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Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage.

Abstract

INTRODUCTION

The need to detect pancreatic cancer at earlier stages is undisputed. We recorded the signs and symptoms of patients presenting with exocrine pancreatic cancer and evaluated their association with clinical characteristics such as tumour site and disease stage.

PATIENTS AND METHODS

All patients (n = 185) with exocrine pancreatic cancer newly diagnosed at five general hospitals in Eastern Spain were prospectively recruited over 5 years. Symptoms were elicited through personal interviews and signs were recorded by the attending physician on admission.

RESULTS

At diagnosis, one third of tumours of the pancreas head were in stage I and another third in stage IV. None of the tumours of the body and tail were in stage I, and over 80% were in stage IV (p < 0.001) . At presentation, the most frequent symptoms were asthenia (86%), anorexia (85%), weight-loss (85%), abdominal pain (79%), and choluria (59%). Cholestatic symptoms were more common in tumours affecting only the pancreatic head (p < 0.001) . There was a clear trend toward more localized tumours with increasing numbers of cholestatic signs (p < 0.001) . Asthenia, anorexia and weight-loss were unrelated to stage. An increased symptom-to-diagnosis interval was associated with more advanced stage (p = 0.048).

CONCLUSIONS

Proper attention to signs and symptoms, especially cholestasis, may help identify patients with pancreatic cancer at an earlier stage. Results also provide a current picture of the semiology of pancreatic cancer which could be of use in studies on the potential of proteomic tests in the early detection of this neoplasm.

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  • Authors+Show Affiliations

    ,

    Unidad de Epidemiología Clinica y Molecular del Cáncer, Instituto Municipal de Investigación Médica, Universidad Autónoma de Barcelona, Carrer del Dr. Aiguader 80, 08005 Barcelona, Spain. Mporta@imim.es

    , , , , , , , , , , , , ,

    Source

    MeSH

    Aged
    Female
    Humans
    Male
    Neoplasm Staging
    Pancreas, Exocrine
    Pancreatic Neoplasms
    Prospective Studies

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15960930

    Citation

    Porta, Miquel, et al. "Exocrine Pancreatic Cancer: Symptoms at Presentation and Their Relation to Tumour Site and Stage." Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, vol. 7, no. 5, 2005, pp. 189-97.
    Porta M, Fabregat X, Malats N, et al. Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage. Clin Transl Oncol. 2005;7(5):189-97.
    Porta, M., Fabregat, X., Malats, N., Guarner, L., Carrato, A., de Miguel, A., ... Real, F. X. (2005). Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 7(5), pp. 189-97.
    Porta M, et al. Exocrine Pancreatic Cancer: Symptoms at Presentation and Their Relation to Tumour Site and Stage. Clin Transl Oncol. 2005;7(5):189-97. PubMed PMID: 15960930.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage. AU - Porta,Miquel, AU - Fabregat,Xavier, AU - Malats,Núria, AU - Guarner,Luisa, AU - Carrato,Alfredo, AU - de Miguel,Ana, AU - Ruiz,Laura, AU - Jariod,Manuel, AU - Costafreda,Sergi, AU - Coll,Susana, AU - Alguacil,Juan, AU - Corominas,Josep M, AU - Solà,Ricard, AU - Salas,Antonio, AU - Real,Francisco X, PY - 2005/6/18/pubmed PY - 2005/9/2/medline PY - 2005/6/18/entrez SP - 189 EP - 97 JF - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico JO - Clin Transl Oncol VL - 7 IS - 5 N2 - INTRODUCTION: The need to detect pancreatic cancer at earlier stages is undisputed. We recorded the signs and symptoms of patients presenting with exocrine pancreatic cancer and evaluated their association with clinical characteristics such as tumour site and disease stage. PATIENTS AND METHODS: All patients (n = 185) with exocrine pancreatic cancer newly diagnosed at five general hospitals in Eastern Spain were prospectively recruited over 5 years. Symptoms were elicited through personal interviews and signs were recorded by the attending physician on admission. RESULTS: At diagnosis, one third of tumours of the pancreas head were in stage I and another third in stage IV. None of the tumours of the body and tail were in stage I, and over 80% were in stage IV (p < 0.001) . At presentation, the most frequent symptoms were asthenia (86%), anorexia (85%), weight-loss (85%), abdominal pain (79%), and choluria (59%). Cholestatic symptoms were more common in tumours affecting only the pancreatic head (p < 0.001) . There was a clear trend toward more localized tumours with increasing numbers of cholestatic signs (p < 0.001) . Asthenia, anorexia and weight-loss were unrelated to stage. An increased symptom-to-diagnosis interval was associated with more advanced stage (p = 0.048). CONCLUSIONS: Proper attention to signs and symptoms, especially cholestasis, may help identify patients with pancreatic cancer at an earlier stage. Results also provide a current picture of the semiology of pancreatic cancer which could be of use in studies on the potential of proteomic tests in the early detection of this neoplasm. SN - 1699-048X UR - https://www.unboundmedicine.com/medline/citation/15960930/full_citation L2 - http://www.diseaseinfosearch.org/result/5551 DB - PRIME DP - Unbound Medicine ER -