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Fibrodysplasia ossificans progressiva: case report.
Arq Neuropsiquiatr. 2005 Dec; 63(4):1090-3.AN

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by postnatal progressive heterotopic ossification of the connective tissue and congenital malformation of the big toes. We report on a nine-year-old girl with clinical and radiological features of FOP. She was born with bilateral hallux valgus and at the age of nine presented an indurate mass in the left cervical region that was painful. A significant decreased range of motion in all levels of the spine and shoulder girdle was found. The radiographs showed heterotopic ossification in the thoracic region. The patient had two outbreaks of the disease ("flare-ups") that were treated with prednisone 2 mg/kg/day for four days. After the "flare-ups", she had a continuous therapy with a Cox-2 inhibitor (25 mg/day) and a leukotriene inhibitor, montelukast (10 mg/day).

Authors+Show Affiliations

Gonçalves AL
Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, SP, Brazil. goncalvesnp@yahoo.com.br
Masruha MR
No affiliation info available
de Campos CC
No affiliation info available
Delai PL
No affiliation info available
Vilanova LC
No affiliation info available

MeSH

AcetatesAdrenal Cortex HormonesChildCyclopropanesFemaleHumansLeukotriene AntagonistsMyositis OssificansQuinolinesSulfidesTomography, X-Ray Computed

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16400434

Citation

Gonçalves, Andre Leite, et al. "Fibrodysplasia Ossificans Progressiva: Case Report." Arquivos De Neuro-psiquiatria, vol. 63, no. 4, 2005, pp. 1090-3.
Gonçalves AL, Masruha MR, de Campos CC, et al. Fibrodysplasia ossificans progressiva: case report. Arq Neuropsiquiatr. 2005;63(4):1090-3.
Gonçalves, A. L., Masruha, M. R., de Campos, C. C., Delai, P. L., & Vilanova, L. C. (2005). Fibrodysplasia ossificans progressiva: case report. Arquivos De Neuro-psiquiatria, 63(4), 1090-3.
Gonçalves AL, et al. Fibrodysplasia Ossificans Progressiva: Case Report. Arq Neuropsiquiatr. 2005;63(4):1090-3. PubMed PMID: 16400434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibrodysplasia ossificans progressiva: case report. AU - Gonçalves,Andre Leite, AU - Masruha,Marcelo Rodrigues, AU - de Campos,Carmelinda Correia, AU - Delai,Patricia Longo Ribeiro, AU - Vilanova,Luiz Celso Pereira, Y1 - 2005/12/15/ PY - 2006/1/10/pubmed PY - 2006/6/2/medline PY - 2006/1/10/entrez SP - 1090 EP - 3 JF - Arquivos de neuro-psiquiatria JO - Arq Neuropsiquiatr VL - 63 IS - 4 N2 - Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by postnatal progressive heterotopic ossification of the connective tissue and congenital malformation of the big toes. We report on a nine-year-old girl with clinical and radiological features of FOP. She was born with bilateral hallux valgus and at the age of nine presented an indurate mass in the left cervical region that was painful. A significant decreased range of motion in all levels of the spine and shoulder girdle was found. The radiographs showed heterotopic ossification in the thoracic region. The patient had two outbreaks of the disease ("flare-ups") that were treated with prednisone 2 mg/kg/day for four days. After the "flare-ups", she had a continuous therapy with a Cox-2 inhibitor (25 mg/day) and a leukotriene inhibitor, montelukast (10 mg/day). SN - 0004-282X UR - https://www.unboundmedicine.com/medline/citation/16400434/Fibrodysplasia_ossificans_progressiva:_case_report DB - PRIME DP - Unbound Medicine ER -
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