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Avian flu: isolation of drug-resistant H5N1 virus.
Nature. 2005 Oct 20; 437(7062):1108.Nat

Abstract

The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.

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Authors+Show Affiliations

Le QM
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Kiso M
No affiliation info available
Someya K
No affiliation info available
Sakai YT
No affiliation info available
Nguyen TH
No affiliation info available
Nguyen KH
No affiliation info available
Pham ND
No affiliation info available
Ngyen HH
No affiliation info available
Yamada S
No affiliation info available
Muramoto Y
No affiliation info available
Horimoto T
No affiliation info available
Takada A
No affiliation info available
Goto H
No affiliation info available
Suzuki T
No affiliation info available
Suzuki Y
No affiliation info available
Kawaoka Y
No affiliation info available

MeSH

AcetamidesAdolescentAdultDNA Mutational AnalysisDrug Resistance, ViralFemaleFerretsGuanidinesHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H5N1 SubtypeInfluenza A virusInfluenza, HumanInhibitory Concentration 50MutationNeuraminidaseOseltamivirPolymerase Chain ReactionPyransSialic AcidsZanamivir

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16228009

Citation

Le, Q Mai, et al. "Avian Flu: Isolation of Drug-resistant H5N1 Virus." Nature, vol. 437, no. 7062, 2005, p. 1108.
Le QM, Kiso M, Someya K, et al. Avian flu: isolation of drug-resistant H5N1 virus. Nature. 2005;437(7062):1108.
Le, Q. M., Kiso, M., Someya, K., Sakai, Y. T., Nguyen, T. H., Nguyen, K. H., Pham, N. D., Ngyen, H. H., Yamada, S., Muramoto, Y., Horimoto, T., Takada, A., Goto, H., Suzuki, T., Suzuki, Y., & Kawaoka, Y. (2005). Avian flu: isolation of drug-resistant H5N1 virus. Nature, 437(7062), 1108.
Le QM, et al. Avian Flu: Isolation of Drug-resistant H5N1 Virus. Nature. 2005 Oct 20;437(7062):1108. PubMed PMID: 16228009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Avian flu: isolation of drug-resistant H5N1 virus. AU - Le,Q Mai, AU - Kiso,Maki, AU - Someya,Kazuhiko, AU - Sakai,Yuko T, AU - Nguyen,T Hien, AU - Nguyen,Khan H L, AU - Pham,N Dinh, AU - Ngyen,Ha H, AU - Yamada,Shinya, AU - Muramoto,Yukiko, AU - Horimoto,Taisuke, AU - Takada,Ayato, AU - Goto,Hideo, AU - Suzuki,Takashi, AU - Suzuki,Yasuo, AU - Kawaoka,Yoshihiro, PY - 2005/10/18/pubmed PY - 2005/10/29/medline PY - 2005/10/18/entrez SP - 1108 EP - 1108 JF - Nature JO - Nature VL - 437 IS - 7062 N2 - The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/16228009/full_citation L2 - https://doi.org/10.1038/4371108a DB - PRIME DP - Unbound Medicine ER -