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Trans, and n-3 polyunsaturated fatty acids and vascular function-a yin yang situation?

Abstract

Trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) have opposite effects on several biological functions. We report a study on the effects on risk markers for cardiovascular disease. Eighty-seven healthy males were randomly assigned to 8 weeks of daily intake of either 20 g of industrially produced TFA (IP-TFA), 4 g n-3 PUFA, or control fat, incorporated in bakery products as part of the daily food. High-density lipoprotein cholesterol decreased in the TFA-group, triglycerides and mean arterial blood pressure decreased in the n-3 group. Heart rate variability (HRV), arterial dilatory capacity, flow mediated vasodilation, compliance, and distensibility were unchanged. Post hoc, we did a subgroup analysis of the results from the subjects with normal initial HRV. In these, 24-h heart rate (HR) was significantly increased by approximately three beats/min in the TFA group, with a decrease of the same magnitude in the n-3 group. A high HR is associated to an increased mortality and vice versa. Our results thus support the notion that IP-TFA and n-3 PUFA affect risk for cardiovascular mortality via mechanisms not only related to changes in plasma concentrations of lipids and lipoproteins.

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  • Authors+Show Affiliations

    ,

    Capio Diagnostics Ltd., Copenhagen, Denmark. jdcon@post4.tele.dk

    , , ,

    Source

    Atherosclerosis. Supplements 7:2 2006 May pg 33-5

    MeSH

    Adult
    Blood Pressure
    Cardiovascular Diseases
    Dietary Fats, Unsaturated
    Double-Blind Method
    Fatty Acids, Omega-3
    Heart Rate
    Humans
    Lipoproteins, HDL
    Male
    Middle Aged
    Time Factors
    Trans Fatty Acids
    Triglycerides
    Vasodilation

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    16713391

    Citation

    Dyerberg, Jørn, et al. "Trans, and N-3 Polyunsaturated Fatty Acids and Vascular Function-a Yin Yang Situation?" Atherosclerosis. Supplements, vol. 7, no. 2, 2006, pp. 33-5.
    Dyerberg J, Christensen JH, Eskesen D, et al. Trans, and n-3 polyunsaturated fatty acids and vascular function-a yin yang situation? Atheroscler Suppl. 2006;7(2):33-5.
    Dyerberg, J., Christensen, J. H., Eskesen, D., Astrup, A., & Stender, S. (2006). Trans, and n-3 polyunsaturated fatty acids and vascular function-a yin yang situation? Atherosclerosis. Supplements, 7(2), pp. 33-5.
    Dyerberg J, et al. Trans, and N-3 Polyunsaturated Fatty Acids and Vascular Function-a Yin Yang Situation. Atheroscler Suppl. 2006;7(2):33-5. PubMed PMID: 16713391.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Trans, and n-3 polyunsaturated fatty acids and vascular function-a yin yang situation? AU - Dyerberg,Jørn, AU - Christensen,Jeppe H, AU - Eskesen,Dorte, AU - Astrup,Arne, AU - Stender,Steen, Y1 - 2006/05/18/ PY - 2006/5/23/pubmed PY - 2006/11/15/medline PY - 2006/5/23/entrez SP - 33 EP - 5 JF - Atherosclerosis. Supplements JO - Atheroscler Suppl VL - 7 IS - 2 N2 - Trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) have opposite effects on several biological functions. We report a study on the effects on risk markers for cardiovascular disease. Eighty-seven healthy males were randomly assigned to 8 weeks of daily intake of either 20 g of industrially produced TFA (IP-TFA), 4 g n-3 PUFA, or control fat, incorporated in bakery products as part of the daily food. High-density lipoprotein cholesterol decreased in the TFA-group, triglycerides and mean arterial blood pressure decreased in the n-3 group. Heart rate variability (HRV), arterial dilatory capacity, flow mediated vasodilation, compliance, and distensibility were unchanged. Post hoc, we did a subgroup analysis of the results from the subjects with normal initial HRV. In these, 24-h heart rate (HR) was significantly increased by approximately three beats/min in the TFA group, with a decrease of the same magnitude in the n-3 group. A high HR is associated to an increased mortality and vice versa. Our results thus support the notion that IP-TFA and n-3 PUFA affect risk for cardiovascular mortality via mechanisms not only related to changes in plasma concentrations of lipids and lipoproteins. SN - 1567-5688 UR - https://www.unboundmedicine.com/medline/citation/16713391/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5688(06)80101-7 DB - PRIME DP - Unbound Medicine ER -