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Psychosocial factors and the response to influenza vaccination in older adults.

Abstract

OBJECTIVE

We examined the influence of psychological state (depression, negative affect, perceived stress) and social support on pre- and post-vaccination response to influenza vaccine.

METHODS

Venous blood was drawn from 37 nursing home residents before and following injection of the trivalent influenza vaccine (comprised of the New Caledonia (NC), Hong Kong (HK), and Panama (Pan) strains of flu). The Geriatric Depression Scale, Perceived Stress Scale, Positive and Negative Affect Schedule, and Multidimensional Scale of Perceived Social Support were completed following the initial blood draw.

RESULTS

Social support and perceived stress were correlated with pre-vaccine antibody responses to two of the three vaccine components (HK and NC). Social support was negatively correlated with both pre- and post-vaccine titers to Pan. Depression, positive affect, and negative affect were not related to vaccine response.

CONCLUSIONS

Perceived stress and social support influence the rate of decline of antibody titers to previous exposures to some strains of influenza occurring either naturally or via deliberate vaccination.

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  • Authors

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    Source

    MeSH

    Affect
    Age Factors
    Aged
    Aged, 80 and over
    Antibodies, Viral
    Antibody Formation
    Female
    Geriatric Assessment
    Humans
    Influenza A virus
    Influenza Vaccines
    Influenza, Human
    Male
    Mass Vaccination
    Nursing Homes
    Orthomyxoviridae
    Psychiatric Status Rating Scales
    Social Support
    Stress, Psychological
    Vaccination

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15564363

    Citation

    TY - JOUR T1 - Psychosocial factors and the response to influenza vaccination in older adults. AU - Moynihan,Jan A, AU - Larson,Mark R, AU - Treanor,John, AU - Duberstein,Paul R, AU - Power,Alan, AU - Shore,Bernard, AU - Ader,Robert, PY - 2004/11/27/pubmed PY - 2005/9/1/medline PY - 2004/11/27/entrez SP - 950 EP - 3 JF - Psychosomatic medicine JO - Psychosom Med VL - 66 IS - 6 N2 - OBJECTIVE: We examined the influence of psychological state (depression, negative affect, perceived stress) and social support on pre- and post-vaccination response to influenza vaccine. METHODS: Venous blood was drawn from 37 nursing home residents before and following injection of the trivalent influenza vaccine (comprised of the New Caledonia (NC), Hong Kong (HK), and Panama (Pan) strains of flu). The Geriatric Depression Scale, Perceived Stress Scale, Positive and Negative Affect Schedule, and Multidimensional Scale of Perceived Social Support were completed following the initial blood draw. RESULTS: Social support and perceived stress were correlated with pre-vaccine antibody responses to two of the three vaccine components (HK and NC). Social support was negatively correlated with both pre- and post-vaccine titers to Pan. Depression, positive affect, and negative affect were not related to vaccine response. CONCLUSIONS: Perceived stress and social support influence the rate of decline of antibody titers to previous exposures to some strains of influenza occurring either naturally or via deliberate vaccination. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/15564363/full_citation L2 - http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0033-3174&volume=66&issue=6&spage=950 ER -