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The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease.
Curr Opin Clin Nutr Metab Care 2006; 9(4):388-94CO

Abstract

PURPOSE OF REVIEW

The tragic circumstances of the Dutch Hunger Winter of 1944-1945 created a unique opportunity to study the relation between exposure to prenatal famine and health in adult life. This review addresses the literature on the effects of maternal malnutrition during the different periods of gestation and childhood on health in adult life.

RECENT FINDINGS

Exposure to famine during gestation resulted in increases in impaired glucose tolerance, obesity, coronary heart disease, atherogenic lipid profile, hypertension, microalbuminuria, schizophrenia, antisocial personality and affective disorders. Exposure to famine during childhood resulted in changes in reproductive function, earlier menopause, changes in insulin-like growth factor-I and increases in breast cancer.

SUMMARY

Exposure to famine during gestation and childhood has life-long effects on health, and these effects vary depending on the timing of exposure as well as evolution of the recovery period.

Authors+Show Affiliations

Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16778567

Citation

Kyle, Ursula G., and Claude Pichard. "The Dutch Famine of 1944-1945: a Pathophysiological Model of Long-term Consequences of Wasting Disease." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 9, no. 4, 2006, pp. 388-94.
Kyle UG, Pichard C. The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Curr Opin Clin Nutr Metab Care. 2006;9(4):388-94.
Kyle, U. G., & Pichard, C. (2006). The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Current Opinion in Clinical Nutrition and Metabolic Care, 9(4), pp. 388-94.
Kyle UG, Pichard C. The Dutch Famine of 1944-1945: a Pathophysiological Model of Long-term Consequences of Wasting Disease. Curr Opin Clin Nutr Metab Care. 2006;9(4):388-94. PubMed PMID: 16778567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. AU - Kyle,Ursula G, AU - Pichard,Claude, PY - 2006/6/17/pubmed PY - 2006/12/9/medline PY - 2006/6/17/entrez SP - 388 EP - 94 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 9 IS - 4 N2 - PURPOSE OF REVIEW: The tragic circumstances of the Dutch Hunger Winter of 1944-1945 created a unique opportunity to study the relation between exposure to prenatal famine and health in adult life. This review addresses the literature on the effects of maternal malnutrition during the different periods of gestation and childhood on health in adult life. RECENT FINDINGS: Exposure to famine during gestation resulted in increases in impaired glucose tolerance, obesity, coronary heart disease, atherogenic lipid profile, hypertension, microalbuminuria, schizophrenia, antisocial personality and affective disorders. Exposure to famine during childhood resulted in changes in reproductive function, earlier menopause, changes in insulin-like growth factor-I and increases in breast cancer. SUMMARY: Exposure to famine during gestation and childhood has life-long effects on health, and these effects vary depending on the timing of exposure as well as evolution of the recovery period. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/16778567/full_citation L2 - http://dx.doi.org/10.1097/01.mco.0000232898.74415.42 DB - PRIME DP - Unbound Medicine ER -