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High-iron diet: foe or feat in ulcerative colitis and ulcerative colitis-associated carcinogenesis.

Abstract

Anemia associated with long-standing chronic inflammation and iron deficiency, and the increased risk for the development of dysplasia and carcinoma, are two of the most common complications in patients with ulcerative colitis (UC). Because of iron and nutrition deficiency, UC patients are encouraged to consume a high-protein and high-iron diet. The crucial clinical question is the effect of a high-iron diet on inflammation activity and inflammation-driven carcinogenesis. Is a high-iron diet a foe or a feat in UC and UC-associated carcinogenesis? This review updates the progress and information on (1) iron nutrition and iron-deficiency anemia in patients with UC, (2) experimental evidence of the exacerbating effect of a high-iron diet on UC and its associated carcinogenesis and the difference between a high-iron diet and parental iron supplementation, (3) the clinical efficacy of, and concerns about, oral and intravenous iron supplements in patients with inflammatory bowel disease and iron deficiency anemia, and (4) the clinical implications of long-term iron supplements and management of UC. These experimental findings from animal models provide evidence to warrant further consideration and clinical studies of iron nutrition, inflammation activity, and cancer development.

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  • Authors+Show Affiliations

    ,

    Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, USA.

    , ,

    Source

    MeSH

    Administration, Oral
    Anemia, Iron-Deficiency
    Animals
    Biological Availability
    Cell Transformation, Neoplastic
    Colitis, Ulcerative
    Colorectal Neoplasms
    Dietary Supplements
    Disease Models, Animal
    Disease Progression
    Dose-Response Relationship, Drug
    Humans
    Iron, Dietary
    Oxidative Stress

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    16721219

    Citation

    Seril, Darren N., et al. "High-iron Diet: Foe or Feat in Ulcerative Colitis and Ulcerative Colitis-associated Carcinogenesis." Journal of Clinical Gastroenterology, vol. 40, no. 5, 2006, pp. 391-7.
    Seril DN, Liao J, West AB, et al. High-iron diet: foe or feat in ulcerative colitis and ulcerative colitis-associated carcinogenesis. J Clin Gastroenterol. 2006;40(5):391-7.
    Seril, D. N., Liao, J., West, A. B., & Yang, G. Y. (2006). High-iron diet: foe or feat in ulcerative colitis and ulcerative colitis-associated carcinogenesis. Journal of Clinical Gastroenterology, 40(5), pp. 391-7.
    Seril DN, et al. High-iron Diet: Foe or Feat in Ulcerative Colitis and Ulcerative Colitis-associated Carcinogenesis. J Clin Gastroenterol. 2006;40(5):391-7. PubMed PMID: 16721219.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High-iron diet: foe or feat in ulcerative colitis and ulcerative colitis-associated carcinogenesis. AU - Seril,Darren N, AU - Liao,Jie, AU - West,Alexander Brian, AU - Yang,Guang-Yu, PY - 2006/5/25/pubmed PY - 2006/10/27/medline PY - 2006/5/25/entrez SP - 391 EP - 7 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 40 IS - 5 N2 - Anemia associated with long-standing chronic inflammation and iron deficiency, and the increased risk for the development of dysplasia and carcinoma, are two of the most common complications in patients with ulcerative colitis (UC). Because of iron and nutrition deficiency, UC patients are encouraged to consume a high-protein and high-iron diet. The crucial clinical question is the effect of a high-iron diet on inflammation activity and inflammation-driven carcinogenesis. Is a high-iron diet a foe or a feat in UC and UC-associated carcinogenesis? This review updates the progress and information on (1) iron nutrition and iron-deficiency anemia in patients with UC, (2) experimental evidence of the exacerbating effect of a high-iron diet on UC and its associated carcinogenesis and the difference between a high-iron diet and parental iron supplementation, (3) the clinical efficacy of, and concerns about, oral and intravenous iron supplements in patients with inflammatory bowel disease and iron deficiency anemia, and (4) the clinical implications of long-term iron supplements and management of UC. These experimental findings from animal models provide evidence to warrant further consideration and clinical studies of iron nutrition, inflammation activity, and cancer development. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/16721219/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=16721219 DB - PRIME DP - Unbound Medicine ER -