Type your tag names separated by a space and hit enter

Narrative review: celiac disease: understanding a complex autoimmune disorder.

Abstract

Celiac disease is a common autoimmune disorder that has genetic, environmental, and immunologic components. It is characterized by an immune response to ingested wheat gluten and related proteins of rye and barley that leads to inflammation, villous atrophy, and crypt hyperplasia in the intestine. The disease is closely associated with genes that code for human leukocyte antigens DQ2 and DQ8. Transglutaminase 2 appears to be an important component of the disease, both as a deamidating enzyme that can enhance the immunostimulatory effect of gluten and as a target autoantigen in the immune response. Sensitive and specific serologic tests, including those for anti-transglutaminase antibody, are facilitating fast and noninvasive screening for celiac disease. Thus, they are contributing to a more accurate estimate of the prevalence of the disease and its association with other disorders. Celiac disease is associated with increased rates of anemia, osteoporosis, cancer, neurologic deficits, and additional autoimmune disorders. A gluten-free diet is the mainstay of safe and effective treatment of celiac disease, although its effect on some of the extraintestinal manifestations of the disease remains to be determined.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology and Neuroscience, Cornell University, New York, New York 10021, USA. ara2004@med.cornell.edu

    Source

    Annals of internal medicine 142:4 2005 Feb 15 pg 289-98

    MeSH

    Autoantibodies
    Autoimmune Diseases
    Biomarkers
    Celiac Disease
    Humans

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15710962

    Citation

    Alaedini, Armin, and Peter H R. Green. "Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder." Annals of Internal Medicine, vol. 142, no. 4, 2005, pp. 289-98.
    Alaedini A, Green PH. Narrative review: celiac disease: understanding a complex autoimmune disorder. Ann Intern Med. 2005;142(4):289-98.
    Alaedini, A., & Green, P. H. (2005). Narrative review: celiac disease: understanding a complex autoimmune disorder. Annals of Internal Medicine, 142(4), pp. 289-98.
    Alaedini A, Green PH. Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder. Ann Intern Med. 2005 Feb 15;142(4):289-98. PubMed PMID: 15710962.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Narrative review: celiac disease: understanding a complex autoimmune disorder. AU - Alaedini,Armin, AU - Green,Peter H R, PY - 2005/2/16/pubmed PY - 2005/2/24/medline PY - 2005/2/16/entrez SP - 289 EP - 98 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 142 IS - 4 N2 - Celiac disease is a common autoimmune disorder that has genetic, environmental, and immunologic components. It is characterized by an immune response to ingested wheat gluten and related proteins of rye and barley that leads to inflammation, villous atrophy, and crypt hyperplasia in the intestine. The disease is closely associated with genes that code for human leukocyte antigens DQ2 and DQ8. Transglutaminase 2 appears to be an important component of the disease, both as a deamidating enzyme that can enhance the immunostimulatory effect of gluten and as a target autoantigen in the immune response. Sensitive and specific serologic tests, including those for anti-transglutaminase antibody, are facilitating fast and noninvasive screening for celiac disease. Thus, they are contributing to a more accurate estimate of the prevalence of the disease and its association with other disorders. Celiac disease is associated with increased rates of anemia, osteoporosis, cancer, neurologic deficits, and additional autoimmune disorders. A gluten-free diet is the mainstay of safe and effective treatment of celiac disease, although its effect on some of the extraintestinal manifestations of the disease remains to be determined. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/15710962/full_citation L2 - https://www.annals.org/article.aspx?volume=142&issue=4&page=289 DB - PRIME DP - Unbound Medicine ER -