Tags

Type your tag names separated by a space and hit enter

Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia.
Biol Psychiatry 2006; 60(3):265-9BP

Abstract

BACKGROUND

An elevated homocysteine level is reported to be a risk factor for several diseases, including Alzheimer's and cerebrovascular disease. Recently, several studies have reported that homocysteine levels are elevated in many schizophrenic patients. Homocysteine levels can be lowered by oral folic acid, B-12, and pyridoxine.

METHODS

Forty-two schizophrenic patients with plasma homocysteine levels >15 micromol/L were treated with these vitamins for 3 months and placebo for 3 months in a study with a randomized, double-blind, placebo-controlled, crossover design.

RESULTS

Homocysteine levels declined with vitamin therapy compared with placebo in all patients except for one noncompliant subject. Clinical symptoms of schizophrenia as measured by the Positive and Negative Syndrome Scale declined significantly with active treatment compared with placebo. Neuropsychological test results overall, and Wisconsin Card Sort (Categories Completed) test results in particular, were significantly better after vitamin treatment than after placebo.

CONCLUSIONS

A subgroup of schizophrenic patients with hyperhomocysteinemia might benefit from the simple addition of B vitamins.

Authors+Show Affiliations

Stanley Research Center and Beersheva Mental Health Center, Ben Gurion University of the Negev, Beersheva, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16412989

Citation

Levine, Joseph, et al. "Homocysteine-reducing Strategies Improve Symptoms in Chronic Schizophrenic Patients With Hyperhomocysteinemia." Biological Psychiatry, vol. 60, no. 3, 2006, pp. 265-9.
Levine J, Stahl Z, Sela BA, et al. Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia. Biol Psychiatry. 2006;60(3):265-9.
Levine, J., Stahl, Z., Sela, B. A., Ruderman, V., Shumaico, O., Babushkin, I., ... Belmaker, R. H. (2006). Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia. Biological Psychiatry, 60(3), pp. 265-9.
Levine J, et al. Homocysteine-reducing Strategies Improve Symptoms in Chronic Schizophrenic Patients With Hyperhomocysteinemia. Biol Psychiatry. 2006 Aug 1;60(3):265-9. PubMed PMID: 16412989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia. AU - Levine,Joseph, AU - Stahl,Ziva, AU - Sela,Ben-Ami, AU - Ruderman,Vladimir, AU - Shumaico,Oleg, AU - Babushkin,Ivgeny, AU - Osher,Yamima, AU - Bersudsky,Yuly, AU - Belmaker,R H, Y1 - 2006/01/17/ PY - 2005/02/11/received PY - 2005/08/21/revised PY - 2005/10/26/accepted PY - 2006/1/18/pubmed PY - 2006/9/23/medline PY - 2006/1/18/entrez SP - 265 EP - 9 JF - Biological psychiatry JO - Biol. Psychiatry VL - 60 IS - 3 N2 - BACKGROUND: An elevated homocysteine level is reported to be a risk factor for several diseases, including Alzheimer's and cerebrovascular disease. Recently, several studies have reported that homocysteine levels are elevated in many schizophrenic patients. Homocysteine levels can be lowered by oral folic acid, B-12, and pyridoxine. METHODS: Forty-two schizophrenic patients with plasma homocysteine levels >15 micromol/L were treated with these vitamins for 3 months and placebo for 3 months in a study with a randomized, double-blind, placebo-controlled, crossover design. RESULTS: Homocysteine levels declined with vitamin therapy compared with placebo in all patients except for one noncompliant subject. Clinical symptoms of schizophrenia as measured by the Positive and Negative Syndrome Scale declined significantly with active treatment compared with placebo. Neuropsychological test results overall, and Wisconsin Card Sort (Categories Completed) test results in particular, were significantly better after vitamin treatment than after placebo. CONCLUSIONS: A subgroup of schizophrenic patients with hyperhomocysteinemia might benefit from the simple addition of B vitamins. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16412989/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(05)01274-6 DB - PRIME DP - Unbound Medicine ER -