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Diabetic neuropathy.

Abstract

Diabetic neuropathy (DN) refers to symptoms and signs of neuropathy in a patient with diabetes in whom other causes of neuropathy have been excluded. Distal symmetrical neuropathy is the commonest accounting for 75% DN. Asymmetrical neuropathies may involve cranial nerves, thoracic or limb nerves; are of acute onset resulting from ischaemic infarction of vasa nervosa. Asymmetric neuropathies in diabetic patients should be investigated for entrapment neuropathy. Diabetic amyotrophy, initially considered to result from metabolic changes, and later ischaemia, is now attributed to immunological changes. For diagnosis of DN, symptoms, signs, quantitative sensory testing, nerve conduction study, and autonomic testing are used; and two of these five are recommended for clinical diagnosis. Management of DN includes control of hyperglycaemia, other cardiovascular risk factors; alpha lipoic acid and L carnitine. For neuropathic pain, analgesics, non-steroidal anti-inflammatory drugs, antidepressants, and anticonvulsants are recommended. The treatment of autonomic neuropathy is symptomatic.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India.

    ,

    Source

    Postgraduate medical journal 82:964 2006 Feb pg 95-100

    MeSH

    Aldehyde Reductase
    Antioxidants
    Autonomic Nervous System Diseases
    Chronic Disease
    Diabetic Neuropathies
    Humans
    Nootropic Agents
    Pain
    Risk Factors
    Thioctic Acid

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16461471

    Citation

    Bansal, V, et al. "Diabetic Neuropathy." Postgraduate Medical Journal, vol. 82, no. 964, 2006, pp. 95-100.
    Bansal V, Kalita J, Misra UK. Diabetic neuropathy. Postgrad Med J. 2006;82(964):95-100.
    Bansal, V., Kalita, J., & Misra, U. K. (2006). Diabetic neuropathy. Postgraduate Medical Journal, 82(964), pp. 95-100.
    Bansal V, Kalita J, Misra UK. Diabetic Neuropathy. Postgrad Med J. 2006;82(964):95-100. PubMed PMID: 16461471.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diabetic neuropathy. AU - Bansal,V, AU - Kalita,J, AU - Misra,U K, PY - 2006/2/8/pubmed PY - 2006/3/9/medline PY - 2006/2/8/entrez SP - 95 EP - 100 JF - Postgraduate medical journal JO - Postgrad Med J VL - 82 IS - 964 N2 - Diabetic neuropathy (DN) refers to symptoms and signs of neuropathy in a patient with diabetes in whom other causes of neuropathy have been excluded. Distal symmetrical neuropathy is the commonest accounting for 75% DN. Asymmetrical neuropathies may involve cranial nerves, thoracic or limb nerves; are of acute onset resulting from ischaemic infarction of vasa nervosa. Asymmetric neuropathies in diabetic patients should be investigated for entrapment neuropathy. Diabetic amyotrophy, initially considered to result from metabolic changes, and later ischaemia, is now attributed to immunological changes. For diagnosis of DN, symptoms, signs, quantitative sensory testing, nerve conduction study, and autonomic testing are used; and two of these five are recommended for clinical diagnosis. Management of DN includes control of hyperglycaemia, other cardiovascular risk factors; alpha lipoic acid and L carnitine. For neuropathic pain, analgesics, non-steroidal anti-inflammatory drugs, antidepressants, and anticonvulsants are recommended. The treatment of autonomic neuropathy is symptomatic. SN - 1469-0756 UR - https://www.unboundmedicine.com/medline/citation/16461471/full_citation L2 - http://pmj.bmj.com/cgi/pmidlookup?view=long&pmid=16461471 DB - PRIME DP - Unbound Medicine ER -