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Dietary beta-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study.

Abstract

BACKGROUND

Epidemiologic studies suggest that the antioxidant potential of dietary carotenoids may protect against the oxidative damage that can result in inflammation.

OBJECTIVE

We investigated the hypothesis that some dietary carotenoids are associated with a reduced risk of developing inflammatory polyarthritis (IP).

DESIGN

The European Prospective Investigation of Cancer Incidence (EPIC)-Norfolk study is a population-based, prospective study of >25,000 subjects who completed a baseline 7-d diet diary and were followed up to identify new cases of IP, which was defined as synovitis that affected > or = 2 joint groups. Dietary carotenoid intakes were computed from the diet diaries of these subjects, and a nested, case-control analysis was undertaken to compare carotenoid intake between case subjects and age- and sex-matched control subjects.

RESULTS

Eighty-eight incident cases of IP that occurred in the population surveyed were ascertained via the Norfolk Arthritis Register. The mean daily intakes of zeaxanthin and beta-cryptoxanthin were 20% and 40% lower, respectively, in the cases than in the 176 controls, but there were no significant differences in the intakes of either lutein or lycopene. Those subjects in the top one-third of intake of zeaxanthin and beta-cryptoxanthin were at a lower risk of developing IP than were subjects in the lowest one-third [odds ratios (95% CI): 0.48 (0.24, 0.94) and 0.51 (0.25, 1.02) for zeaxanthin and beta-cryptoxanthin, respectively]. The association with beta-cryptoxanthin was significant after adjustments were made for total energy and protein intakes and for cigarette smoking.

CONCLUSION

These data are consistent with previous evidence showing that a modest increase in beta-cryptoxanthin intake, equivalent to one glass of freshly squeezed orange juice per day, is associated with a reduced risk of developing inflammatory disorders such as rheumatoid arthritis.

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  • Authors+Show Affiliations

    ,

    Arthritis Research Campaign Epidemiology Unit, The University of Manchester, Manchester, United Kingdom.

    , , , , ,

    Source

    MeSH

    Aged
    Antioxidants
    Arthritis
    Case-Control Studies
    Cryptoxanthins
    Female
    Humans
    Male
    Middle Aged
    Prospective Studies
    Xanthophylls
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16087992

    Citation

    Pattison, Dorothy J., et al. "Dietary Beta-cryptoxanthin and Inflammatory Polyarthritis: Results From a Population-based Prospective Study." The American Journal of Clinical Nutrition, vol. 82, no. 2, 2005, pp. 451-5.
    Pattison DJ, Symmons DP, Lunt M, et al. Dietary beta-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study. Am J Clin Nutr. 2005;82(2):451-5.
    Pattison, D. J., Symmons, D. P., Lunt, M., Welch, A., Bingham, S. A., Day, N. E., & Silman, A. J. (2005). Dietary beta-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study. The American Journal of Clinical Nutrition, 82(2), pp. 451-5.
    Pattison DJ, et al. Dietary Beta-cryptoxanthin and Inflammatory Polyarthritis: Results From a Population-based Prospective Study. Am J Clin Nutr. 2005;82(2):451-5. PubMed PMID: 16087992.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary beta-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study. AU - Pattison,Dorothy J, AU - Symmons,Deborah P M, AU - Lunt,Mark, AU - Welch,Ailsa, AU - Bingham,Sheila A, AU - Day,Nicholas E, AU - Silman,Alan J, PY - 2005/8/10/pubmed PY - 2005/9/2/medline PY - 2005/8/10/entrez SP - 451 EP - 5 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 82 IS - 2 N2 - BACKGROUND: Epidemiologic studies suggest that the antioxidant potential of dietary carotenoids may protect against the oxidative damage that can result in inflammation. OBJECTIVE: We investigated the hypothesis that some dietary carotenoids are associated with a reduced risk of developing inflammatory polyarthritis (IP). DESIGN: The European Prospective Investigation of Cancer Incidence (EPIC)-Norfolk study is a population-based, prospective study of >25,000 subjects who completed a baseline 7-d diet diary and were followed up to identify new cases of IP, which was defined as synovitis that affected > or = 2 joint groups. Dietary carotenoid intakes were computed from the diet diaries of these subjects, and a nested, case-control analysis was undertaken to compare carotenoid intake between case subjects and age- and sex-matched control subjects. RESULTS: Eighty-eight incident cases of IP that occurred in the population surveyed were ascertained via the Norfolk Arthritis Register. The mean daily intakes of zeaxanthin and beta-cryptoxanthin were 20% and 40% lower, respectively, in the cases than in the 176 controls, but there were no significant differences in the intakes of either lutein or lycopene. Those subjects in the top one-third of intake of zeaxanthin and beta-cryptoxanthin were at a lower risk of developing IP than were subjects in the lowest one-third [odds ratios (95% CI): 0.48 (0.24, 0.94) and 0.51 (0.25, 1.02) for zeaxanthin and beta-cryptoxanthin, respectively]. The association with beta-cryptoxanthin was significant after adjustments were made for total energy and protein intakes and for cigarette smoking. CONCLUSION: These data are consistent with previous evidence showing that a modest increase in beta-cryptoxanthin intake, equivalent to one glass of freshly squeezed orange juice per day, is associated with a reduced risk of developing inflammatory disorders such as rheumatoid arthritis. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16087992/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn.82.2.451 DB - PRIME DP - Unbound Medicine ER -