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CSF iron, ferritin and transferrin levels in restless legs syndrome.
J Sleep Res 2005; 14(1):43-7JS

Abstract

The aim of this study is evaluating iron, ferritin, and transferrin in both serum and CSF in patients of restless legs syndrome (RLS), based on the hypothesis that iron deficiency in the central nervous system (CNS) causes the symptoms as a result of the dysfunction of dopaminergic systems. These parameters, polysomnographic sleep measures, and subjective evaluation of the sleep quality were compared in 10 patients of idiopathic RLS (RLS group) and 10 age-matched patients of psychophysiological insomnia without RLS symptoms (non-RLS group). With sleep patterns, sleep latency was longer and sleep efficiency was lower in the RLS group than those in the non-RLS group. Periodic leg movement index in the RLS group was higher than that of the non-RLS group. With serum examination, there were no significant differences for the iron, ferritin, and transferrin values between the both groups. With CSF examination, the iron and ferritin values were lower and the transferrin values were higher in the RLS group than those in the non-RLS group. There was positive correlation between the serum and CSF ferritin levels in the both groups, but the slope of the regression lines for the RLS group was lower than that for the non-RLS group. These results indicate low brain iron concentration caused by the dysfunction of iron transportation from serum to CNS in patients with idiopathic RLS.

Authors+Show Affiliations

Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan. psychi2@shimane-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15743333

Citation

Mizuno, Soichi, et al. "CSF Iron, Ferritin and Transferrin Levels in Restless Legs Syndrome." Journal of Sleep Research, vol. 14, no. 1, 2005, pp. 43-7.
Mizuno S, Mihara T, Miyaoka T, et al. CSF iron, ferritin and transferrin levels in restless legs syndrome. J Sleep Res. 2005;14(1):43-7.
Mizuno, S., Mihara, T., Miyaoka, T., Inagaki, T., & Horiguchi, J. (2005). CSF iron, ferritin and transferrin levels in restless legs syndrome. Journal of Sleep Research, 14(1), pp. 43-7.
Mizuno S, et al. CSF Iron, Ferritin and Transferrin Levels in Restless Legs Syndrome. J Sleep Res. 2005;14(1):43-7. PubMed PMID: 15743333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CSF iron, ferritin and transferrin levels in restless legs syndrome. AU - Mizuno,Soichi, AU - Mihara,Takumi, AU - Miyaoka,Tsuyoshi, AU - Inagaki,Takuzi, AU - Horiguchi,Jun, PY - 2005/3/4/pubmed PY - 2005/7/1/medline PY - 2005/3/4/entrez SP - 43 EP - 7 JF - Journal of sleep research JO - J Sleep Res VL - 14 IS - 1 N2 - The aim of this study is evaluating iron, ferritin, and transferrin in both serum and CSF in patients of restless legs syndrome (RLS), based on the hypothesis that iron deficiency in the central nervous system (CNS) causes the symptoms as a result of the dysfunction of dopaminergic systems. These parameters, polysomnographic sleep measures, and subjective evaluation of the sleep quality were compared in 10 patients of idiopathic RLS (RLS group) and 10 age-matched patients of psychophysiological insomnia without RLS symptoms (non-RLS group). With sleep patterns, sleep latency was longer and sleep efficiency was lower in the RLS group than those in the non-RLS group. Periodic leg movement index in the RLS group was higher than that of the non-RLS group. With serum examination, there were no significant differences for the iron, ferritin, and transferrin values between the both groups. With CSF examination, the iron and ferritin values were lower and the transferrin values were higher in the RLS group than those in the non-RLS group. There was positive correlation between the serum and CSF ferritin levels in the both groups, but the slope of the regression lines for the RLS group was lower than that for the non-RLS group. These results indicate low brain iron concentration caused by the dysfunction of iron transportation from serum to CNS in patients with idiopathic RLS. SN - 0962-1105 UR - https://www.unboundmedicine.com/medline/citation/15743333/full_citation L2 - https://doi.org/10.1111/j.1365-2869.2004.00403.x DB - PRIME DP - Unbound Medicine ER -