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Avian flu: isolation of drug-resistant H5N1 virus.
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam., , , , , , , , , , , , , ,
DNA Mutational Analysis
Drug Resistance, Viral
Hemagglutinin Glycoproteins, Influenza Virus
Influenza A Virus, H5N1 Subtype
Influenza A virus
Inhibitory Concentration 50
Polymerase Chain Reaction
Pub Type(s)Case Reports