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Mood disorders in the medically ill: scientific review and recommendations.

Abstract

OBJECTIVE

The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical practice and research.

DATA SOURCES

Data were culled from the 2002 Depression and Bipolar Support Alliance Conference proceedings and a literature review addressing prevalence, risk factors, diagnosis, and treatment. This review also considered the experience of primary and specialty care providers, policy analysts, and patient advocates. The review and recommendations reflect the expert opinion of the authors.

STUDY SELECTION/DATA EXTRACTION

Reviews of epidemiology and mechanistic studies were included, as were open-label and randomized, controlled trials on treatment of depression in patients with medical comorbidities. Data on study design, population, and results were extracted for review of evidence that includes tables of prevalence and pharmacological treatment. The effect of depression and bipolar disorder on selected medical comorbidities was assessed, and recommendations for practice, research, and policy were developed.

CONCLUSIONS

A growing body of evidence suggests that biological mechanisms underlie a bidirectional link between mood disorders and many medical illnesses. In addition, there is evidence to suggest that mood disorders affect the course of medical illnesses. Further prospective studies are warranted.

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  • Authors+Show Affiliations

    ,

    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA. psych@mail.med.upenn.edu

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    Biological psychiatry 58:3 2005 Aug 01 pg 175-89

    MeSH

    Acquired Immunodeficiency Syndrome
    Brain Diseases
    Cerebrovascular Disorders
    Comorbidity
    Delivery of Health Care
    Diabetes Complications
    Humans
    Mood Disorders
    Neoplasms
    Obesity
    Osteoporosis
    Pain
    Practice Guidelines as Topic
    Prevalence

    Pub Type(s)

    Consensus Development Conference
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    16084838

    Citation

    Evans, Dwight L., et al. "Mood Disorders in the Medically Ill: Scientific Review and Recommendations." Biological Psychiatry, vol. 58, no. 3, 2005, pp. 175-89.
    Evans DL, Charney DS, Lewis L, et al. Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry. 2005;58(3):175-89.
    Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R., ... Valvo, W. J. (2005). Mood disorders in the medically ill: scientific review and recommendations. Biological Psychiatry, 58(3), pp. 175-89.
    Evans DL, et al. Mood Disorders in the Medically Ill: Scientific Review and Recommendations. Biol Psychiatry. 2005 Aug 1;58(3):175-89. PubMed PMID: 16084838.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mood disorders in the medically ill: scientific review and recommendations. AU - Evans,Dwight L, AU - Charney,Dennis S, AU - Lewis,Lydia, AU - Golden,Robert N, AU - Gorman,Jack M, AU - Krishnan,K Ranga Rama, AU - Nemeroff,Charles B, AU - Bremner,J Douglas, AU - Carney,Robert M, AU - Coyne,James C, AU - Delong,Mahlon R, AU - Frasure-Smith,Nancy, AU - Glassman,Alexander H, AU - Gold,Philip W, AU - Grant,Igor, AU - Gwyther,Lisa, AU - Ironson,Gail, AU - Johnson,Robert L, AU - Kanner,Andres M, AU - Katon,Wayne J, AU - Kaufmann,Peter G, AU - Keefe,Francis J, AU - Ketter,Terence, AU - Laughren,Thomas P, AU - Leserman,Jane, AU - Lyketsos,Constantine G, AU - McDonald,William M, AU - McEwen,Bruce S, AU - Miller,Andrew H, AU - Musselman,Dominique, AU - O'Connor,Christopher, AU - Petitto,John M, AU - Pollock,Bruce G, AU - Robinson,Robert G, AU - Roose,Steven P, AU - Rowland,Julia, AU - Sheline,Yvette, AU - Sheps,David S, AU - Simon,Gregory, AU - Spiegel,David, AU - Stunkard,Albert, AU - Sunderland,Trey, AU - Tibbits,Paul,Jr AU - Valvo,William J, PY - 2005/01/13/received PY - 2005/04/29/revised PY - 2005/05/03/accepted PY - 2005/8/9/pubmed PY - 2005/9/20/medline PY - 2005/8/9/entrez SP - 175 EP - 89 JF - Biological psychiatry JO - Biol. Psychiatry VL - 58 IS - 3 N2 - OBJECTIVE: The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical practice and research. DATA SOURCES: Data were culled from the 2002 Depression and Bipolar Support Alliance Conference proceedings and a literature review addressing prevalence, risk factors, diagnosis, and treatment. This review also considered the experience of primary and specialty care providers, policy analysts, and patient advocates. The review and recommendations reflect the expert opinion of the authors. STUDY SELECTION/DATA EXTRACTION: Reviews of epidemiology and mechanistic studies were included, as were open-label and randomized, controlled trials on treatment of depression in patients with medical comorbidities. Data on study design, population, and results were extracted for review of evidence that includes tables of prevalence and pharmacological treatment. The effect of depression and bipolar disorder on selected medical comorbidities was assessed, and recommendations for practice, research, and policy were developed. CONCLUSIONS: A growing body of evidence suggests that biological mechanisms underlie a bidirectional link between mood disorders and many medical illnesses. In addition, there is evidence to suggest that mood disorders affect the course of medical illnesses. Further prospective studies are warranted. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16084838/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(05)00574-3 DB - PRIME DP - Unbound Medicine ER -