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Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring.
Am J Psychiatry 2005; 162(4):767-73AJ

Abstract

OBJECTIVE

The authors examined the relationship between maternal antibody to toxoplasmosis and the risk of schizophrenia and other schizophrenia spectrum disorders in offspring. Toxoplasmosis is known to adversely affect fetal brain development.

METHOD

In a nested case-control design of a large birth cohort born between 1959 and 1967, the authors conducted serological assays for Toxoplasma antibody on maternal serum specimens from pregnancies giving rise to 63 cases of schizophrenia and other schizophrenia spectrum disorders and 123 matched comparison subjects. Toxoplasma immunoglobulin (Ig)G antibody was quantified by using the Sabin-Feldman dye test. The Ig titers were classified into three groups: negative (<1:16) (reference), moderate (1:16-1:64), and high (> or =1:128).

RESULTS

The adjusted odds ratio of schizophrenia/schizophrenia spectrum disorders for subjects with high maternal Toxoplasma IgG antibody titers was 2.61 (95% confidence interval=1.00-6.82). There was no association between moderate Toxoplasma Ig antibody titers and the risk of schizophrenia/spectrum disorders.

CONCLUSIONS

These findings suggest that maternal exposure to toxoplasmosis may be a risk factor for schizophrenia. The findings may be explained by reactivated infection or an effect of the antibody on the developing fetus. Given that toxoplasmosis is a preventable infection, the findings, if replicated, may have implications for reducing the incidence of schizophrenia.

Authors+Show Affiliations

New York State Psychiatric Institute, 1051 Riverside Dr., Unit 23, New York, NY 10032, USA. asb11@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15800151

Citation

Brown, Alan S., et al. "Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring." The American Journal of Psychiatry, vol. 162, no. 4, 2005, pp. 767-73.
Brown AS, Schaefer CA, Quesenberry CP, et al. Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry. 2005;162(4):767-73.
Brown, A. S., Schaefer, C. A., Quesenberry, C. P., Liu, L., Babulas, V. P., & Susser, E. S. (2005). Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. The American Journal of Psychiatry, 162(4), pp. 767-73.
Brown AS, et al. Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring. Am J Psychiatry. 2005;162(4):767-73. PubMed PMID: 15800151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. AU - Brown,Alan S, AU - Schaefer,Catherine A, AU - Quesenberry,Charles P,Jr AU - Liu,Liyan, AU - Babulas,Vicki P, AU - Susser,Ezra S, PY - 2005/4/1/pubmed PY - 2005/5/18/medline PY - 2005/4/1/entrez SP - 767 EP - 73 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 162 IS - 4 N2 - OBJECTIVE: The authors examined the relationship between maternal antibody to toxoplasmosis and the risk of schizophrenia and other schizophrenia spectrum disorders in offspring. Toxoplasmosis is known to adversely affect fetal brain development. METHOD: In a nested case-control design of a large birth cohort born between 1959 and 1967, the authors conducted serological assays for Toxoplasma antibody on maternal serum specimens from pregnancies giving rise to 63 cases of schizophrenia and other schizophrenia spectrum disorders and 123 matched comparison subjects. Toxoplasma immunoglobulin (Ig)G antibody was quantified by using the Sabin-Feldman dye test. The Ig titers were classified into three groups: negative (<1:16) (reference), moderate (1:16-1:64), and high (> or =1:128). RESULTS: The adjusted odds ratio of schizophrenia/schizophrenia spectrum disorders for subjects with high maternal Toxoplasma IgG antibody titers was 2.61 (95% confidence interval=1.00-6.82). There was no association between moderate Toxoplasma Ig antibody titers and the risk of schizophrenia/spectrum disorders. CONCLUSIONS: These findings suggest that maternal exposure to toxoplasmosis may be a risk factor for schizophrenia. The findings may be explained by reactivated infection or an effect of the antibody on the developing fetus. Given that toxoplasmosis is a preventable infection, the findings, if replicated, may have implications for reducing the incidence of schizophrenia. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/15800151/full_citation L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.162.4.767?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -