Tags

Type your tag names separated by a space and hit enter

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Cell 2005; 120(2):261-73Cell

Abstract

The PGC-1 family of coactivators stimulates the activity of certain transcription factors and nuclear receptors. Transcription factors in the sterol responsive element binding protein (SREBP) family are key regulators of the lipogenic genes in the liver. We show here that high-fat feeding, which induces hyperlipidemia and atherogenesis, stimulates the expression of both PGC-1beta and SREBP1c and 1a in liver. PGC-1beta coactivates the SREBP transcription factor family and stimulates lipogenic gene expression. Further, PGC-1beta is required for SREBP-mediated lipogenic gene expression. However, unlike SREBP itself, PGC-1beta reduces fat accumulation in the liver while greatly increasing circulating triglycerides and cholesterol in VLDL particles. The stimulation of lipoprotein transport upon PGC-1beta expression is likely due to the simultaneous coactivation of the liver X receptor, LXRalpha, a nuclear hormone receptor with known roles in hepatic lipid transport. These data suggest a mechanism through which dietary saturated fats can stimulate hyperlipidemia and atherogenesis.

Authors+Show Affiliations

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15680331

Citation

Lin, Jiandie, et al. "Hyperlipidemic Effects of Dietary Saturated Fats Mediated Through PGC-1beta Coactivation of SREBP." Cell, vol. 120, no. 2, 2005, pp. 261-73.
Lin J, Yang R, Tarr PT, et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 2005;120(2):261-73.
Lin, J., Yang, R., Tarr, P. T., Wu, P. H., Handschin, C., Li, S., ... Spiegelman, B. M. (2005). Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell, 120(2), pp. 261-73.
Lin J, et al. Hyperlipidemic Effects of Dietary Saturated Fats Mediated Through PGC-1beta Coactivation of SREBP. Cell. 2005 Jan 28;120(2):261-73. PubMed PMID: 15680331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. AU - Lin,Jiandie, AU - Yang,Ruojing, AU - Tarr,Paul T, AU - Wu,Pei-Hsuan, AU - Handschin,Christoph, AU - Li,Siming, AU - Yang,Wenli, AU - Pei,Liming, AU - Uldry,Marc, AU - Tontonoz,Peter, AU - Newgard,Christopher B, AU - Spiegelman,Bruce M, PY - 2004/06/13/received PY - 2004/11/15/revised PY - 2004/11/22/accepted PY - 2005/2/1/pubmed PY - 2005/3/10/medline PY - 2005/2/1/entrez SP - 261 EP - 73 JF - Cell JO - Cell VL - 120 IS - 2 N2 - The PGC-1 family of coactivators stimulates the activity of certain transcription factors and nuclear receptors. Transcription factors in the sterol responsive element binding protein (SREBP) family are key regulators of the lipogenic genes in the liver. We show here that high-fat feeding, which induces hyperlipidemia and atherogenesis, stimulates the expression of both PGC-1beta and SREBP1c and 1a in liver. PGC-1beta coactivates the SREBP transcription factor family and stimulates lipogenic gene expression. Further, PGC-1beta is required for SREBP-mediated lipogenic gene expression. However, unlike SREBP itself, PGC-1beta reduces fat accumulation in the liver while greatly increasing circulating triglycerides and cholesterol in VLDL particles. The stimulation of lipoprotein transport upon PGC-1beta expression is likely due to the simultaneous coactivation of the liver X receptor, LXRalpha, a nuclear hormone receptor with known roles in hepatic lipid transport. These data suggest a mechanism through which dietary saturated fats can stimulate hyperlipidemia and atherogenesis. SN - 0092-8674 UR - https://www.unboundmedicine.com/medline/citation/15680331/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S009286740401147X DB - PRIME DP - Unbound Medicine ER -