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Reference values for serum silicon in adults.

Abstract

Silicon is an essential nutrient of fundamental importance to human biology. It has been shown that silicon is required for bone, cartilage, and connective tissue formation. However, the assessment of silicon concentration is difficult as reference values are lacking. The aim of the present study was to establish reference values for apparently healthy individuals. Silicon concentrations were determined in serum of 1325 healthy subjects 18-91 years of age using atomic absorption spectrometry. Medians for serum silicon concentrations showed a statistically significant age and sex dependency. In men 18-59 years of age the median was 9.5 micromol/L and decreased to 8.5 micromol/L at 60-74 years of age. In women there was an increase in the median from age 18-29 years (10.00 micromol/L) to 30-44 years (11.10 micromol/L) followed by a decrease in the age group of 45-59 years (9.23 micromol/L). In subjects aged over 74 years the median serum silicon values were 7.70 micromol/L for men and 8.00 micromol/L for women. The most important findings in this study are the decrease of silicon and the course of the silicon concentrations with age, especially in women. The present study is an important prerequisite for studies that aim to identify the health effects and medical implications of silicon.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Chemistry, University Hospital Freiburg, D-79106 Freiburg, Germany. bisse@med1.ukl.uni-freiburg.de

    , , , ,

    Source

    Analytical biochemistry 337:1 2005 Feb 01 pg 130-5

    MeSH

    Adolescent
    Adult
    Age Factors
    Aged
    Female
    Humans
    Male
    Middle Aged
    Reference Standards
    Reference Values
    Reproducibility of Results
    Sex Factors
    Silicon
    Spectrophotometry, Atomic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15649385

    Citation

    Bissé, Emmanuel, et al. "Reference Values for Serum Silicon in Adults." Analytical Biochemistry, vol. 337, no. 1, 2005, pp. 130-5.
    Bissé E, Epting T, Beil A, et al. Reference values for serum silicon in adults. Anal Biochem. 2005;337(1):130-5.
    Bissé, E., Epting, T., Beil, A., Lindinger, G., Lang, H., & Wieland, H. (2005). Reference values for serum silicon in adults. Analytical Biochemistry, 337(1), pp. 130-5.
    Bissé E, et al. Reference Values for Serum Silicon in Adults. Anal Biochem. 2005 Feb 1;337(1):130-5. PubMed PMID: 15649385.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reference values for serum silicon in adults. AU - Bissé,Emmanuel, AU - Epting,Thomas, AU - Beil,Annette, AU - Lindinger,Gabriele, AU - Lang,Helmut, AU - Wieland,Heinrich, PY - 2004/09/02/received PY - 2005/1/15/pubmed PY - 2005/7/13/medline PY - 2005/1/15/entrez SP - 130 EP - 5 JF - Analytical biochemistry JO - Anal. Biochem. VL - 337 IS - 1 N2 - Silicon is an essential nutrient of fundamental importance to human biology. It has been shown that silicon is required for bone, cartilage, and connective tissue formation. However, the assessment of silicon concentration is difficult as reference values are lacking. The aim of the present study was to establish reference values for apparently healthy individuals. Silicon concentrations were determined in serum of 1325 healthy subjects 18-91 years of age using atomic absorption spectrometry. Medians for serum silicon concentrations showed a statistically significant age and sex dependency. In men 18-59 years of age the median was 9.5 micromol/L and decreased to 8.5 micromol/L at 60-74 years of age. In women there was an increase in the median from age 18-29 years (10.00 micromol/L) to 30-44 years (11.10 micromol/L) followed by a decrease in the age group of 45-59 years (9.23 micromol/L). In subjects aged over 74 years the median serum silicon values were 7.70 micromol/L for men and 8.00 micromol/L for women. The most important findings in this study are the decrease of silicon and the course of the silicon concentrations with age, especially in women. The present study is an important prerequisite for studies that aim to identify the health effects and medical implications of silicon. SN - 0003-2697 UR - https://www.unboundmedicine.com/medline/citation/15649385/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2697(04)00853-X DB - PRIME DP - Unbound Medicine ER -