Tags

Type your tag names separated by a space and hit enter

Pesticide exposure and risk for Parkinson's disease.
Ann Neurol. 2006 Aug; 60(2):197-203.AN

Abstract

OBJECTIVE

Chronic, low-dose exposure to pesticides is suspected to increase the risk for Parkinson's disease (PD), but data are inconclusive.

METHODS

We prospectively examined whether individuals exposed to pesticides have higher risk for PD than those not exposed. The study population comprised participants in the Cancer Prevention Study II Nutrition Cohort, a longitudinal investigation of US men and women initiated in 1992 by the American Cancer Society. Follow-up surveys were conducted in 1997, 1999, and 2001. The 143,325 individuals who returned the 2001 survey and did not have a diagnosis or symptoms of PD at baseline (1992) were included in the analyses.

RESULTS

Exposure to pesticides was reported by 7,864 participants (5.7%), including 1,956 farmers, ranchers, or fishermen. Individuals exposed to pesticides had a 70% higher incidence of PD than those not exposed (adjusted relative risk, 1.7; 95% confidence interval, 1.2-2.3; p = 0.002). The relative risk for pesticide exposure was similar in farmers and nonfarmers. No relation was found between risk for PD and exposure to asbestos, chemical/acids/solvents, coal or stone dust, or eight other occupational exposures.

INTERPRETATION

These data support the hypothesis that exposure to pesticides may increase risk for PD. Future studies should seek to identify the specific chemicals responsible for this association.

Authors+Show Affiliations

Ascherio A
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. aascheri@hsph.harvard.edu
Chen H
No affiliation info available
Weisskopf MG
No affiliation info available
O'Reilly E
No affiliation info available
McCullough ML
No affiliation info available
Calle EE
No affiliation info available
Schwarzschild MA
No affiliation info available
Thun MJ
No affiliation info available

MeSH

AgedAged, 80 and overCohort StudiesDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedNutritional Physiological PhenomenaParkinson Disease, SecondaryPesticidesRiskUnited States

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16802290

Citation

Ascherio, Alberto, et al. "Pesticide Exposure and Risk for Parkinson's Disease." Annals of Neurology, vol. 60, no. 2, 2006, pp. 197-203.
Ascherio A, Chen H, Weisskopf MG, et al. Pesticide exposure and risk for Parkinson's disease. Ann Neurol. 2006;60(2):197-203.
Ascherio, A., Chen, H., Weisskopf, M. G., O'Reilly, E., McCullough, M. L., Calle, E. E., Schwarzschild, M. A., & Thun, M. J. (2006). Pesticide exposure and risk for Parkinson's disease. Annals of Neurology, 60(2), 197-203.
Ascherio A, et al. Pesticide Exposure and Risk for Parkinson's Disease. Ann Neurol. 2006;60(2):197-203. PubMed PMID: 16802290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pesticide exposure and risk for Parkinson's disease. AU - Ascherio,Alberto, AU - Chen,Honglei, AU - Weisskopf,Marc G, AU - O'Reilly,Eilis, AU - McCullough,Marjorie L, AU - Calle,Eugenia E, AU - Schwarzschild,Michael A, AU - Thun,Michael J, PY - 2006/6/28/pubmed PY - 2006/9/16/medline PY - 2006/6/28/entrez SP - 197 EP - 203 JF - Annals of neurology JO - Ann Neurol VL - 60 IS - 2 N2 - OBJECTIVE: Chronic, low-dose exposure to pesticides is suspected to increase the risk for Parkinson's disease (PD), but data are inconclusive. METHODS: We prospectively examined whether individuals exposed to pesticides have higher risk for PD than those not exposed. The study population comprised participants in the Cancer Prevention Study II Nutrition Cohort, a longitudinal investigation of US men and women initiated in 1992 by the American Cancer Society. Follow-up surveys were conducted in 1997, 1999, and 2001. The 143,325 individuals who returned the 2001 survey and did not have a diagnosis or symptoms of PD at baseline (1992) were included in the analyses. RESULTS: Exposure to pesticides was reported by 7,864 participants (5.7%), including 1,956 farmers, ranchers, or fishermen. Individuals exposed to pesticides had a 70% higher incidence of PD than those not exposed (adjusted relative risk, 1.7; 95% confidence interval, 1.2-2.3; p = 0.002). The relative risk for pesticide exposure was similar in farmers and nonfarmers. No relation was found between risk for PD and exposure to asbestos, chemical/acids/solvents, coal or stone dust, or eight other occupational exposures. INTERPRETATION: These data support the hypothesis that exposure to pesticides may increase risk for PD. Future studies should seek to identify the specific chemicals responsible for this association. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16802290/full_citation L2 - https://doi.org/10.1002/ana.20904 DB - PRIME DP - Unbound Medicine ER -