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Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Abstract

Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.

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  • Authors+Show Affiliations

    ,

    Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany. s.rohrmann@dkfz.de

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    American journal of epidemiology 164:11 2006 Dec 01 pg 1103-14

    MeSH

    Adult
    Alcohol Drinking
    Europe
    Female
    Follow-Up Studies
    Humans
    Incidence
    Lung Neoplasms
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16987924

    Citation

    Rohrmann, Sabine, et al. "Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." American Journal of Epidemiology, vol. 164, no. 11, 2006, pp. 1103-14.
    Rohrmann S, Linseisen J, Boshuizen HC, et al. Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Epidemiol. 2006;164(11):1103-14.
    Rohrmann, S., Linseisen, J., Boshuizen, H. C., Whittaker, J., Agudo, A., Vineis, P., ... Riboli, E. (2006). Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). American Journal of Epidemiology, 164(11), pp. 1103-14.
    Rohrmann S, et al. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Am J Epidemiol. 2006 Dec 1;164(11):1103-14. PubMed PMID: 16987924.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Rohrmann,Sabine, AU - Linseisen,Jakob, AU - Boshuizen,Hendriek C, AU - Whittaker,John, AU - Agudo,Antonio, AU - Vineis,Paolo, AU - Boffetta,Paolo, AU - Jensen,Majken K, AU - Olsen,Anja, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Françoise, AU - Bergmann,Manuela M, AU - Boeing,Heiner, AU - Allen,Naomi, AU - Key,Tim, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Kyriazi,Georgia, AU - Soukara,Stavroula, AU - Trichopoulou,Antonia, AU - Panico,Salvatore, AU - Palli,Domenico, AU - Sieri,Sabina, AU - Tumino,Rosario, AU - Peeters,Petra H M, AU - Bueno-de-Mesquita,H Bas, AU - Büchner,Frederike L, AU - Gram,Inger Torhild, AU - Lund,Eiliv, AU - Ardanaz,Eva, AU - Chirlaque,María-Dolores, AU - Dorronsoro,Miren, AU - Pérez,Maria-José Sánchez, AU - Quirós,Jose R, AU - Berglund,Göran, AU - Janzon,Lars, AU - Rasmuson,Torgny, AU - Weinehall,Lars, AU - Ferrari,Pietro, AU - Jenab,Mazda, AU - Norat,Teresa, AU - Riboli,Elio, Y1 - 2006/09/20/ PY - 2006/9/22/pubmed PY - 2007/1/31/medline PY - 2006/9/22/entrez SP - 1103 EP - 14 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 164 IS - 11 N2 - Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16987924/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj326 DB - PRIME DP - Unbound Medicine ER -