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Vitamin C deficiency in cancer patients.
Palliat Med 2005; 19(1):17-20PM

Abstract

PURPOSE

To assess the prevalence of vitamin C deficiency within a group of hospice patients. To assess the relationship between plasma vitamin C, dietary intake and subsequent survival.

METHODS

Patients with advanced cancer were recruited from a large hospice. Data were collected on demographic details, physical functioning and smoking history. An estimate was obtained of the number of weekly dietary portions consumed equivalent to 40 mg of vitamin C, the recommended daily intake. Plasma vitamin C was measured by a single blood sample. The study had local ethical approval.

RESULTS

Fifty patients were recruited (mean age 65.2 years, 28 female). Plasma vitamin C deficiency was found in 15 (30%). Dietary intake of vitamin C was correlated to plasma vitamin C (r=0.518, P<0.0001). Low dietary intake, low albumin, high platelet count, high CRP level and shorter survival were all significantly associated with low plasma vitamin C concentrations (<11 micromol/L). There was no correlation between plasma vitamin C, smoking history or physical functioning.

CONCLUSION

Vitamin C deficiency is common in patients with advanced cancer and the most important factors determining plasma levels are dietary intake and markers of the inflammatory response. Patients with low plasma concentrations of vitamin C have a shorter survival.

Authors+Show Affiliations

St Gemma's Hospice, Harrogate Road, Leeds LS17 6QD, UK. catrionamayland@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15690864

Citation

Mayland, Catriona R., et al. "Vitamin C Deficiency in Cancer Patients." Palliative Medicine, vol. 19, no. 1, 2005, pp. 17-20.
Mayland CR, Bennett MI, Allan K. Vitamin C deficiency in cancer patients. Palliat Med. 2005;19(1):17-20.
Mayland, C. R., Bennett, M. I., & Allan, K. (2005). Vitamin C deficiency in cancer patients. Palliative Medicine, 19(1), pp. 17-20.
Mayland CR, Bennett MI, Allan K. Vitamin C Deficiency in Cancer Patients. Palliat Med. 2005;19(1):17-20. PubMed PMID: 15690864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin C deficiency in cancer patients. AU - Mayland,Catriona R, AU - Bennett,Michael I, AU - Allan,Keith, PY - 2005/2/5/pubmed PY - 2005/6/17/medline PY - 2005/2/5/entrez SP - 17 EP - 20 JF - Palliative medicine JO - Palliat Med VL - 19 IS - 1 N2 - PURPOSE: To assess the prevalence of vitamin C deficiency within a group of hospice patients. To assess the relationship between plasma vitamin C, dietary intake and subsequent survival. METHODS: Patients with advanced cancer were recruited from a large hospice. Data were collected on demographic details, physical functioning and smoking history. An estimate was obtained of the number of weekly dietary portions consumed equivalent to 40 mg of vitamin C, the recommended daily intake. Plasma vitamin C was measured by a single blood sample. The study had local ethical approval. RESULTS: Fifty patients were recruited (mean age 65.2 years, 28 female). Plasma vitamin C deficiency was found in 15 (30%). Dietary intake of vitamin C was correlated to plasma vitamin C (r=0.518, P<0.0001). Low dietary intake, low albumin, high platelet count, high CRP level and shorter survival were all significantly associated with low plasma vitamin C concentrations (<11 micromol/L). There was no correlation between plasma vitamin C, smoking history or physical functioning. CONCLUSION: Vitamin C deficiency is common in patients with advanced cancer and the most important factors determining plasma levels are dietary intake and markers of the inflammatory response. Patients with low plasma concentrations of vitamin C have a shorter survival. SN - 0269-2163 UR - https://www.unboundmedicine.com/medline/citation/15690864/full_citation L2 - http://journals.sagepub.com/doi/full/10.1191/0269216305pm970oa?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -