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Avian flu: isolation of drug-resistant H5N1 virus.
Nature 2005; 437(7062):1108Nat

Abstract

The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.

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    Authors+Show Affiliations

    Le QM
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
    Kiso M
    No affiliation info available
    Someya K
    No affiliation info available
    Sakai YT
    No affiliation info available
    Nguyen TH
    No affiliation info available
    Nguyen KH
    No affiliation info available
    Pham ND
    No affiliation info available
    Ngyen HH
    No affiliation info available
    Yamada S
    No affiliation info available
    Muramoto Y
    No affiliation info available
    Horimoto T
    No affiliation info available
    Takada A
    No affiliation info available
    Goto H
    No affiliation info available
    Suzuki T
    No affiliation info available
    Suzuki Y
    No affiliation info available
    Kawaoka Y
    No affiliation info available

    MeSH

    AcetamidesAdolescentAdultDNA Mutational AnalysisDrug Resistance, ViralFemaleFerretsGuanidinesHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H5N1 SubtypeInfluenza A virusInfluenza, HumanInhibitory Concentration 50MutationNeuraminidaseOseltamivirPolymerase Chain ReactionPyransSialic AcidsZanamivir

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    16228009

    Citation

    Le, Q Mai, et al. "Avian Flu: Isolation of Drug-resistant H5N1 Virus." Nature, vol. 437, no. 7062, 2005, p. 1108.
    Le QM, Kiso M, Someya K, et al. Avian flu: isolation of drug-resistant H5N1 virus. Nature. 2005;437(7062):1108.
    Le, Q. M., Kiso, M., Someya, K., Sakai, Y. T., Nguyen, T. H., Nguyen, K. H., ... Kawaoka, Y. (2005). Avian flu: isolation of drug-resistant H5N1 virus. Nature, 437(7062), p. 1108.
    Le QM, et al. Avian Flu: Isolation of Drug-resistant H5N1 Virus. Nature. 2005 Oct 20;437(7062):1108. PubMed PMID: 16228009.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Avian flu: isolation of drug-resistant H5N1 virus. AU - Le,Q Mai, AU - Kiso,Maki, AU - Someya,Kazuhiko, AU - Sakai,Yuko T, AU - Nguyen,T Hien, AU - Nguyen,Khan H L, AU - Pham,N Dinh, AU - Ngyen,Ha H, AU - Yamada,Shinya, AU - Muramoto,Yukiko, AU - Horimoto,Taisuke, AU - Takada,Ayato, AU - Goto,Hideo, AU - Suzuki,Takashi, AU - Suzuki,Yasuo, AU - Kawaoka,Yoshihiro, PY - 2005/10/18/pubmed PY - 2005/10/29/medline PY - 2005/10/18/entrez SP - 1108 EP - 1108 JF - Nature JO - Nature VL - 437 IS - 7062 N2 - The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/16228009/full_citation L2 - https://doi.org/10.1038/4371108a DB - PRIME DP - Unbound Medicine ER -