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Breastfeeding and risk of schizophrenia in the Copenhagen Perinatal Cohort.

Abstract

OBJECTIVE

The aim was to study whether early weaning from breastfeeding may be associated with increased risk of schizophrenia.

METHOD

The current sample comprises 6841 individuals from the Copenhagen Perinatal Cohort of whom 1671 (24%) had been breastfed for 2 weeks or less (early weaning) and 5170 (76%) had been breastfed longer. Maternal schizophrenia, parental social status, single mother status and gender were included as covariates in a multiple regression analysis of the effect of early weaning on the risk of hospitalization with schizophrenia.

RESULTS

The sample comprised 93 cases of schizophrenia (1.4%). Maternal schizophrenia was the strongest risk factor and a significant association between single mother status and elevated offspring risk of schizophrenia was also observed. Early weaning was significantly related to later schizophrenia in both unadjusted and adjusted analyses (adjusted odds ratio 1.73 with 95% CI: 1.13-2.67).

CONCLUSION

No or <2 weeks of breastfeeding was associated with elevated risk of schizophrenia. The hypothesis of some protective effect of breastfeeding against the risk of later schizophrenia is supported by our data.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Amager Hospital, Copenhagen University Hospital, Denmark.

    , ,

    Source

    Acta psychiatrica Scandinavica 112:1 2005 Jul pg 26-9

    MeSH

    Adult
    Breast Feeding
    Catchment Area (Health)
    Cohort Studies
    Denmark
    Female
    Humans
    Infant, Newborn
    Male
    Mothers
    Risk Factors
    Schizophrenia
    Sex Factors
    Single Parent
    Social Class
    Weaning

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15952942

    Citation

    Sørensen, H J., et al. "Breastfeeding and Risk of Schizophrenia in the Copenhagen Perinatal Cohort." Acta Psychiatrica Scandinavica, vol. 112, no. 1, 2005, pp. 26-9.
    Sørensen HJ, Mortensen EL, Reinisch JM, et al. Breastfeeding and risk of schizophrenia in the Copenhagen Perinatal Cohort. Acta Psychiatr Scand. 2005;112(1):26-9.
    Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2005). Breastfeeding and risk of schizophrenia in the Copenhagen Perinatal Cohort. Acta Psychiatrica Scandinavica, 112(1), pp. 26-9.
    Sørensen HJ, et al. Breastfeeding and Risk of Schizophrenia in the Copenhagen Perinatal Cohort. Acta Psychiatr Scand. 2005;112(1):26-9. PubMed PMID: 15952942.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breastfeeding and risk of schizophrenia in the Copenhagen Perinatal Cohort. AU - Sørensen,H J, AU - Mortensen,E L, AU - Reinisch,J M, AU - Mednick,S A, PY - 2005/6/15/pubmed PY - 2005/10/21/medline PY - 2005/6/15/entrez SP - 26 EP - 9 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 112 IS - 1 N2 - OBJECTIVE: The aim was to study whether early weaning from breastfeeding may be associated with increased risk of schizophrenia. METHOD: The current sample comprises 6841 individuals from the Copenhagen Perinatal Cohort of whom 1671 (24%) had been breastfed for 2 weeks or less (early weaning) and 5170 (76%) had been breastfed longer. Maternal schizophrenia, parental social status, single mother status and gender were included as covariates in a multiple regression analysis of the effect of early weaning on the risk of hospitalization with schizophrenia. RESULTS: The sample comprised 93 cases of schizophrenia (1.4%). Maternal schizophrenia was the strongest risk factor and a significant association between single mother status and elevated offspring risk of schizophrenia was also observed. Early weaning was significantly related to later schizophrenia in both unadjusted and adjusted analyses (adjusted odds ratio 1.73 with 95% CI: 1.13-2.67). CONCLUSION: No or <2 weeks of breastfeeding was associated with elevated risk of schizophrenia. The hypothesis of some protective effect of breastfeeding against the risk of later schizophrenia is supported by our data. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/15952942/full_citation L2 - https://doi.org/10.1111/j.1600-0447.2005.00548.x DB - PRIME DP - Unbound Medicine ER -