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The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease.

Abstract

PURPOSE OF REVIEW

The tragic circumstances of the Dutch Hunger Winter of 1944-1945 created a unique opportunity to study the relation between exposure to prenatal famine and health in adult life. This review addresses the literature on the effects of maternal malnutrition during the different periods of gestation and childhood on health in adult life.

RECENT FINDINGS

Exposure to famine during gestation resulted in increases in impaired glucose tolerance, obesity, coronary heart disease, atherogenic lipid profile, hypertension, microalbuminuria, schizophrenia, antisocial personality and affective disorders. Exposure to famine during childhood resulted in changes in reproductive function, earlier menopause, changes in insulin-like growth factor-I and increases in breast cancer.

SUMMARY

Exposure to famine during gestation and childhood has life-long effects on health, and these effects vary depending on the timing of exposure as well as evolution of the recovery period.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland.

    Source

    MeSH

    Breast Neoplasms
    Coronary Disease
    Female
    Glucose Intolerance
    Humans
    Maternal Nutritional Physiological Phenomena
    Models, Biological
    Obesity
    Pregnancy
    Prenatal Exposure Delayed Effects
    Starvation
    Time Factors
    Wasting Disease, Chronic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    16778567

    Citation

    Kyle, Ursula G., and Claude Pichard. "The Dutch Famine of 1944-1945: a Pathophysiological Model of Long-term Consequences of Wasting Disease." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 9, no. 4, 2006, pp. 388-94.
    Kyle UG, Pichard C. The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Curr Opin Clin Nutr Metab Care. 2006;9(4):388-94.
    Kyle, U. G., & Pichard, C. (2006). The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Current Opinion in Clinical Nutrition and Metabolic Care, 9(4), pp. 388-94.
    Kyle UG, Pichard C. The Dutch Famine of 1944-1945: a Pathophysiological Model of Long-term Consequences of Wasting Disease. Curr Opin Clin Nutr Metab Care. 2006;9(4):388-94. PubMed PMID: 16778567.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. AU - Kyle,Ursula G, AU - Pichard,Claude, PY - 2006/6/17/pubmed PY - 2006/12/9/medline PY - 2006/6/17/entrez SP - 388 EP - 94 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 9 IS - 4 N2 - PURPOSE OF REVIEW: The tragic circumstances of the Dutch Hunger Winter of 1944-1945 created a unique opportunity to study the relation between exposure to prenatal famine and health in adult life. This review addresses the literature on the effects of maternal malnutrition during the different periods of gestation and childhood on health in adult life. RECENT FINDINGS: Exposure to famine during gestation resulted in increases in impaired glucose tolerance, obesity, coronary heart disease, atherogenic lipid profile, hypertension, microalbuminuria, schizophrenia, antisocial personality and affective disorders. Exposure to famine during childhood resulted in changes in reproductive function, earlier menopause, changes in insulin-like growth factor-I and increases in breast cancer. SUMMARY: Exposure to famine during gestation and childhood has life-long effects on health, and these effects vary depending on the timing of exposure as well as evolution of the recovery period. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/16778567/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=16778567 DB - PRIME DP - Unbound Medicine ER -