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Modulation of immune cell function by polyunsaturated fatty acids.

Abstract

The n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential dietary constituents. They are important as a source of energy, as structural components of cell membranes, and as signalling molecules. They have been demonstrated to be potent modulators of the immune response, and research has endeavoured to optimise the ratio of n-3 to n-6 PUFAs in the lipid component of total parenteral nutrition (TPN) to optimise their beneficial effects in the clinical setting. Critically ill neonates on TPN have an increased incidence of sepsis, and additional studies have determined that lipid emulsions depress various elements of cellular immune responses in monocytes, lymphocytes, and neutrophils. It has been proposed that PUFAs may mediate their manifold effects through the modification of eicosanoid production and by directly or indirectly modifying intracellular signal transduction pathways, including the alteration of gene transcription, in various tissues. They are susceptible to lipid peroxidation, and there is evidence that the products of this process may result in cell death by apoptosis, a nonphlogistic homeostatic process of cell deletion. PUFAs have been shown to induce apoptosis in primary lymphocytes, colonic mucosal cells, and various cell lines. Additionally, our laboratory has shown them to be potent inducers of apoptosis in neonatal monocytes. This may represent a novel mechanism whereby PUFAs may modify the immune response.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Children's Research Centre, University College Dublin, Our Lady's Hospital for Sick Children, Crumlin, Dublin, 12, Ireland.

    ,

    Source

    Pediatric surgery international 21:5 2005 May pg 335-40

    MeSH

    Animals
    Animals, Newborn
    Apoptosis
    Cell Survival
    Dose-Response Relationship, Immunologic
    Fatty Acids, Unsaturated
    Humans
    Immune System
    Infant, Newborn
    Nutritional Support

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    15834730

    Citation

    Sweeney, Brian, et al. "Modulation of Immune Cell Function By Polyunsaturated Fatty Acids." Pediatric Surgery International, vol. 21, no. 5, 2005, pp. 335-40.
    Sweeney B, Puri P, Reen DJ. Modulation of immune cell function by polyunsaturated fatty acids. Pediatr Surg Int. 2005;21(5):335-40.
    Sweeney, B., Puri, P., & Reen, D. J. (2005). Modulation of immune cell function by polyunsaturated fatty acids. Pediatric Surgery International, 21(5), pp. 335-40.
    Sweeney B, Puri P, Reen DJ. Modulation of Immune Cell Function By Polyunsaturated Fatty Acids. Pediatr Surg Int. 2005;21(5):335-40. PubMed PMID: 15834730.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Modulation of immune cell function by polyunsaturated fatty acids. AU - Sweeney,Brian, AU - Puri,Prem, AU - Reen,Denis J, Y1 - 2005/04/16/ PY - 2005/01/25/accepted PY - 2005/4/19/pubmed PY - 2005/9/9/medline PY - 2005/4/19/entrez SP - 335 EP - 40 JF - Pediatric surgery international JO - Pediatr. Surg. Int. VL - 21 IS - 5 N2 - The n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential dietary constituents. They are important as a source of energy, as structural components of cell membranes, and as signalling molecules. They have been demonstrated to be potent modulators of the immune response, and research has endeavoured to optimise the ratio of n-3 to n-6 PUFAs in the lipid component of total parenteral nutrition (TPN) to optimise their beneficial effects in the clinical setting. Critically ill neonates on TPN have an increased incidence of sepsis, and additional studies have determined that lipid emulsions depress various elements of cellular immune responses in monocytes, lymphocytes, and neutrophils. It has been proposed that PUFAs may mediate their manifold effects through the modification of eicosanoid production and by directly or indirectly modifying intracellular signal transduction pathways, including the alteration of gene transcription, in various tissues. They are susceptible to lipid peroxidation, and there is evidence that the products of this process may result in cell death by apoptosis, a nonphlogistic homeostatic process of cell deletion. PUFAs have been shown to induce apoptosis in primary lymphocytes, colonic mucosal cells, and various cell lines. Additionally, our laboratory has shown them to be potent inducers of apoptosis in neonatal monocytes. This may represent a novel mechanism whereby PUFAs may modify the immune response. SN - 0179-0358 UR - https://www.unboundmedicine.com/medline/citation/15834730/full_citation L2 - https://dx.doi.org/10.1007/s00383-005-1385-x DB - PRIME DP - Unbound Medicine ER -