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Nonlinear optical studies of the agricultural antibiotic morantel interacting with silica/water interfaces.

Abstract

It is now known that the untreated discharge of pharmaceuticals into the environment can impact human health and development and lead to increased drug resistance in biota. Here, we present the first direct interface-specific studies that address the mobility of the widely used agricultural antibiotic morantel, which is commonly present in farm runoff. Surface-bound morantel was spectroscopically identified using second harmonic generation (SHG) via a two-photon resonance of its n-pi* transition and in the C-H stretching region by vibrational sum frequency generation (VSFG). Resonantly enhanced SHG adsorption isotherm measurements carried out at the silica/water interface between 6 x 10(-7) and 5 x 10(-5) M morantel concentration result in a free energy of adsorption of 42(2) kJ/mol at pH 7. Finally, real-time tracking of morantel interaction with the silica/water interface shows that the binding events are fully reversible, consistent with its high mobility in silica-rich soil environments. This work thus indicates that pharmaceuticals discharged into the environment can enter the groundwater supply of municipal water systems, at which point their removal is challenging. In addition, the high mobility of morantel in silica-rich soil environments could lead to developing increased interaction of this antibiotic with target organisms, which could respond by increased drug resistance.

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  • Authors+Show Affiliations

    ,

    Department of Chemistry and the Institute for Environmental Catalysis, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.

    , , , , , ,

    Source

    Journal of the American Chemical Society 127:45 2005 Nov 16 pg 15771-7

    MeSH

    Antinematodal Agents
    Environment
    Lasers
    Morantel
    Optics and Photonics
    Silicon Dioxide
    Spectrophotometry, Ultraviolet
    Spectrum Analysis
    Water

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    16277520

    Citation

    Konek, Christopher T., et al. "Nonlinear Optical Studies of the Agricultural Antibiotic Morantel Interacting With Silica/water Interfaces." Journal of the American Chemical Society, vol. 127, no. 45, 2005, pp. 15771-7.
    Konek CT, Illg KD, Al-Abadleh HA, et al. Nonlinear optical studies of the agricultural antibiotic morantel interacting with silica/water interfaces. J Am Chem Soc. 2005;127(45):15771-7.
    Konek, C. T., Illg, K. D., Al-Abadleh, H. A., Voges, A. B., Yin, G., Musorrafiti, M. J., ... Geiger, F. M. (2005). Nonlinear optical studies of the agricultural antibiotic morantel interacting with silica/water interfaces. Journal of the American Chemical Society, 127(45), pp. 15771-7.
    Konek CT, et al. Nonlinear Optical Studies of the Agricultural Antibiotic Morantel Interacting With Silica/water Interfaces. J Am Chem Soc. 2005 Nov 16;127(45):15771-7. PubMed PMID: 16277520.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nonlinear optical studies of the agricultural antibiotic morantel interacting with silica/water interfaces. AU - Konek,Christopher T, AU - Illg,Kimberly D, AU - Al-Abadleh,Hind A, AU - Voges,Andrea B, AU - Yin,Grace, AU - Musorrafiti,Michael J, AU - Schmidt,Catherine M, AU - Geiger,Franz M, PY - 2005/11/10/pubmed PY - 2006/1/26/medline PY - 2005/11/10/entrez SP - 15771 EP - 7 JF - Journal of the American Chemical Society JO - J. Am. Chem. Soc. VL - 127 IS - 45 N2 - It is now known that the untreated discharge of pharmaceuticals into the environment can impact human health and development and lead to increased drug resistance in biota. Here, we present the first direct interface-specific studies that address the mobility of the widely used agricultural antibiotic morantel, which is commonly present in farm runoff. Surface-bound morantel was spectroscopically identified using second harmonic generation (SHG) via a two-photon resonance of its n-pi* transition and in the C-H stretching region by vibrational sum frequency generation (VSFG). Resonantly enhanced SHG adsorption isotherm measurements carried out at the silica/water interface between 6 x 10(-7) and 5 x 10(-5) M morantel concentration result in a free energy of adsorption of 42(2) kJ/mol at pH 7. Finally, real-time tracking of morantel interaction with the silica/water interface shows that the binding events are fully reversible, consistent with its high mobility in silica-rich soil environments. This work thus indicates that pharmaceuticals discharged into the environment can enter the groundwater supply of municipal water systems, at which point their removal is challenging. In addition, the high mobility of morantel in silica-rich soil environments could lead to developing increased interaction of this antibiotic with target organisms, which could respond by increased drug resistance. SN - 0002-7863 UR - https://www.unboundmedicine.com/medline/citation/16277520/full_citation L2 - https://dx.doi.org/10.1021/ja054837b DB - PRIME DP - Unbound Medicine ER -