.

Abstract

Low levels of total magnesium in sickle cell erythrocytes have been linked to increased sickling due to cell dehydration. We tested the null hypothesis that adult sickle cell anemia (SCA) patients have the same serum level of ionized Mg (Mg(2+)) and Ca(2+)/Mg(2+) ratio as healthy African Americans (AA) and healthy Caucasians (CAUC). We measured serum Mg(2+) and ionized calcium (Ca(2+)) with ion-selective electrodes and calculated the serum Ca(2+)/Mg(2+) ratios in patients with SCA and control groups (AA and CAUC). Seventy-four SCA patients and 61 controls were compared. SCA patients had significantly (P < 0.001) lower levels of serum Mg(2+) (0.52 +/- 0.05) compared to healthy AA (0.57 +/- 0.04) and CAUC (0.62 +/- 0.03). Eighty-six percent of the adult SCA patients had serum Mg(2+) levels below the mean for the AA group, and 96% of SCA patients were above the AA group's mean serum Ca(2+)/Mg(2+). Of the SCA patients studied, 25.6% (95% CI, 16.2-37.2%) had serum Mg(2+) levels below the racially adjusted lower limit of normal and 50% (95% CI, 38.1-61.9%) were above the upper limit of serum Ca(2+)/Mg(2+) for AA controls. By measuring serum Mg(2+) and Ca(2+), we were able to define a subset of SCA patients with hypomagnesemia and elevated Ca(2+)/Mg(2+) ratios, who may benefit from magnesium supplementation.

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  • Authors+Show Affiliations

    ,

    Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA. zehtab@yahoo.com

    , , , , , ,

    Source

    American journal of hematology 77:3 2004 Nov pg 215-22

    MeSH

    Adult
    African Americans
    Anemia, Sickle Cell
    Calcium
    Case-Control Studies
    European Continental Ancestry Group
    Female
    Humans
    Linear Models
    Magnesium
    Male

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    15495259

    Citation

    TY - JOUR T1 - Serum ionized magnesium levels and ionized calcium-to-magnesium ratios in adult patients with sickle cell anemia. AU - Zehtabchi,Shahriar, AU - Sinert,Richard, AU - Rinnert,Stephan, AU - Chang,Betty, AU - Heinis,Christian, AU - Altura,Rachel A, AU - Altura,Bella T, AU - Altura,Burton M, PY - 2004/10/21/pubmed PY - 2005/2/4/medline PY - 2004/10/21/entrez SP - 215 EP - 22 JF - American journal of hematology JO - Am. J. Hematol. VL - 77 IS - 3 N2 - Low levels of total magnesium in sickle cell erythrocytes have been linked to increased sickling due to cell dehydration. We tested the null hypothesis that adult sickle cell anemia (SCA) patients have the same serum level of ionized Mg (Mg(2+)) and Ca(2+)/Mg(2+) ratio as healthy African Americans (AA) and healthy Caucasians (CAUC). We measured serum Mg(2+) and ionized calcium (Ca(2+)) with ion-selective electrodes and calculated the serum Ca(2+)/Mg(2+) ratios in patients with SCA and control groups (AA and CAUC). Seventy-four SCA patients and 61 controls were compared. SCA patients had significantly (P < 0.001) lower levels of serum Mg(2+) (0.52 +/- 0.05) compared to healthy AA (0.57 +/- 0.04) and CAUC (0.62 +/- 0.03). Eighty-six percent of the adult SCA patients had serum Mg(2+) levels below the mean for the AA group, and 96% of SCA patients were above the AA group's mean serum Ca(2+)/Mg(2+). Of the SCA patients studied, 25.6% (95% CI, 16.2-37.2%) had serum Mg(2+) levels below the racially adjusted lower limit of normal and 50% (95% CI, 38.1-61.9%) were above the upper limit of serum Ca(2+)/Mg(2+) for AA controls. By measuring serum Mg(2+) and Ca(2+), we were able to define a subset of SCA patients with hypomagnesemia and elevated Ca(2+)/Mg(2+) ratios, who may benefit from magnesium supplementation. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/15495259/full_citation L2 - http://dx.doi.org/10.1002/ajh.20187 ER -