TY - JOUR T1 - Two cases of fatal amlodipine overdose. AU - Sklerov,Jason H, AU - Levine,Barry, AU - Ingwersen,Kathleen M, AU - Aronica-Pollack,Patricia A, AU - Fowler,David, PY - 2006/7/15/pubmed PY - 2006/12/9/medline PY - 2006/7/15/entrez SP - 346 EP - 51 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 30 IS - 5 N2 - Two fatal overdoses of the calcium channel blocker amlodipine are described. Postmortem samples were screened for volatiles and therapeutic and abused drugs. Amlodipine was measured by liquid chromatography-atmospheric pressure photoionization-mass spectrometry. The heart blood amlodipine concentrations for the two cases were 2.4 and 0.95 mg/L, and amlodipine was quantified in all other tissues. In the first case, venlafaxine and norvenlafaxine were also found, and the angiotensin receptor antagonist olmesartan was tentatively identified. The concentrations of amlodipine are compared with previously reported fatal and nonfatal overdoses. The medical examiners ruled in both cases that the manner of death was suicide and the causes of death were mixed drug intoxication and amlodipine intoxication. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/16839474/Two_cases_of_fatal_amlodipine_overdose_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/30.5.346 DB - PRIME DP - Unbound Medicine ER -