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Indole-3-carbinol and prostate cancer.
J Nutr 2004; 134(12 Suppl):3493S-3498SJN

Abstract

Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. Our studies have shown that indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its in vivo dimeric product 3,3'-diindolylmethane (DIM) upregulate the expression of phase I and phase II enzymes, suggesting increased capacity for detoxification and inhibition of carcinogens. Studies from our laboratory and others have found that I3C can induce G1 cell-cycle arrest and apoptosis in prostate cancer cells. In addition, we found, by microarray gene expression profiling, that I3C and DIM regulate many genes that are important for the control of cell cycle, cell proliferation, signal transduction, and other cellular processes, suggesting the pleiotropic effects of I3C and DIM on prostate cancer cells. We recently found that I3C functions as an inhibitor of Akt and nuclear factor kappaB (NF-kappaB), which play important roles in cell survival and which are believed to be potential targets in cancer therapy. Studies have already shown that the inactivation of Akt and NF-kappaB is responsible for chemosensitization of chemoresistant cancer cells. Because there is no effective treatment strategy for hormone-dependent and, most importantly, hormone-independent and metastatic prostate cancer, our strategies to sensitize prostate cancer cells to a chemotherapeutic agent by I3C and DIM is a novel breakthrough that could be used for devising novel therapies for prostate cancer. In conclusion, the results from our laboratory and from others provide ample evidence for the benefit of I3C and DIM for the prevention and the treatment of prostate cancer.

Authors+Show Affiliations

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA. fsarkar@med.wayne.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15570059

Citation

Sarkar, Fazlul H., and Yiwei Li. "Indole-3-carbinol and Prostate Cancer." The Journal of Nutrition, vol. 134, no. 12 Suppl, 2004, 3493S-3498S.
Sarkar FH, Li Y. Indole-3-carbinol and prostate cancer. J Nutr. 2004;134(12 Suppl):3493S-3498S.
Sarkar, F. H., & Li, Y. (2004). Indole-3-carbinol and prostate cancer. The Journal of Nutrition, 134(12 Suppl), 3493S-3498S. doi:10.1093/jn/134.12.3493S.
Sarkar FH, Li Y. Indole-3-carbinol and Prostate Cancer. J Nutr. 2004;134(12 Suppl):3493S-3498S. PubMed PMID: 15570059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indole-3-carbinol and prostate cancer. AU - Sarkar,Fazlul H, AU - Li,Yiwei, PY - 2004/12/1/pubmed PY - 2005/1/14/medline PY - 2004/12/1/entrez SP - 3493S EP - 3498S JF - The Journal of nutrition JO - J. Nutr. VL - 134 IS - 12 Suppl N2 - Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. Our studies have shown that indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its in vivo dimeric product 3,3'-diindolylmethane (DIM) upregulate the expression of phase I and phase II enzymes, suggesting increased capacity for detoxification and inhibition of carcinogens. Studies from our laboratory and others have found that I3C can induce G1 cell-cycle arrest and apoptosis in prostate cancer cells. In addition, we found, by microarray gene expression profiling, that I3C and DIM regulate many genes that are important for the control of cell cycle, cell proliferation, signal transduction, and other cellular processes, suggesting the pleiotropic effects of I3C and DIM on prostate cancer cells. We recently found that I3C functions as an inhibitor of Akt and nuclear factor kappaB (NF-kappaB), which play important roles in cell survival and which are believed to be potential targets in cancer therapy. Studies have already shown that the inactivation of Akt and NF-kappaB is responsible for chemosensitization of chemoresistant cancer cells. Because there is no effective treatment strategy for hormone-dependent and, most importantly, hormone-independent and metastatic prostate cancer, our strategies to sensitize prostate cancer cells to a chemotherapeutic agent by I3C and DIM is a novel breakthrough that could be used for devising novel therapies for prostate cancer. In conclusion, the results from our laboratory and from others provide ample evidence for the benefit of I3C and DIM for the prevention and the treatment of prostate cancer. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/15570059/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/134.12.3493S DB - PRIME DP - Unbound Medicine ER -