Avian flu: isolation of drug-resistant H5N1 virus.
Abstract
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
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Authors+Show Affiliations
,National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
, , , , , , , , , , , , , ,Source
Nature 437:7062 2005 Oct 20 pg 1108
MeSH
AcetamidesAdolescent
Adult
DNA Mutational Analysis
Drug Resistance, Viral
Female
Ferrets
Guanidines
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza A Virus, H5N1 Subtype
Influenza A virus
Influenza, Human
Inhibitory Concentration 50
Mutation
Neuraminidase
Oseltamivir
Polymerase Chain Reaction
Pyrans
Sialic Acids
Zanamivir
Pub Type(s)
Case ReportsJournal Article
Language
eng
PubMed ID
16228009
Citation
* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Avian flu: isolation of drug-resistant H5N1 virus.
AU - Le,Q Mai,
AU - Kiso,Maki,
AU - Someya,Kazuhiko,
AU - Sakai,Yuko T,
AU - Nguyen,T Hien,
AU - Nguyen,Khan H L,
AU - Pham,N Dinh,
AU - Ngyen,Ha H,
AU - Yamada,Shinya,
AU - Muramoto,Yukiko,
AU - Horimoto,Taisuke,
AU - Takada,Ayato,
AU - Goto,Hideo,
AU - Suzuki,Takashi,
AU - Suzuki,Yasuo,
AU - Kawaoka,Yoshihiro,
PY - 2005/10/18/pubmed
PY - 2005/10/29/medline
PY - 2005/10/18/entrez
SP - 1108
EP - 1108
JF - Nature
JO - Nature
VL - 437
IS - 7062
N2 - The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
SN - 1476-4687
UR - https://www.unboundmedicine.com/medline/citation/16228009/full_citation
L2 - https://doi.org/10.1038/4371108a
DB - PRIME
DP - Unbound Medicine
ER -