Avian flu: isolation of drug-resistant H5N1 virus.Nature. 2005 Oct 20; 437(7062):1108.Nat
Abstract
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
MeSH
AcetamidesAdolescentAdultDNA Mutational AnalysisDrug Resistance, ViralFemaleFerretsGuanidinesHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H5N1 SubtypeInfluenza A virusInfluenza, HumanInhibitory Concentration 50MutationNeuraminidaseOseltamivirPolymerase Chain ReactionPyransSialic AcidsZanamivir
Pub Type(s)
Case Reports
Journal Article
Language
eng
PubMed ID
16228009
Citation
Le, Q Mai, et al. "Avian Flu: Isolation of Drug-resistant H5N1 Virus." Nature, vol. 437, no. 7062, 2005, p. 1108.
Le QM, Kiso M, Someya K, et al. Avian flu: isolation of drug-resistant H5N1 virus. Nature. 2005;437(7062):1108.
Le, Q. M., Kiso, M., Someya, K., Sakai, Y. T., Nguyen, T. H., Nguyen, K. H., Pham, N. D., Ngyen, H. H., Yamada, S., Muramoto, Y., Horimoto, T., Takada, A., Goto, H., Suzuki, T., Suzuki, Y., & Kawaoka, Y. (2005). Avian flu: isolation of drug-resistant H5N1 virus. Nature, 437(7062), 1108.
Le QM, et al. Avian Flu: Isolation of Drug-resistant H5N1 Virus. Nature. 2005 Oct 20;437(7062):1108. PubMed PMID: 16228009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Avian flu: isolation of drug-resistant H5N1 virus.
AU - Le,Q Mai,
AU - Kiso,Maki,
AU - Someya,Kazuhiko,
AU - Sakai,Yuko T,
AU - Nguyen,T Hien,
AU - Nguyen,Khan H L,
AU - Pham,N Dinh,
AU - Ngyen,Ha H,
AU - Yamada,Shinya,
AU - Muramoto,Yukiko,
AU - Horimoto,Taisuke,
AU - Takada,Ayato,
AU - Goto,Hideo,
AU - Suzuki,Takashi,
AU - Suzuki,Yasuo,
AU - Kawaoka,Yoshihiro,
PY - 2005/10/18/pubmed
PY - 2005/10/29/medline
PY - 2005/10/18/entrez
SP - 1108
EP - 1108
JF - Nature
JO - Nature
VL - 437
IS - 7062
N2 - The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
SN - 1476-4687
UR - https://www.unboundmedicine.com/medline/citation/16228009/full_citation
DB - PRIME
DP - Unbound Medicine
ER -