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Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
J Neurol Neurosurg Psychiatry 1992; 55(3):181-4JN

Abstract

Few detailed clinico-pathological correlations of Parkinson's disease have been published. The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported. Seventy six had nigral Lewy bodies, and in all of these Lewy bodies were also found in the cerebral cortex. In 24 cases without Lewy bodies, diagnoses included progressive supranuclear palsy, multiple system atrophy, Alzheimer's disease, Alzheimer-type pathology, and basal ganglia vascular disease. The retrospective application of recommended diagnostic criteria improved the diagnostic accuracy to 82%. These observations call into question current concepts of Parkinson's disease as a single distinct morbid entity.

Authors+Show Affiliations

Parkinson's Disease Society Brain Bank, Institute of Neurology, London.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1564476

Citation

Hughes, A J., et al. "Accuracy of Clinical Diagnosis of Idiopathic Parkinson's Disease: a Clinico-pathological Study of 100 Cases." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 55, no. 3, 1992, pp. 181-4.
Hughes AJ, Daniel SE, Kilford L, et al. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181-4.
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992). Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. Journal of Neurology, Neurosurgery, and Psychiatry, 55(3), pp. 181-4.
Hughes AJ, et al. Accuracy of Clinical Diagnosis of Idiopathic Parkinson's Disease: a Clinico-pathological Study of 100 Cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181-4. PubMed PMID: 1564476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. AU - Hughes,A J, AU - Daniel,S E, AU - Kilford,L, AU - Lees,A J, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez SP - 181 EP - 4 JF - Journal of neurology, neurosurgery, and psychiatry JO - J. Neurol. Neurosurg. Psychiatry VL - 55 IS - 3 N2 - Few detailed clinico-pathological correlations of Parkinson's disease have been published. The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported. Seventy six had nigral Lewy bodies, and in all of these Lewy bodies were also found in the cerebral cortex. In 24 cases without Lewy bodies, diagnoses included progressive supranuclear palsy, multiple system atrophy, Alzheimer's disease, Alzheimer-type pathology, and basal ganglia vascular disease. The retrospective application of recommended diagnostic criteria improved the diagnostic accuracy to 82%. These observations call into question current concepts of Parkinson's disease as a single distinct morbid entity. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/1564476/full_citation L2 - http://jnnp.bmj.com/cgi/pmidlookup?view=long&pmid=1564476 DB - PRIME DP - Unbound Medicine ER -