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Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.
Diabetes Care 2005; 28(1):89-94DC

Abstract

OBJECTIVE

We evaluated frozen databases from two 52-week randomized placebo-controlled clinical diabetic neuropathy trials testing two doses of acetyl-L-carnitine (ALC): 500 and 1,000 mg/day t.i.d.

RESEARCH DESIGN AND METHODS

Intention-to-treat patients amounted to 1,257 or 93% of enrolled patients. Efficacy end points were sural nerve morphometry, nerve conduction velocities, vibration perception thresholds, clinical symptom scores, and a visual analogue scale for most bothersome symptom, most notably pain. The two studies were evaluated separately and combined.

RESULTS

Data showed significant improvements in sural nerve fiber numbers and regenerating nerve fiber clusters. Nerve conduction velocities and amplitudes did not improve, whereas vibration perception improved in both studies. Pain as the most bothersome symptom showed significant improvement in one study and in the combined cohort taking 1,000 mg ALC.

CONCLUSIONS

These studies demonstrate that ALC treatment is efficacious in alleviating symptoms, particularly pain, and improves nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy.

Authors+Show Affiliations

Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. asima@med.wayne.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

15616239

Citation

Sima, Anders A F., et al. "Acetyl-L-carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy: an Analysis of Two Randomized Placebo-controlled Trials." Diabetes Care, vol. 28, no. 1, 2005, pp. 89-94.
Sima AA, Calvani M, Mehra M, et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care. 2005;28(1):89-94.
Sima, A. A., Calvani, M., Mehra, M., & Amato, A. (2005). Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care, 28(1), pp. 89-94.
Sima AA, et al. Acetyl-L-carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy: an Analysis of Two Randomized Placebo-controlled Trials. Diabetes Care. 2005;28(1):89-94. PubMed PMID: 15616239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. AU - Sima,Anders A F, AU - Calvani,Menotti, AU - Mehra,Munish, AU - Amato,Antonino, AU - ,, PY - 2004/12/24/pubmed PY - 2005/5/25/medline PY - 2004/12/24/entrez SP - 89 EP - 94 JF - Diabetes care JO - Diabetes Care VL - 28 IS - 1 N2 - OBJECTIVE: We evaluated frozen databases from two 52-week randomized placebo-controlled clinical diabetic neuropathy trials testing two doses of acetyl-L-carnitine (ALC): 500 and 1,000 mg/day t.i.d. RESEARCH DESIGN AND METHODS: Intention-to-treat patients amounted to 1,257 or 93% of enrolled patients. Efficacy end points were sural nerve morphometry, nerve conduction velocities, vibration perception thresholds, clinical symptom scores, and a visual analogue scale for most bothersome symptom, most notably pain. The two studies were evaluated separately and combined. RESULTS: Data showed significant improvements in sural nerve fiber numbers and regenerating nerve fiber clusters. Nerve conduction velocities and amplitudes did not improve, whereas vibration perception improved in both studies. Pain as the most bothersome symptom showed significant improvement in one study and in the combined cohort taking 1,000 mg ALC. CONCLUSIONS: These studies demonstrate that ALC treatment is efficacious in alleviating symptoms, particularly pain, and improves nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/15616239/full_citation L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=15616239 DB - PRIME DP - Unbound Medicine ER -