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Avian flu: isolation of drug-resistant H5N1 virus.

Abstract

The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.

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  • Authors+Show Affiliations

    ,

    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.

    , , , , , , , , , , , , , ,

    Source

    Nature 437:7062 2005 Oct 20 pg 1108

    MeSH

    Acetamides
    Adolescent
    Adult
    DNA Mutational Analysis
    Drug Resistance, Viral
    Female
    Ferrets
    Guanidines
    Hemagglutinin Glycoproteins, Influenza Virus
    Humans
    Influenza A Virus, H5N1 Subtype
    Influenza A virus
    Influenza, Human
    Inhibitory Concentration 50
    Mutation
    Neuraminidase
    Oseltamivir
    Polymerase Chain Reaction
    Pyrans
    Sialic Acids
    Zanamivir

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    16228009

    Citation

    TY - JOUR T1 - Avian flu: isolation of drug-resistant H5N1 virus. AU - Le,Q Mai, AU - Kiso,Maki, AU - Someya,Kazuhiko, AU - Sakai,Yuko T, AU - Nguyen,T Hien, AU - Nguyen,Khan H L, AU - Pham,N Dinh, AU - Ngyen,Ha H, AU - Yamada,Shinya, AU - Muramoto,Yukiko, AU - Horimoto,Taisuke, AU - Takada,Ayato, AU - Goto,Hideo, AU - Suzuki,Takashi, AU - Suzuki,Yasuo, AU - Kawaoka,Yoshihiro, PY - 2005/10/18/pubmed PY - 2005/10/29/medline PY - 2005/10/18/entrez SP - 1108 EP - 1108 JF - Nature JO - Nature VL - 437 IS - 7062 N2 - The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/16228009/full_citation L2 - http://dx.doi.org/10.1038/4371108a ER -