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Dietary magnesium and C-reactive protein levels.
J Am Coll Nutr 2005; 24(3):166-71JA

Abstract

OBJECTIVE

Current dietary guidelines recommend adequate intake of magnesium (310-420 mg daily) in order to maintain health and lower the risk of cardiovascular disease. Recent evidence from animal and clinical studies suggests that magnesium may be associated with inflammatory processes. The objective of this study was to determine whether dietary magnesium consumption is associated with C-reactive protein (CRP), a marker of inflammation, in a nationally representative sample.

METHODS

Analysis of adult (> or =17 years) participants in a cross-sectional nationally representative survey (National Health and Nutrition Examination Survey 1999-2000 [NHANES]) who were not taking magnesium or magnesium-containing supplements. The primary outcome measure was high sensitivity CRP (elevated > or =3.0 mg/L).

RESULTS

Among US adults, 68% consumed less than the recommended daily allowance (RDA) of magnesium, and 19% consumed less than 50% of the RDA. After controlling for demographic and cardiovascular risk factors, adults who consumed <RDA of magnesium were 1.48-1.75 times more likely to have elevated CRP than adults who consumed > or =RDA (Odds Ratio [OR] for intake <50% RDA = 1.75, 95% Confidence Interval [CI] 1.08-2.87). Adults who were over age 40 with a BMI >25 and who consumed <50% RDA for magnesium were 2.24 times more likely to have elevated CRP (95% CI 1.13-4.46) than adults > or =RDA.

CONCLUSIONS

Most Americans consume magnesium at levels below the RDA. Individuals with intakes below the RDA are more likely to have elevated CRP, which may contribute to cardiovascular disease risk.

Authors+Show Affiliations

Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, PO Box 250192, Charleston, SC 29425, USA. kingde@musc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15930481

Citation

King, Dana E., et al. "Dietary Magnesium and C-reactive Protein Levels." Journal of the American College of Nutrition, vol. 24, no. 3, 2005, pp. 166-71.
King DE, Mainous AG, Geesey ME, et al. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr. 2005;24(3):166-71.
King, D. E., Mainous, A. G., Geesey, M. E., & Woolson, R. F. (2005). Dietary magnesium and C-reactive protein levels. Journal of the American College of Nutrition, 24(3), pp. 166-71.
King DE, et al. Dietary Magnesium and C-reactive Protein Levels. J Am Coll Nutr. 2005;24(3):166-71. PubMed PMID: 15930481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary magnesium and C-reactive protein levels. AU - King,Dana E, AU - Mainous,Arch G,3rd AU - Geesey,Mark E, AU - Woolson,Robert F, PY - 2005/6/3/pubmed PY - 2005/12/13/medline PY - 2005/6/3/entrez SP - 166 EP - 71 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 24 IS - 3 N2 - OBJECTIVE: Current dietary guidelines recommend adequate intake of magnesium (310-420 mg daily) in order to maintain health and lower the risk of cardiovascular disease. Recent evidence from animal and clinical studies suggests that magnesium may be associated with inflammatory processes. The objective of this study was to determine whether dietary magnesium consumption is associated with C-reactive protein (CRP), a marker of inflammation, in a nationally representative sample. METHODS: Analysis of adult (> or =17 years) participants in a cross-sectional nationally representative survey (National Health and Nutrition Examination Survey 1999-2000 [NHANES]) who were not taking magnesium or magnesium-containing supplements. The primary outcome measure was high sensitivity CRP (elevated > or =3.0 mg/L). RESULTS: Among US adults, 68% consumed less than the recommended daily allowance (RDA) of magnesium, and 19% consumed less than 50% of the RDA. After controlling for demographic and cardiovascular risk factors, adults who consumed <RDA of magnesium were 1.48-1.75 times more likely to have elevated CRP than adults who consumed > or =RDA (Odds Ratio [OR] for intake <50% RDA = 1.75, 95% Confidence Interval [CI] 1.08-2.87). Adults who were over age 40 with a BMI >25 and who consumed <50% RDA for magnesium were 2.24 times more likely to have elevated CRP (95% CI 1.13-4.46) than adults > or =RDA. CONCLUSIONS: Most Americans consume magnesium at levels below the RDA. Individuals with intakes below the RDA are more likely to have elevated CRP, which may contribute to cardiovascular disease risk. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/15930481/full_citation L2 - https://www.pharmgkb.org/pmid/15930481 DB - PRIME DP - Unbound Medicine ER -