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Chlamydia pneumoniae infection and the risk of multiple sclerosis: a meta-analysis.

Abstract

We conducted a meta-analysis of studies comparing the presence of Chlamydia pneumoniae (Cpn) between multiple sclerosis (MS) patients and other neurological diseases patients or healthy controls. We identified 26 studies with 1332 MS patients and 1464 controls. Using random-effects methods, MS patients were found more likely to have detectable levels of Cpn DNA (OR = 3.216; 95% CI: 1.204, 8.585) in their cerebrospinal fluid, and intrathecally synthesized immunoglobulins (OR = 3.842; 95% CI: 1.317, 11.212), compared to other patients with neurological diseases. There is no evidence for increased levels of serum immunoglobulins (OR = 1.068; 95% CI: 0.745, 1.530), even though this result is confounded by the presence of studies using normal subjects as controls. Similarly, there is no evidence for association of immunoglobulins against Cpn in the cerebrospinal fluid (OR = 3.815; 95% CI: 0.715, 20.369). Up to 59.7% of the between-studies variability could be explained by the inappropriate matching of cases and controls for gender. In random-effects meta-regressions, adjusting for the confounding effect of gender differences results in stronger and statistically significant associations of MS with detectable levels of Cpn DNA, intrathecally synthesized immunoglobulins and immunoglobulins in the cerebrospinal fluid. Even though the presence of Cpn is clearly more likely in MS patients, these findings are insufficient to establish an etiologic relation.

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  • Authors+Show Affiliations

    ,

    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, 15701, Greece. pbagos@biol.uoa.gr

    ,

    Source

    MeSH

    Antibodies, Bacterial
    Chlamydophila Infections
    Chlamydophila pneumoniae
    Humans
    Multiple Sclerosis
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    16900753

    Citation

    Bagos, P G., et al. "Chlamydia Pneumoniae Infection and the Risk of Multiple Sclerosis: a Meta-analysis." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 12, no. 4, 2006, pp. 397-411.
    Bagos PG, Nikolopoulos G, Ioannidis A. Chlamydia pneumoniae infection and the risk of multiple sclerosis: a meta-analysis. Mult Scler. 2006;12(4):397-411.
    Bagos, P. G., Nikolopoulos, G., & Ioannidis, A. (2006). Chlamydia pneumoniae infection and the risk of multiple sclerosis: a meta-analysis. Multiple Sclerosis (Houndmills, Basingstoke, England), 12(4), pp. 397-411.
    Bagos PG, Nikolopoulos G, Ioannidis A. Chlamydia Pneumoniae Infection and the Risk of Multiple Sclerosis: a Meta-analysis. Mult Scler. 2006;12(4):397-411. PubMed PMID: 16900753.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Chlamydia pneumoniae infection and the risk of multiple sclerosis: a meta-analysis. AU - Bagos,P G, AU - Nikolopoulos,G, AU - Ioannidis,A, PY - 2006/8/12/pubmed PY - 2006/9/22/medline PY - 2006/8/12/entrez SP - 397 EP - 411 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 12 IS - 4 N2 - We conducted a meta-analysis of studies comparing the presence of Chlamydia pneumoniae (Cpn) between multiple sclerosis (MS) patients and other neurological diseases patients or healthy controls. We identified 26 studies with 1332 MS patients and 1464 controls. Using random-effects methods, MS patients were found more likely to have detectable levels of Cpn DNA (OR = 3.216; 95% CI: 1.204, 8.585) in their cerebrospinal fluid, and intrathecally synthesized immunoglobulins (OR = 3.842; 95% CI: 1.317, 11.212), compared to other patients with neurological diseases. There is no evidence for increased levels of serum immunoglobulins (OR = 1.068; 95% CI: 0.745, 1.530), even though this result is confounded by the presence of studies using normal subjects as controls. Similarly, there is no evidence for association of immunoglobulins against Cpn in the cerebrospinal fluid (OR = 3.815; 95% CI: 0.715, 20.369). Up to 59.7% of the between-studies variability could be explained by the inappropriate matching of cases and controls for gender. In random-effects meta-regressions, adjusting for the confounding effect of gender differences results in stronger and statistically significant associations of MS with detectable levels of Cpn DNA, intrathecally synthesized immunoglobulins and immunoglobulins in the cerebrospinal fluid. Even though the presence of Cpn is clearly more likely in MS patients, these findings are insufficient to establish an etiologic relation. SN - 1352-4585 UR - https://www.unboundmedicine.com/medline/citation/16900753/full_citation L2 - http://journals.sagepub.com/doi/full/10.1191/1352458506ms1291oa?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -