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Narrative review: celiac disease: understanding a complex autoimmune disorder.
Ann Intern Med 2005; 142(4):289-98AIM

Abstract

Celiac disease is a common autoimmune disorder that has genetic, environmental, and immunologic components. It is characterized by an immune response to ingested wheat gluten and related proteins of rye and barley that leads to inflammation, villous atrophy, and crypt hyperplasia in the intestine. The disease is closely associated with genes that code for human leukocyte antigens DQ2 and DQ8. Transglutaminase 2 appears to be an important component of the disease, both as a deamidating enzyme that can enhance the immunostimulatory effect of gluten and as a target autoantigen in the immune response. Sensitive and specific serologic tests, including those for anti-transglutaminase antibody, are facilitating fast and noninvasive screening for celiac disease. Thus, they are contributing to a more accurate estimate of the prevalence of the disease and its association with other disorders. Celiac disease is associated with increased rates of anemia, osteoporosis, cancer, neurologic deficits, and additional autoimmune disorders. A gluten-free diet is the mainstay of safe and effective treatment of celiac disease, although its effect on some of the extraintestinal manifestations of the disease remains to be determined.

Authors+Show Affiliations

Department of Neurology and Neuroscience, Cornell University, New York, New York 10021, USA. ara2004@med.cornell.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15710962

Citation

Alaedini, Armin, and Peter H R. Green. "Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder." Annals of Internal Medicine, vol. 142, no. 4, 2005, pp. 289-98.
Alaedini A, Green PH. Narrative review: celiac disease: understanding a complex autoimmune disorder. Ann Intern Med. 2005;142(4):289-98.
Alaedini, A., & Green, P. H. (2005). Narrative review: celiac disease: understanding a complex autoimmune disorder. Annals of Internal Medicine, 142(4), pp. 289-98.
Alaedini A, Green PH. Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder. Ann Intern Med. 2005 Feb 15;142(4):289-98. PubMed PMID: 15710962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Narrative review: celiac disease: understanding a complex autoimmune disorder. AU - Alaedini,Armin, AU - Green,Peter H R, PY - 2005/2/16/pubmed PY - 2005/2/24/medline PY - 2005/2/16/entrez SP - 289 EP - 98 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 142 IS - 4 N2 - Celiac disease is a common autoimmune disorder that has genetic, environmental, and immunologic components. It is characterized by an immune response to ingested wheat gluten and related proteins of rye and barley that leads to inflammation, villous atrophy, and crypt hyperplasia in the intestine. The disease is closely associated with genes that code for human leukocyte antigens DQ2 and DQ8. Transglutaminase 2 appears to be an important component of the disease, both as a deamidating enzyme that can enhance the immunostimulatory effect of gluten and as a target autoantigen in the immune response. Sensitive and specific serologic tests, including those for anti-transglutaminase antibody, are facilitating fast and noninvasive screening for celiac disease. Thus, they are contributing to a more accurate estimate of the prevalence of the disease and its association with other disorders. Celiac disease is associated with increased rates of anemia, osteoporosis, cancer, neurologic deficits, and additional autoimmune disorders. A gluten-free diet is the mainstay of safe and effective treatment of celiac disease, although its effect on some of the extraintestinal manifestations of the disease remains to be determined. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/15710962/full_citation L2 - https://www.annals.org/article.aspx?volume=142&issue=4&page=289 DB - PRIME DP - Unbound Medicine ER -