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Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study.

Abstract

OBJECTIVE

To evaluate the occurrence of stroke/TIA symptoms and ischemic stroke events among those with a lifetime history of migraine or other headaches with some migraine features in a biracial cohort of older adults.

METHODS

Participants were 12,750 African-American and white men and women from the Atherosclerosis Risk in Communities Study (1993 to 1995). The participants were queried about their lifetime headache history and characterized using modified International Headache Society diagnostic criteria. Stroke/TIA symptoms were classified using a computerized diagnostic algorithm, and ischemic stroke events were identified and validated using medical records. Multivariate logistic regression was used to assess the relationship between headache types and stroke/TIA symptoms and ischemic stroke events.

RESULTS

Migraine with aura was strongly associated with stroke symptoms (odds ratio [OR] 5.46, 95% CI: 3.64 to 8.18), TIA symptoms (OR 4.28, 95% CI: 3.02 to 6.08), and verified ischemic stroke events (OR 2.81, 95% CI: 1.60 to 4.92). Similarly, other headaches with aura were significantly associated with stroke symptoms (OR 3.68, 95% CI: 2.26 to 5.99) and TIA symptoms (OR 4.53, 95% CI: 3.08 to 6.67). In contrast, the associations for migraine without aura and other headaches without aura were not as consistent or robust.

CONCLUSIONS

Migraines and other headaches, particularly those accompanied by aura, were associated with an increased occurrence of stroke/TIA symptoms and ischemic stroke events.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.

    , , , , ,

    Source

    Neurology 64:9 2005 May 10 pg 1573-7

    MeSH

    African Continental Ancestry Group
    Age Factors
    Algorithms
    Cerebrovascular Disorders
    Cohort Studies
    Comorbidity
    Cross-Sectional Studies
    Data Collection
    Diagnosis, Differential
    European Continental Ancestry Group
    Female
    Health Surveys
    Humans
    Intracranial Arteriosclerosis
    Ischemic Attack, Transient
    Male
    Middle Aged
    Migraine with Aura
    Sex Factors
    Stroke
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15883318

    Citation

    Stang, P E., et al. "Headache, Cerebrovascular Symptoms, and Stroke: the Atherosclerosis Risk in Communities Study." Neurology, vol. 64, no. 9, 2005, pp. 1573-7.
    Stang PE, Carson AP, Rose KM, et al. Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study. Neurology. 2005;64(9):1573-7.
    Stang, P. E., Carson, A. P., Rose, K. M., Mo, J., Ephross, S. A., Shahar, E., & Szklo, M. (2005). Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study. Neurology, 64(9), pp. 1573-7.
    Stang PE, et al. Headache, Cerebrovascular Symptoms, and Stroke: the Atherosclerosis Risk in Communities Study. Neurology. 2005 May 10;64(9):1573-7. PubMed PMID: 15883318.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study. AU - Stang,P E, AU - Carson,A P, AU - Rose,K M, AU - Mo,J, AU - Ephross,S A, AU - Shahar,E, AU - Szklo,M, PY - 2005/5/11/pubmed PY - 2006/1/7/medline PY - 2005/5/11/entrez SP - 1573 EP - 7 JF - Neurology JO - Neurology VL - 64 IS - 9 N2 - OBJECTIVE: To evaluate the occurrence of stroke/TIA symptoms and ischemic stroke events among those with a lifetime history of migraine or other headaches with some migraine features in a biracial cohort of older adults. METHODS: Participants were 12,750 African-American and white men and women from the Atherosclerosis Risk in Communities Study (1993 to 1995). The participants were queried about their lifetime headache history and characterized using modified International Headache Society diagnostic criteria. Stroke/TIA symptoms were classified using a computerized diagnostic algorithm, and ischemic stroke events were identified and validated using medical records. Multivariate logistic regression was used to assess the relationship between headache types and stroke/TIA symptoms and ischemic stroke events. RESULTS: Migraine with aura was strongly associated with stroke symptoms (odds ratio [OR] 5.46, 95% CI: 3.64 to 8.18), TIA symptoms (OR 4.28, 95% CI: 3.02 to 6.08), and verified ischemic stroke events (OR 2.81, 95% CI: 1.60 to 4.92). Similarly, other headaches with aura were significantly associated with stroke symptoms (OR 3.68, 95% CI: 2.26 to 5.99) and TIA symptoms (OR 4.53, 95% CI: 3.08 to 6.67). In contrast, the associations for migraine without aura and other headaches without aura were not as consistent or robust. CONCLUSIONS: Migraines and other headaches, particularly those accompanied by aura, were associated with an increased occurrence of stroke/TIA symptoms and ischemic stroke events. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15883318/full_citation L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=15883318 DB - PRIME DP - Unbound Medicine ER -