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Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort.
Am J Gastroenterol. 2006 May; 101(5):1012-23.AJ

Abstract

OBJECTIVES

Inflammatory bowel disease (IBD), comprising primarily of Crohn's disease (CD) and ulcerative colitis (UC), is increasingly prevalent in racial and ethnic minorities. This study was undertaken to characterize racial differences in disease phenotype in a predominantly adult population.

METHODS

Phenotype data on 830 non-Hispanic white, 127 non-Hispanic African American, and 169 Hispanic IBD patients, recruited from six academic centers, were abstracted from medical records and compiled in the NIDDK-IBD Genetics Consortium repository. We characterized racial differences in family history, disease location and behavior, surgical history, and extraintestinal manifestations (EIMs) using standardized definitions.

RESULTS

African American CD patients were more likely than whites to develop esophagogastroduodenal CD (OR = 2.8; 95% CI: 1.4-5.5), colorectal disease (OR = 1.9; 95% CI: 1.1-3.4), perianal disease (OR = 1.7; 95% CI: 1.03-2.8), but less likely to have ileal involvement (OR = 0.55; 95% CI: 0.32-0.96). They were also at higher risk for uveitis (OR = 5.5; 95% CI: 2.3-13.0) and sacroiliitis (OR = 4.0; 95% CI: 1.55-10.1). Hispanics had higher prevalence of perianal CD (OR = 2.9; 95% CI: 1.8-4.6) and erythema nodosum (3.3; 95% CI: 1.7-6.4). Among UC patients, Hispanics had more proximal disease extent. Both African American and Hispanic CD patients, but not UC patients, had lower prevalences of family history of IBD than their white counterparts.

CONCLUSIONS

There are racial differences in IBD family history, disease location, and EIMs that may reflect underlying genetic variations and have important implications for diagnosis and management of disease. These findings underscore the need for further studies in minority populations.

Authors+Show Affiliations

Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16696785

Citation

Nguyen, Geoffrey C., et al. "Inflammatory Bowel Disease Characteristics Among African Americans, Hispanics, and non-Hispanic Whites: Characterization of a Large North American Cohort." The American Journal of Gastroenterology, vol. 101, no. 5, 2006, pp. 1012-23.
Nguyen GC, Torres EA, Regueiro M, et al. Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort. Am J Gastroenterol. 2006;101(5):1012-23.
Nguyen, G. C., Torres, E. A., Regueiro, M., Bromfield, G., Bitton, A., Stempak, J., Dassopoulos, T., Schumm, P., Gregory, F. J., Griffiths, A. M., Hanauer, S. B., Hanson, J., Harris, M. L., Kane, S. V., Orkwis, H. K., Lahaie, R., Oliva-Hemker, M., Pare, P., Wild, G. E., ... Silverberg, M. S. (2006). Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort. The American Journal of Gastroenterology, 101(5), 1012-23.
Nguyen GC, et al. Inflammatory Bowel Disease Characteristics Among African Americans, Hispanics, and non-Hispanic Whites: Characterization of a Large North American Cohort. Am J Gastroenterol. 2006;101(5):1012-23. PubMed PMID: 16696785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort. AU - Nguyen,Geoffrey C, AU - Torres,Esther A, AU - Regueiro,Miguel, AU - Bromfield,Gillian, AU - Bitton,Alain, AU - Stempak,Joanne, AU - Dassopoulos,Themistocles, AU - Schumm,Philip, AU - Gregory,Federico J, AU - Griffiths,Anne M, AU - Hanauer,Stephen B, AU - Hanson,Jennifer, AU - Harris,Mary L, AU - Kane,Sunanda V, AU - Orkwis,Heather Kiraly, AU - Lahaie,Raymond, AU - Oliva-Hemker,Maria, AU - Pare,Pierre, AU - Wild,Gary E, AU - Rioux,John D, AU - Yang,Huiying, AU - Duerr,Richard H, AU - Cho,Judy H, AU - Steinhart,A Hillary, AU - Brant,Steven R, AU - Silverberg,Mark S, PY - 2006/5/16/pubmed PY - 2006/6/7/medline PY - 2006/5/16/entrez SP - 1012 EP - 23 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 101 IS - 5 N2 - OBJECTIVES: Inflammatory bowel disease (IBD), comprising primarily of Crohn's disease (CD) and ulcerative colitis (UC), is increasingly prevalent in racial and ethnic minorities. This study was undertaken to characterize racial differences in disease phenotype in a predominantly adult population. METHODS: Phenotype data on 830 non-Hispanic white, 127 non-Hispanic African American, and 169 Hispanic IBD patients, recruited from six academic centers, were abstracted from medical records and compiled in the NIDDK-IBD Genetics Consortium repository. We characterized racial differences in family history, disease location and behavior, surgical history, and extraintestinal manifestations (EIMs) using standardized definitions. RESULTS: African American CD patients were more likely than whites to develop esophagogastroduodenal CD (OR = 2.8; 95% CI: 1.4-5.5), colorectal disease (OR = 1.9; 95% CI: 1.1-3.4), perianal disease (OR = 1.7; 95% CI: 1.03-2.8), but less likely to have ileal involvement (OR = 0.55; 95% CI: 0.32-0.96). They were also at higher risk for uveitis (OR = 5.5; 95% CI: 2.3-13.0) and sacroiliitis (OR = 4.0; 95% CI: 1.55-10.1). Hispanics had higher prevalence of perianal CD (OR = 2.9; 95% CI: 1.8-4.6) and erythema nodosum (3.3; 95% CI: 1.7-6.4). Among UC patients, Hispanics had more proximal disease extent. Both African American and Hispanic CD patients, but not UC patients, had lower prevalences of family history of IBD than their white counterparts. CONCLUSIONS: There are racial differences in IBD family history, disease location, and EIMs that may reflect underlying genetic variations and have important implications for diagnosis and management of disease. These findings underscore the need for further studies in minority populations. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/16696785/full_citation L2 - https://Insights.ovid.com/pubmed?pmid=16696785 DB - PRIME DP - Unbound Medicine ER -