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HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections.

Abstract

Numerous epidemiologic studies have found significant associations between lack of circumcision and HIV-1 acquisition in men. To our knowledge, this is the first study of human foreskin tissue that examines biologic mechanisms that increase susceptibility of uncircumcised African men to HIV-1. Foreskin specimens from 20 men with and 19 men with no history of sexually transmitted infections were examined for HIV-1 target cells. Most Langerhans cells were found in the epithelium; most CD4+ T cells and macrophages were in the submucosa. There were no differences in HIV-1 target cells between men with and those without history of sexually transmitted infections. However Langerhans cells and macrophages were more abundant in the group with a history of infection. The densities and positions of HIV-1 target cells in the foreskin tissue of these Kenyan men indicate that the inner mucosal surface of the human foreskin contains cells that make it highly susceptible to HIV infection.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology, School of Public Health, University of Illinois, Chicago 60612, USA.

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Antigens, CD
    CD4-Positive T-Lymphocytes
    Circumcision, Male
    HIV-1
    Humans
    Immune System
    Immunohistochemistry
    Kenya
    Langerhans Cells
    Macrophages
    Male
    Penis
    Sexually Transmitted Diseases
    Skin

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16613341

    Citation

    Donoval, Betty A., et al. "HIV-1 Target Cells in Foreskins of African Men With Varying Histories of Sexually Transmitted Infections." American Journal of Clinical Pathology, vol. 125, no. 3, 2006, pp. 386-91.
    Donoval BA, Landay AL, Moses S, et al. HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections. Am J Clin Pathol. 2006;125(3):386-91.
    Donoval, B. A., Landay, A. L., Moses, S., Agot, K., Ndinya-Achola, J. O., Nyagaya, E. A., ... Bailey, R. C. (2006). HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections. American Journal of Clinical Pathology, 125(3), pp. 386-91.
    Donoval BA, et al. HIV-1 Target Cells in Foreskins of African Men With Varying Histories of Sexually Transmitted Infections. Am J Clin Pathol. 2006;125(3):386-91. PubMed PMID: 16613341.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections. AU - Donoval,Betty A, AU - Landay,Alan L, AU - Moses,Stephen, AU - Agot,Kawango, AU - Ndinya-Achola,J O, AU - Nyagaya,Edith A, AU - MacLean,Ian, AU - Bailey,Robert C, PY - 2006/4/15/pubmed PY - 2006/4/28/medline PY - 2006/4/15/entrez SP - 386 EP - 91 JF - American journal of clinical pathology JO - Am. J. Clin. Pathol. VL - 125 IS - 3 N2 - Numerous epidemiologic studies have found significant associations between lack of circumcision and HIV-1 acquisition in men. To our knowledge, this is the first study of human foreskin tissue that examines biologic mechanisms that increase susceptibility of uncircumcised African men to HIV-1. Foreskin specimens from 20 men with and 19 men with no history of sexually transmitted infections were examined for HIV-1 target cells. Most Langerhans cells were found in the epithelium; most CD4+ T cells and macrophages were in the submucosa. There were no differences in HIV-1 target cells between men with and those without history of sexually transmitted infections. However Langerhans cells and macrophages were more abundant in the group with a history of infection. The densities and positions of HIV-1 target cells in the foreskin tissue of these Kenyan men indicate that the inner mucosal surface of the human foreskin contains cells that make it highly susceptible to HIV infection. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/16613341/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16613341.ui DB - PRIME DP - Unbound Medicine ER -