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Effects of ranitidine for exercise induced gastric mucosal changes and bleeding.

Abstract

AIM

To evaluate the effect of ranitidine on gastric mucosal changes and on GI bleeding in long distance runners.

METHODS

Twenty-four long distance runners (M: 16, F: 8, age: 18.2 +/- 1.5 years) participated in this study. A symptom questionnaire, stool hemoccult test, and upper gastrointestinal (GI) endoscopy were performed on the subjects prior to the study. The subjects took oral ranitidine (150 mg, b.i.d.) for two weeks. The upper GI endoscopy and stool Hemoccult tests were repeated after the treatment.

RESULTS

Twenty-two of the 24 runners had at least one upper GI mucosal lesion before the medication. The Endoscopic improvements were seen in eleven of the 14 cases of erosive gastritis and four of the 5 cases of esophagitis. Six subjects were Heme occult positive prior to the study, but only one was positive after the medication.

CONCLUSION

Gastric mucosal lesions and GI bleeding in long distance runners seem to be associated to acid-related factors mediated by the high level of regular running. Ranitidine seems to be and effective prophylaxis to prevent gastric mucosal lesions and GI bleeding.

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  • Authors+Show Affiliations

    ,

    Department of Leisure and Sports, Wonkwang Health Science College, Iksan, South Korea.

    , , , , , , , ,

    Source

    World journal of gastroenterology 12:16 2006 Apr 28 pg 2579-83

    MeSH

    Adolescent
    Adult
    Anti-Ulcer Agents
    Female
    Gastric Mucosa
    Gastrointestinal Hemorrhage
    Gastroscopy
    Helicobacter pylori
    Humans
    Male
    Ranitidine
    Running

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16688805

    Citation

    Choi, Suck Jun, et al. "Effects of Ranitidine for Exercise Induced Gastric Mucosal Changes and Bleeding." World Journal of Gastroenterology, vol. 12, no. 16, 2006, pp. 2579-83.
    Choi SJ, Kim YS, Chae JR, et al. Effects of ranitidine for exercise induced gastric mucosal changes and bleeding. World J Gastroenterol. 2006;12(16):2579-83.
    Choi, S. J., Kim, Y. S., Chae, J. R., Cho, H. K., Kim, T. H., Sohn, Y. W., ... Choi, S. C. (2006). Effects of ranitidine for exercise induced gastric mucosal changes and bleeding. World Journal of Gastroenterology, 12(16), pp. 2579-83.
    Choi SJ, et al. Effects of Ranitidine for Exercise Induced Gastric Mucosal Changes and Bleeding. World J Gastroenterol. 2006 Apr 28;12(16):2579-83. PubMed PMID: 16688805.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of ranitidine for exercise induced gastric mucosal changes and bleeding. AU - Choi,Suck Jun, AU - Kim,Yong Sung, AU - Chae,Jeong Ryong, AU - Cho,Hong Kwan, AU - Kim,Tae Hyeon, AU - Sohn,Young Woo, AU - Oh,Yong Leol, AU - Seo,Geom Seog, AU - Nah,Yong-Ho, AU - Choi,Suck Chei, PY - 2006/5/12/pubmed PY - 2006/6/9/medline PY - 2006/5/12/entrez SP - 2579 EP - 83 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 12 IS - 16 N2 - AIM: To evaluate the effect of ranitidine on gastric mucosal changes and on GI bleeding in long distance runners. METHODS: Twenty-four long distance runners (M: 16, F: 8, age: 18.2 +/- 1.5 years) participated in this study. A symptom questionnaire, stool hemoccult test, and upper gastrointestinal (GI) endoscopy were performed on the subjects prior to the study. The subjects took oral ranitidine (150 mg, b.i.d.) for two weeks. The upper GI endoscopy and stool Hemoccult tests were repeated after the treatment. RESULTS: Twenty-two of the 24 runners had at least one upper GI mucosal lesion before the medication. The Endoscopic improvements were seen in eleven of the 14 cases of erosive gastritis and four of the 5 cases of esophagitis. Six subjects were Heme occult positive prior to the study, but only one was positive after the medication. CONCLUSION: Gastric mucosal lesions and GI bleeding in long distance runners seem to be associated to acid-related factors mediated by the high level of regular running. Ranitidine seems to be and effective prophylaxis to prevent gastric mucosal lesions and GI bleeding. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/16688805/full_citation L2 - http://www.wjgnet.com/1007-9327/full/v12/i16/2579.htm DB - PRIME DP - Unbound Medicine ER -