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Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Am J Epidemiol 2006; 164(11):1103-14AJ

Abstract

Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.

Authors+Show Affiliations

Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany. s.rohrmann@dkfz.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16987924

Citation

Rohrmann, Sabine, et al. "Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." American Journal of Epidemiology, vol. 164, no. 11, 2006, pp. 1103-14.
Rohrmann S, Linseisen J, Boshuizen HC, et al. Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Epidemiol. 2006;164(11):1103-14.
Rohrmann, S., Linseisen, J., Boshuizen, H. C., Whittaker, J., Agudo, A., Vineis, P., ... Riboli, E. (2006). Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). American Journal of Epidemiology, 164(11), pp. 1103-14.
Rohrmann S, et al. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Am J Epidemiol. 2006 Dec 1;164(11):1103-14. PubMed PMID: 16987924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Rohrmann,Sabine, AU - Linseisen,Jakob, AU - Boshuizen,Hendriek C, AU - Whittaker,John, AU - Agudo,Antonio, AU - Vineis,Paolo, AU - Boffetta,Paolo, AU - Jensen,Majken K, AU - Olsen,Anja, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Françoise, AU - Bergmann,Manuela M, AU - Boeing,Heiner, AU - Allen,Naomi, AU - Key,Tim, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Kyriazi,Georgia, AU - Soukara,Stavroula, AU - Trichopoulou,Antonia, AU - Panico,Salvatore, AU - Palli,Domenico, AU - Sieri,Sabina, AU - Tumino,Rosario, AU - Peeters,Petra H M, AU - Bueno-de-Mesquita,H Bas, AU - Büchner,Frederike L, AU - Gram,Inger Torhild, AU - Lund,Eiliv, AU - Ardanaz,Eva, AU - Chirlaque,María-Dolores, AU - Dorronsoro,Miren, AU - Pérez,Maria-José Sánchez, AU - Quirós,Jose R, AU - Berglund,Göran, AU - Janzon,Lars, AU - Rasmuson,Torgny, AU - Weinehall,Lars, AU - Ferrari,Pietro, AU - Jenab,Mazda, AU - Norat,Teresa, AU - Riboli,Elio, Y1 - 2006/09/20/ PY - 2006/9/22/pubmed PY - 2007/1/31/medline PY - 2006/9/22/entrez SP - 1103 EP - 14 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 164 IS - 11 N2 - Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16987924/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj326 DB - PRIME DP - Unbound Medicine ER -