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Milk, milk products and lactose intake and ovarian cancer risk: a meta-analysis of epidemiological studies.

Abstract

It has been proposed, on the basis of animal models and ecological studies, that consumption or metabolism of dairy sugar may increase the risk of ovarian cancer. Case-control and cohort studies of the association between lactose and dairy food consumption and ovarian cancer risk, however, have yielded varied findings. We summarized the available literature on this topic using a meta-analytic approach. Random-effects models were used to estimate the summary relative risks (RR(summary)). A linear regression analysis of the natural logarithm of the RR was carried out to assess a possible dose-response relationship between lactose intake and ovarian cancer risk. Eighteen case-control and 3 prospective cohort studies were eligible for inclusion in the meta-analysis. The findings of case-control studies were heterogeneous, and, except for whole milk (RR(summary) for highest vs. lowest category = 1.27, 95% confidence interval [CI] = 0.97-1.68), do not provide evidence of positive associations between dairy food and lactose intakes with risk of ovarian cancer. In contrast, the 3 cohort studies are consistent and show significant positive associations between intakes of total dairy foods, low-fat milk, and lactose and risk of ovarian cancer. The RR(summary) for a daily increase of 10 g in lactose intake (the approximate amount in 1 glass of milk) was 1.13 (95% CI = 1.05-1.22) for cohort studies. In conclusion, prospective cohort studies, but not case-control studies, support the hypothesis that high intakes of dairy foods and lactose may increase the risk of ovarian cancer.

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@imm.ki.se

    ,

    Source

    International journal of cancer 118:2 2006 Jan 15 pg 431-41

    MeSH

    Animals
    Case-Control Studies
    Cohort Studies
    Epidemiologic Studies
    Female
    Humans
    Lactose Intolerance
    Milk
    Ovarian Neoplasms
    Regression Analysis
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16052536

    Citation

    Larsson, Susanna C., et al. "Milk, Milk Products and Lactose Intake and Ovarian Cancer Risk: a Meta-analysis of Epidemiological Studies." International Journal of Cancer, vol. 118, no. 2, 2006, pp. 431-41.
    Larsson SC, Orsini N, Wolk A. Milk, milk products and lactose intake and ovarian cancer risk: a meta-analysis of epidemiological studies. Int J Cancer. 2006;118(2):431-41.
    Larsson, S. C., Orsini, N., & Wolk, A. (2006). Milk, milk products and lactose intake and ovarian cancer risk: a meta-analysis of epidemiological studies. International Journal of Cancer, 118(2), pp. 431-41.
    Larsson SC, Orsini N, Wolk A. Milk, Milk Products and Lactose Intake and Ovarian Cancer Risk: a Meta-analysis of Epidemiological Studies. Int J Cancer. 2006 Jan 15;118(2):431-41. PubMed PMID: 16052536.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Milk, milk products and lactose intake and ovarian cancer risk: a meta-analysis of epidemiological studies. AU - Larsson,Susanna C, AU - Orsini,Nicola, AU - Wolk,Alicja, PY - 2005/7/30/pubmed PY - 2006/1/13/medline PY - 2005/7/30/entrez SP - 431 EP - 41 JF - International journal of cancer JO - Int. J. Cancer VL - 118 IS - 2 N2 - It has been proposed, on the basis of animal models and ecological studies, that consumption or metabolism of dairy sugar may increase the risk of ovarian cancer. Case-control and cohort studies of the association between lactose and dairy food consumption and ovarian cancer risk, however, have yielded varied findings. We summarized the available literature on this topic using a meta-analytic approach. Random-effects models were used to estimate the summary relative risks (RR(summary)). A linear regression analysis of the natural logarithm of the RR was carried out to assess a possible dose-response relationship between lactose intake and ovarian cancer risk. Eighteen case-control and 3 prospective cohort studies were eligible for inclusion in the meta-analysis. The findings of case-control studies were heterogeneous, and, except for whole milk (RR(summary) for highest vs. lowest category = 1.27, 95% confidence interval [CI] = 0.97-1.68), do not provide evidence of positive associations between dairy food and lactose intakes with risk of ovarian cancer. In contrast, the 3 cohort studies are consistent and show significant positive associations between intakes of total dairy foods, low-fat milk, and lactose and risk of ovarian cancer. The RR(summary) for a daily increase of 10 g in lactose intake (the approximate amount in 1 glass of milk) was 1.13 (95% CI = 1.05-1.22) for cohort studies. In conclusion, prospective cohort studies, but not case-control studies, support the hypothesis that high intakes of dairy foods and lactose may increase the risk of ovarian cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/16052536/full_citation L2 - https://doi.org/10.1002/ijc.21305 DB - PRIME DP - Unbound Medicine ER -